Protelos

PROTELOS 2g

granules for oral suspension

Strontium ranelate

Read all of this leaflet carefully before you start taking this medicine. Keep this leaflet. You may need to read it again. If you have any further questions, ask your doctor or your pharmacist. This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or your pharmacist. In this leaflet: 1. What PROTELOS is and what it is used for 2. Before you take PROTELOS 3. How to take PROTELOS 4. Possible side effects 5. How to store PROTELOS 6. Further information What Protelos Is And What It Is Used For

PROTELOS is a non-hormonal medicine used to treat osteoporosis in postmenopausal women. PROTELOS reduces the risk of fracture at the spine and at the hip.

About osteoporosis

Your body is constantly breaking down old bone and making new bone tissue. If you have osteoporosis, your body breaks down more bone than it forms so that gradually bone loss occurs and your bones become thinner and fragile. This is especially common in women after the menopause

Many people with osteoporosis have no symptoms and you may not even know that you have it. However, osteoporosis makes you more likely to have fractures (break bones), especially in your spine, hips and wrists.

How PROTELOS works

PROTELOS, which contains the substance strontium ranelate, belongs to a group of medicines used to treat bone diseases.

PROTELOS works by reducing bone breakdown and stimulating rebuilding of bone and therefore reduces the risk of fracture. The newly formed bone is of normal quality.

Before You Take Protelos Do not take PROTELOS: if you are allergic (hypersensitive) to strontium ranelate or any of the other ingredients of PROTELOS. Take special care with PROTELOS:

Before taking PROTELOS talk to your doctor:

if you have severe kidney disease. if you are being treated or have been treated for blood clots. if you are confined to bed or if you are to undergo an operation. The risk of vein thrombosis (blood clots in the leg) may be increased in the event of lengthy immobilisation. PROTELOS is not intended for use in children and adolescents (below the age of 18).

During treatment, if you experience an allergic reaction (such as swelling of the face, tongue or throat, difficulty in breathing or swallowing, skin rash), you must immediately stop taking PROTELOS and seek medical advice. If you have stopped treatment due to hypersensitivity reactions it should be permanent and you should not re-start therapy with PROTELOS.

Taking other medicines:

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

You should stop taking PROTELOS if you have to take oral tetracyclines or quinolones (two types of antibiotics). You can take PROTELOS again when you have finished taking these antibiotics. If you are unsure about this ask your doctor or pharmacist. If you are taking medicines containing calcium, you should leave at least 2 hours before you take PROTELOS. If you take antacids (medicines to relieve heartburn) you should take them at least 2 hours after PROTELOS. If this is not possible, it is acceptable to take the two medicines at the same time. Taking PROTELOS with food and drink:

Food, milk and milk products reduce the absorption of strontium ranelate. It is recommended that you take PROTELOS in-between meals, preferably at bedtime at least two hours after food, milk or milk products or calcium supplements.

Pregnancy and breast-feeding:

PROTELOS is meant for use only in postmenopausal women.

Therefore, do not take PROTELOS during pregnancy or when you are breastfeeding. If you take it by accident during pregnancy or breastfeeding, stop taking it straight away and talk to your doctor.

Driving and using machines:

Protelos is unlikely to affect your ability to drive or use machines.

Important information about some of the ingredients of PROTELOS:

PROTELOS contains aspartame. If you suffer from phenylketonuria (a rare, hereditary disorder of the metabolism) talk to your doctor before you start to take this medicine.

How To Take Protelos

Always take PROTELOS exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

PROTELOS is for oral use.

The recommended dose is one 2g sachet a day.

It is recommended that you take PROTELOS at bedtime, preferably at least 2 hours after dinner. You may lie down immediately after taking PROTELOS if you wish.

Take the granules contained in the sachets as a suspension in a glass of water (see instructions below). PROTELOS can interact with milk and milk products, so it is important that you mix PROTELOS only with water to be sure it works properly.

Empty the granules from the sachet into a glass;

Add water;

Stir until the granules are evenly dispersed in the water.

Drink straight away. You should not leave it more than 24 hours before you drink it. If for some reason you cannot drink the medicine straight away, make sure you stir it again before drinking.

Your doctor may advise you to take calcium and vitamin D supplements in addition to PROTELOS. Do not take calcium supplements at bedtime, at the same time as PROTELOS.

Your doctor will tell you how long you should continue to take PROTELOS. Osteoporosis-therapy is usually required for a long period. It is important that you continue taking PROTELOS for as long as your doctor prescribes the medicine.

