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Generic Name: hylan G-F 20 (HI lan G F 20)
Brand Names: Synvisc, Synvisc-One

What is hylan G-F 20?

Hylan G-F 20 is similar to the fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints.

Hylan G-F 20 is used to treat knee pain caused by osteoarthritis.

Hylan G-F 20 is usually given after other arthritis medications have been tried without successful treatment of symptoms.

Hylan G-F 20 may also be used for purposes not listed in this medication guide.

What is the most important information I should know about hylan G-F 20? You should not receive hylan G-F 20 if you are allergic to it, or if you have an infection in your knee or in the skin around your knee.

Before you receive a hylan G-F 20 injection, tell your doctor if you have blood clots or circulation problems in your legs, or an allergy to birds, feathers, or egg products.

For at least 48 hours after your injection, avoid jogging, strenuous activity, high-impact sports, or standing for longer than 1 hour at a time.

Call your doctor at once if you have severe pain or swelling around the knee after the injection. What should I discuss with my health care provider before receiving hylan G-F 20? You should not receive hylan G-F 20 if you are allergic to it, or if you have an infection in your knee or in the skin around your knee.

To make sure you can safely receive hylan G-F 20, tell your doctor if you have:

blood clots or circulation problems in your legs; or

an allergy to birds, feathers, or egg products.

It is not known whether hylan G-F 20 will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether hylan G-F 20 passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Hylan G-F 20 is generally not used in anyone younger than 21 years old. How is hylan G-F 20 given?

Hylan G-F 20 is injected directly into your knee joint. A healthcare provider will give you this injection.

Hylan G-F 20 is usually given once every week for 3 weeks. Follow your doctor's dosing instructions very carefully.

To prevent pain and swelling, your doctor may recommend resting your knee or applying ice for a short time after your injection.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your hylan G-F 20 injection.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving hylan G-F 20?

For at least 48 hours after your injection, avoid jogging, strenuous activity, or high-impact sports such as soccer or tennis. Also avoid weight-bearing activity or standing for longer than 1 hour at a time. Ask your doctor how long to wait before you resume these activities.

Hylan G-F 20 side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have severe pain or swelling around the knee after the injection.

Less serious side effects may include:

warmth, pain, stiffness, swelling, or puffiness where the medicine was injected;

muscle pain, trouble walking;

fever, chills, nausea;

numbness or tingly feeling;

headache, dizziness;

tired feeling; or

itching or skin irritation around the knee.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect hylan G-F 20?

There may be other drugs that can interact with hylan G-F 20. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Synvisc resources Synvisc Side Effects (in more detail)Synvisc Use in Pregnancy & BreastfeedingSynvisc Drug InteractionsSynvisc Support Group6 Reviews for Synvisc - Add your own review/rating Synvisc Advanced Consumer (Micromedex) - Includes Dosage Information Synvisc Solution MedFacts Consumer Leaflet (Wolters Kluwer) Synvisc Consumer Overview Hylan G-F 20 Compare Synvisc with other medications Osteoarthritis Where can I get more information? Your doctor can provide more information about hylan G-F 20.

See also: Synvisc side effects (in more detail)

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