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Pronunciation: feb-UX-oh-stat
Generic Name: Febuxostat
Brand Name: Uloric
Uloric is used for:

Long-term treatment of high blood uric acid levels in patients with gout.

Uloric is a xanthine oxidase inhibitor. It works by blocking an enzyme in the body (xanthine oxidase), which lowers levels of uric acid in the blood. This helps to prevent gout flare-ups.

Do NOT use Uloric if: you are allergic to any ingredient in Uloric you do not have symptoms caused by high blood uric acid levels you have high blood uric acid levels caused by a condition other than gout (eg, Lesch-Nyhan syndrome, cancer or treatment of cancer, organ transplant) you are taking azathioprine or mercaptopurine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Uloric:

Some medical conditions may interact with Uloric. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have liver or kidney problems if you have a history of heart problems (eg, a heart attack) or a stroke

Some MEDICINES MAY INTERACT with Uloric. Tell your health care provider if you are taking any other medicines, especially any of the following

Azathioprine, mercaptopurine, and theophylline because the risk of their side effects may be increased by Uloric

This may not be a complete list of all interactions that may occur. Ask your health care provider if Uloric may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Uloric:

Use Uloric as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Uloric. Talk to your pharmacist if you have questions about this information. Take Uloric by mouth with or without food. Continue to take Uloric even if you feel well. Do not miss any doses. If you miss a dose of Uloric, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Uloric.

Important safety information: Some patients may experience a gout flare-up when they start taking Uloric. Your doctor may prescribe a nonsteroidal anti-inflammatory drug (NSAID) or colchicine to take to help control or prevent a gout flare-up. If you experience a gout flare-up, do not stop taking this medication without talking to your doctor. Talk with your doctor if you have any questions or concerns. Lab tests, including uric acid levels and liver function, may be performed while you take Uloric. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Uloric should be used with extreme caution in CHILDREN younger than 18 years; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Uloric while you are pregnant. It is not known if Uloric is found in breast milk. If you are or will be breast-feeding while you take Uloric, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Uloric:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Joint pain; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain or discomfort; confusion; dark urine; decrease in the amount of urine produced; fainting; fast, slow, or irregular heartbeat; fever or chills; mental or mood changes; numbness of an arm or leg; one-sided weakness; pale stools; red, swollen, blistered, or peeling skin; severe muscle pain; shortness of breath; signs of high or low blood pressure (eg, headache, dizziness, tiredness, weakness); slurred speech; stomach pain; unusual bruising or bleeding; vision problems (eg, blurred vision); yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

See also: Uloric side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Uloric:

Store Uloric at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Uloric out of the reach of children and away from pets.

General information: If you have any questions about Uloric, please talk with your doctor, pharmacist, or other health care provider. Uloric is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Uloric. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition Copyright © 2012 Wolters Kluwer Health, Inc. More Uloric resources Uloric Side Effects (in more detail) Uloric Use in Pregnancy & Breastfeeding Uloric Drug Interactions Uloric Support Group 6 Reviews for Uloric - Add your own review/rating Uloric Prescribing Information (FDA) Uloric Consumer Overview Uloric Monograph (AHFS DI) Uloric Advanced Consumer (Micromedex) - Includes Dosage Information Febuxostat Professional Patient Advice (Wolters Kluwer) Compare Uloric with other medications Gout


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