If you take more PROTELOS than you should:

If you take too many sachets of PROTELOS, tell your doctor or pharmacist. They may advise you to drink milk or take antacids to reduce the absorption of the active ingredient.

If you forget to take PROTELOS:

Do not take a double dose to make up for forgotten individual doses. Just carry on with the next dose at the normal time.

Protelos Side Effects

Like all medicines, PROTELOS can cause side effects, although not everybody gets them.

The frequency of possible side effects listed below is defined using the following convention:

very common (affects more than 1 user in 10)

common (affects 1 to 10 users in 100)

uncommon (affects 1 to 10 users in 1,000)

rare (affects 1 to 10 users in 10,000)

very rare (affects less than 1 user in 10,000)

not known (frequency cannot be estimated from the available data)

Common:

Nausea, diarrhoea, headache, skin irritation, memory troubles, fainting fit.

However, these effects were mild and short-lived and usually did not cause the patients to stop taking their treatment. Talk to your doctor if any effects become troublesome or persist.

Uncommon:

Blood clots, seizures.

Not known:

Vomiting, abdominal pain, oral irritation (such as mouth ulcers and gum inflammation), bone, muscle and/or joint pain, muscle cramps, hypersensitivity syndromes (allergic reactions including rash, a high temperature and increased levels of liver enzymes seen in blood tests), itching, hives, blistering, angioedema (such as swollen face, tongue or throat, difficulty in breathing or swallowing), swelling in limbs, feeling confused, bronchial hyperreactivity (symptoms include wheezing and shortness of breath).

In some cases very serious hypersensitivity reactions have been reported. Therefore you should immediately stop taking PROTELOS and see your doctor if you experience symptoms of angioedema or hypersensitivity syndrome.

If you have stopped treatment due to hypersensitivity syndrome, it should be permanent and you should not re-start therapy with PROTELOS.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

How To Store Protelos

Keep out of the reach and sight of children.

This medicinal product does not require any special storage conditions.

Do not use after the expiry date which is stated on the box and the sachet after EXP.

Once reconstituted in water, the suspension is stable for 24 hours. However, it is recommended to drink the suspension immediately after preparation (see section 3)

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Further Information What PROTELOS contains The active substance is strontium ranelate. Each sachet contains 2 g of strontium ranelate. The other ingredients are aspartame (E 951), maltodextrin, mannitol (E 421). What PROTELOS looks like and contents of the pack

PROTELOS is available in sachets containing yellow granules for oral suspension. PROTELOS is supplied in boxes of 7, 14, 28, 56, 84 or 100 sachets.

Not all pack sizes may be marketed.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder

Les Laboratoires Servier 22, rue Garnier 92200 Neuilly-sur-Seine France

Manufacturer

Les Laboratoires Servier Industrie 905, route de Saran 45520 Gidy France

For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder.

United Kingdom Servier Laboratories Ltd Tel: +44 (0)1753 666409

This leaflet was last approved in 01/2010

Detailed information on this medicine is available on the European Medicines Agency (EMEA) web site: http://www.emea.europa.eu

Norethindrone/Ethinyl Estradiol Chewable Tablets
Pronunciation: nor-ETH-in-drone/ETH-i-nil ES-tra-DYE-ol/FER-us FUE-ma-rateGeneric Name: Norethindrone/Ethinyl EstradiolBrand Name: Femcon Fe

Ibuprofeno MK

Ibuprofeno MK may be available in the countries listed below.

Ingredient matches for Ibuprofeno MK Ibuprofen

Ibuprofen is reported as an ingredient of Ibuprofeno MK in the following countries:

Belize Colombia Costa Rica Dominican Republic Ecuador El Salvador Guatemala Honduras Nicaragua Panama

International Drug Name Search

Coartem

Generic Name: Artemether and LumefantrineClass: AntimalarialsVA Class: AP101

Vitamin A/Vitamin D/Vitamin C
Pronunciation: VYE-ta-min A/VYE-ta-min D/VYE-ta-min CGeneric Name: Vitamin A/Vitamin D/Vitamin CBrand Name: Examples include Tri-Vitaminand Tri-Vi-Sol

Vivelle

Generic Name: estradiol transdermal (ess tra DYE ol tranz DERM al) Brand Names: Alora, Climara, Estraderm, Estradiol Patch, Menostar, Vivelle, Vivelle-Dot

What is Vivelle (estradiol transdermal)?

Estradiol is a form of estrogen, a female sex hormone the regulates many processes in the body.

Estradiol transdermal skin patches are used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area. Estradiol transdermal also reduces urgency or irritation of urination.

