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Generic Name: tretinoin (Oral route)


Oral route(Capsule, Liquid Filled)

Patients with acute promyelocytic leukemia (APL) can have severe adverse reactions to tretinoin including retinoic acid-APL (RA-APL) syndrome characterized by fever, dyspnea, acute respiratory distress, weight gain, radiographic pulmonary infiltrates, pleural and pericardial effusions, edema, and hepatic, renal, and multi-organ failure. High-dose steroids given at the first suspicion of the RA-APL syndrome appear to reduce morbidity and mortality. Patients can also develop rapidly evolving leukocytosis during therapy which can lead to an increased risk of life-threatening complications. There is a high risk that a severely deformed infant will result if tretinoin is administered during pregnancy. Pregnancy testing is necessary prior to initiation of treatment in women of childbearing potential and the patient must be instructed in the need to use two reliable forms of contraception simultaneously during therapy and for 1 month following discontinuation of therapy. Pregnancy testing and contraception counseling should be repeated monthly throughout the period of tretinoin treatment .

Commonly used brand name(s)

In the U.S.


Available Dosage Forms:

Capsule, Liquid Filled

Therapeutic Class: Antineoplastic Agent

Chemical Class: Retinoid

Uses For Vesanoid

Tretinoin belongs to the group of medicines known as retinoids (RET-i-noyds). It is used to treat a form of leukemia (acute promyelocytic leukemia [APL]).

Tretinoin has side effects that can be very serious. Be sure that you discuss with your doctor the good that this medicine can do as well as the risks of taking it.

This medicine is available only with your doctor's prescription.

Before Using Vesanoid

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Studies in a limited number of children between 1 and 16 years of age have shown that children may be especially sensitive to the effects of this medicine, and may be more likely than adults to experience severe headaches and some other side effects during treatment.


Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of tretinoin in the elderly with use in other age groups.

Pregnancy Pregnancy Category Explanation All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aminocaproic Acid Aprotinin Paclitaxel Paclitaxel Protein-Bound Tetracycline Tranexamic Acid

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Fluconazole Ketoconazole Voriconazole Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of Vesanoid

It is very important that you take tretinoin only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (capsules): For acute promyelocytic leukemia (APL): Adults—Dose is based on body size and must be determined by your doctor. The usual dose is 45 milligrams (mg) for each square meter of body surface area a day, given in two equally divided doses. Children—The dose will be determined by your doctor. Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If it is almost time for your next dose, check with your health care professional to find out how much medicine to take for the next dose.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Vesanoid

Your doctor should check your progress at regular visits to make sure that the medicine is working properly and to check for unwanted effects.

Tretinoin causes fever, headache, tiredness, and weakness in most people who take it. It is very important that you continue taking the medicine even if it makes you feel ill. Your health care professional may be able to suggest ways to relieve some of these effects. However, if you develop a very severe headache or a headache that occurs together with nausea, vomiting, or vision problems, check with your doctor right away.

Tretinoin sometimes causes a severe reaction that affects the lungs at first, but can later spread to other parts of the body. Signs of this reaction include breathing problems, bone pain, chest pain, and fever. Check with your doctor right away if any of these effects occur during treatment .

Vesanoid Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common Black, tarry stools bleeding blistering bloody stools bone pain burning coldness difficulty in moving discomfort or pain in chest enlarged heart feeling of pressure fever hives infection inflammation joint pain lumps numbness paleness of skin rash redness scaring seizures shortness of breath, troubled breathing, tightness in chest, or wheezing soreness stinging sweating increased swelling swollen joints tenderness tingling ulceration unusual tiredness or weakness vomiting of blood or material that looks like coffee grounds warmness at site weight gain (occurring together with any of the other symptoms listed before) Less common Blue lips and fingernails convulsions (seizures) difficulty in speaking, slow speech, or inability to speak faintness feeling of heaviness in chest headache (severe) inability to move arms, legs, or muscles of the face nausea and vomiting (occurring together with a headache) no blood pressure or pulse pain in back or left arm painful, red lumps under the skin, mostly on the legs prominent superficial veins over affected area stopping of heart unconsciousness vision problems (occurring together with a headache) warmth

Check with your doctor as soon as possible if any of the following side effects occur:

More common Any change in vision (not occurring with a headache) coughing, sneezing, sore throat, and stuffy or runny nose cracked lips crusting, redness, pain, or sores in mouth or nose decreased urination earache or feeling of fullness in the ear increase or decrease in blood pressure irregular heartbeat mental depression pain in stomach, side, abdomen or back pain and swelling in leg or foot skin rash swelling of abdomen (stomach area) swelling of face, fingers, hands, feet, or lower legs Less common Bone swelling cramping or pain in stomach (severe) difficult or painful urination drowsiness (very severe and continuing) hallucinations (seeing, hearing, or feeling things that are not there) hearing loss heartburn, indigestion, or nausea (severe and continuing) mood, mental, or personality changes pain in lower back or side swollen area that feels sore and tender yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Acid or sour stomach agitation anxiety belching blurred vision bloating burning, crawling, or tingling feeling in the skin chills confusion constipation darkened urine diarrhea dizziness dryness of skin, mouth, or nose fast heartbeat flushing general feeling of discomfort or illness hair loss headache (mild and not occurring together with other side effects) indigestion irritability itching of skin loss of appetite mood or mental changes muscle pain nausea and vomiting (not occurring together with a headache) shivering trouble sleeping weakness weight loss Less common Anxiety and restlessness (occurring together) clumsiness or unsteadiness when walking difficulty sleeping disorientation forgetfulness frequent urination lethargy lightheadedness low body temperature redness, soreness or itching skin sores, welting or blisters sores on genitals swelling of feet or lower legs thirst trembling, sometimes with a flapping movement weak or feeble pulse weakness in legs

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Vesanoid side effects (in more detail)

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More Vesanoid resources Vesanoid Side Effects (in more detail)Vesanoid Use in Pregnancy & BreastfeedingDrug ImagesVesanoid Drug InteractionsVesanoid Support Group1 Review for Vesanoid - Add your own review/rating Vesanoid Prescribing Information (FDA) Vesanoid MedFacts Consumer Leaflet (Wolters Kluwer) Vesanoid Concise Consumer Information (Cerner Multum) Vesanoid Monograph (AHFS DI) Tretinoin Prescribing Information (FDA) Compare Vesanoid with other medications Acute Promyelocytic Leukemia


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