Estradiol skin patches are also used to treat ovarian disorders, infertility, and abnormal vaginal bleeding. Some estradiol skin patches are used to prevent postmenopausal osteoporosis. Transdermal skin patches release the drug slowly, and it is absorbed through your skin.

Estradiol transdermal may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Vivelle (estradiol transdermal)? Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, a bleeding disorder, a hormone-related cancer such as breast or uterine cancer, or abnormal vaginal bleeding. This medication can cause birth defects in an unborn baby. Do not use if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol transdermal.

Long-term estradiol treatment may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol transdermal.

The estradiol transdermal patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging). Remove the patch before undergoing such a test. What should I discuss with my healthcare provider before using Vivelle (estradiol transdermal)? Do not use estradiol transdermal if you have:

a bleeding or blood-clotting disorder;

a history of stroke or circulation problems;

abnormal vaginal bleeding that a doctor has not checked; or

any type of breast, uterine, or hormone-dependent cancer.

To make sure you can safely use estradiol transdermal, tell your doctor if you have any of these other conditions:

high blood pressure, angina, or heart disease;

high cholesterol or triglycerides;

liver disease; kidney disease;

asthma;

epilepsy or other seizure disorder;

migraines;

diabetes;

depression;

gallbladder disease; or

if you have had your uterus removed (hysterectomy).

Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using estradiol transdermal.

Long-term estradiol treatment may increase your risk of stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

FDA pregnancy category X. This medication can cause birth defects. Do not use estradiol transdermal if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Estradiol can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby. How should I use Vivelle (estradiol transdermal)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Apply the skin patch to clean, dry skin on your stomach, lower back, or buttocks. Choose a different spot within these skin areas each time you apply a new patch. Avoid skin that is oily, irritated, or damaged.

Press the patch in place firmly for about 10 seconds, especially around the edges.

Do not apply a skin patch to your breasts. Do not apply a patch where it might be rubbed off by tight clothing, such as under an elastic waistband.

If a patch falls off, try putting it back on to a different skin area, pressing the patch into place for 10 seconds. If the patch will not stick you may apply a new one.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using estradiol transdermal.

The estradiol transdermal patch may burn your skin if you wear the patch during an MRI (magnetic resonance imaging). Remove the patch before undergoing such a test. Store at room temperature away from moisture and heat. What happens if I miss a dose?

Apply a skin patch as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra patches to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and vaginal bleeding.

What should I avoid while using Vivelle (estradiol transdermal)?

Avoid using other estrogen products without your doctor's advice.

Grapefruit and grapefruit juice may interact with estradiol and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Vivelle (estradiol transdermal) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

sudden numbness or weakness, especially on one side of the body;

sudden severe headache, confusion, problems with vision, speech, or balance;

pain or swelling in your lower leg;

abnormal vaginal bleeding;

pain, swelling, or tenderness in your stomach;

jaundice (yellowing of the skin or eyes); or

a lump in your breast.

Less serious side effects may include:

nausea, vomiting, loss of appetite;

swollen breasts;

acne or skin color changes;

decreased sex drive, impotence, or difficulty having an orgasm;

migraine headaches or dizziness;

vaginal pain, dryness, or discomfort;

swelling of your ankles or feet;

depression; or

changes in your menstrual periods, break-through bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Vivelle (estradiol transdermal)?

Tell your doctor about all other medicines you use, especially:

carbamazepine (Carbatrol, Equetro, Tegretol);

phenobarbital (Luminal, Solfoton);

St. John's wort;

a blood thinner such as warfarin (Coumadin, Jantoven);

an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifampin (Rifadin, Rifater, Rifamate, Rimactane), or telithromycin (Ketek);

antifungal medication such as itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), miconazole (Oravig), or voriconazole (Vfend); or

ritonavir (Norvir, Kaletra) and other HIV/AIDS medications.

This list is not complete and other drugs may interact with estradiol transdermal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Vivelle resources Vivelle Side Effects (in more detail)Vivelle Use in Pregnancy & BreastfeedingVivelle Drug InteractionsVivelle Support Group2 Reviews for Vivelle - Add your own review/rating Vivelle Advanced Consumer (Micromedex) - Includes Dosage Information Vivelle Patch MedFacts Consumer Leaflet (Wolters Kluwer) Vivelle Prescribing Information (FDA) Estradiol Monograph (AHFS DI) Estradiol Professional Patient Advice (Wolters Kluwer) Estradiol Prescribing Information (FDA) Estradiol MedFacts Consumer Leaflet (Wolters Kluwer) estradiol Transdermal Advanced Consumer (Micromedex) - Includes Dosage Information Alora Prescribing Information (FDA) Climara Prescribing Information (FDA) Climara Consumer Overview Climara Weekly Patch MedFacts Consumer Leaflet (Wolters Kluwer) Delestrogen MedFacts Consumer Leaflet (Wolters Kluwer) Delestrogen Prescribing Information (FDA) Depo-Estradiol MedFacts Consumer Leaflet (Wolters Kluwer) Depo-Estradiol Prescribing Information (FDA) Estrace Prescribing Information (FDA) Estrace MedFacts Consumer Leaflet (Wolters Kluwer) Estrace Consumer Overview Estrace Advanced Consumer (Micromedex) - Includes Dosage Information Estraderm Prescribing Information (FDA) Estradiol Patch Prescribing Information (FDA) Estrasorb Emulsion MedFacts Consumer Leaflet (Wolters Kluwer) Estrasorb Consumer Overview Estrasorb Prescribing Information (FDA) Evamist Prescribing Information (FDA) Evamist Consumer Overview Evamist Spray MedFacts Consumer Leaflet (Wolters Kluwer) Femring Prescribing Information (FDA) Femring Ring MedFacts Consumer Leaflet (Wolters Kluwer) Femtrace Prescribing Information (FDA) Femtrace Consumer Overview Femtrace Advanced Consumer (Micromedex) - Includes Dosage Information Femtrace MedFacts Consumer Leaflet (Wolters Kluwer) Menostar Consumer Overview Menostar Prescribing Information (FDA) Menostar Weekly Patch MedFacts Consumer Leaflet (Wolters Kluwer) Vivelle-Dot Prescribing Information (FDA) Compare Vivelle with other medications Atrophic UrethritisAtrophic VaginitisHypoestrogenismOophorectomyOsteoporosisPostmenopausal SymptomsPrimary Ovarian Failure Where can I get more information? Your pharmacist can provide more information about estradiol transdermal.

See also: Vivelle side effects (in more detail)

Pegvisomant
Pronunciation: peg-VI-soe-mantGeneric Name: PegvisomantBrand Name: Somavert

Famciclovir 125mg, 250mg, 500mg, 750mg Film-coated Tablets

Famciclovir 125mg, 250mg, 500mg, 750mg film-coated tablets

Read all of this leaflet carefully before you start using this medicine. Keep this leaflet. You may need to read it again. If you have any further questions, ask your doctor or pharmacist. This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. In this leaflet: 1. What famciclovir is and what it is used for 2. Before you use famciclovir 3. How to use famciclovir 4. Possible side effects 5. How to store famciclovir 6. Further information What Famciclovir Is And What It Is Used For

Famciclovir belongs to a group of medicines called antiviral agents. These are medicines used in the treatment of infections caused by viruses.

Famciclovir is used in patients with a normal immune system to treat attacks of genital herpes. Genital herpes is a viral infection which is normally spread by sexual contact. It causes blisters and burning around your genitals, which may be painful.

It is also sometimes used to prevent further episodes of genital herpes in patients with a normal immune system.

Famciclovir is used in the treatment of shingles in both patients with a normal immune system and in patients with a weakened immune system. Shingles is caused by a virus called herpes zoster or varicella zoster.

It is used in the treatment of herpes zoster infections of the eye in patients with a normal immune system.

Famciclovir is used in patients with a weakened immune system for the treatment of infections caused by herpes simplex virus, such as genital herpes or fever blisters (herpes labialis).

Before You Use Famciclovir Do not use famciclovir if you are allergic (hypersensitive) to famciclovir, penciclovir or any of the other ingredients of famciclovir. Take special care with famciclovir if you have kidney problems. You should talk with your doctor before you begin treatment with famciclovir, as it may be necessary to adjust your dosage.

As genital herpes is a sexually transmitted disease, you should avoid sexual activity if you have any symptoms of herpes, even if you have started treatment, to reduce the risk of spreading the disease to your partner. You should also take appropriate steps for protected intercourse if you are on long-term treatment with famciclovir for the same reason. Patients should therefore take appropriate steps for protected intercourse (i.e. use condoms).

Consult your doctor if one of the above-mentioned warnings applies to you, or has applied to you in the past.

Using other medicines

Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

If you are taking other medicines at the same time as famciclovir, these medicines may interfere with each other. This might be harmful. The effects of the medicines could be increased or diminished and side effects could occur more easily.

In particular this applies to:

probenecid, a medicine against viruses and gout some painkillers such as acetylsalicylic acid and ibuprofen Using famciclovir with food and drink

Famciclovir can be taken with or without food. Swallow the tablets with water.

Pregnancy and breast-feeding

Pregnancy

It is not known if it is safe to use famciclovir during pregnancy. Famciclovir must not be used during pregnancy, unless it is absolutely necessary and only in accordance with your doctor's instructions.

Breast-feeding

There is limited experience with famciclovir in breast-feeding women. Therefore, it should not be used during breast-feeding unless you are directly instructed to do so by your doctor.

Ask your doctor or pharmacist for advice before taking any medicine.

Driving and using machines

In rare instances, use of famciclovir may have side effects, such as dizziness, drowsiness and confusion.

If you experience any such side effects then do not drive or operate machinery.

How To Use Famciclovir

Always use famciclovir exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

Treatment with famciclovir should start as soon as possible after the symptoms of eruption/rash appear.

You should keep taking the medicine even if there is no improvement, as it may take several days for the medicine to work.

Keep taking the tablets until you have used the whole pack, unless your doctor has given you other instructions. Use lower dosage strength tablets, where these are available.

Adults

Recurrent genital herpes infection in patients with a normal immune system: 250mg twice daily.

In the treatment of genital herpes, you should start taking famciclovir as soon as possible after the occurrence of the first symptoms (pain, burning sensation, blisters).

First outbreak of genital herpes in patients with a normal immune system: 250mg three times daily.

In the treatment of genital herpes, you should start taking famciclovir as soon as possible after the occurrence of the first symptoms (pain, burning sensation, blisters).

Prevention of further recurrences of genital herpes in patients with a normal immune system: one 250mg tablet twice daily.

Prevention of recurring outbreak of genital herpes in HIV patients: 500mg twice daily.

Genital herpes infection in patients with a weakened immune system: 500mg twice daily.

In the treatment of genital herpes, you should start taking famciclovir as soon as possible after the occurrence of the first symptoms (pain, burning sensation, blisters).

Fever blisters in patients with a weakened immune system: 500mg twice daily.

In the treatment of a fever blister (herpes labialis), you should start taking famciclovir as soon as possible after the occurrence of the first symptoms of the infection (pain, burning sensation, blisters).

Shingles in patients with a normal immune system: 500mg three times daily.

In the treatment of shingles (herpes zoster), you should start taking famciclovir as soon as possible (within 48 hours) after the occurrence of the first symptoms of the infection (rash).

Herpes zoster infection of the eye in patients with a normal immune system: 500mg three times daily or 750mg twice daily* for 7 days.

* Only relevant for the 750mg strength.

Shingles in patients with a weakened immune system: 500mg three times daily.

In the treatment of shingles (herpes zoster), you should start taking famciclovir as soon as possible (within 48 hours) after the occurrence of the first symptoms of the infection (rash).

Patients with kidney problems

Depending on how severely the function of your kidneys is affected, your doctor may reduce the dose of famciclovir you must take.

Elderly patients

Your doctor may adjust your dosage of famciclovir according to your kidney function.

Children

Famciclovir is not recommended for use in children below 18 years of age due to lack of data on safety and efficacy.

Duration of treatment

Treatment of genital herpes in patients with a normal immune system: 5 days.

Treatment of genital herpes in patients with a weakened immune system: 7 days.

Prevention of recurrence of genital herpes in patients with a normal immune system: 6-12 months. You should only take famciclovir for as long as your doctor has told you.

Shingles in patients with a normal immune system: 7 days.

Shingles in patients with a weakened immune system: 10 days.

Fever blisters in patients with a weakened immune system: 7 days.

If you use more famciclovir than you should

Contact your doctor or pharmacist if you have taken more famciclovir than stated in this leaflet, or more than the doctor has prescribed.

Rarely, acute kidney failure has occurred in patients with existing kidney disease when the dose of famciclovir was not adjusted accordingly.

If you forget to use famciclovir

If you forget to take the medicine, take it as soon as you remember, or skip the forgotten tablet if it is time for your next dose. Then continue taking the tablets as normal.

Do not take a double dose to make up for a forgotten dose. If you have forgotten several doses, you should contact your doctor.

If you stop using famciclovir

Do not stop taking famciclovir without consulting your doctor first.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Possible Side Effects

Like all medicines, famciclovir can cause side effects, although not everybody gets them.

The following side effects may occur:

Common side effects (occur in 1 to 10 users in 100)

Headache Nausea, diarrhoea, vomiting, abdominal pain, constipation Increased sweating Itching

Rare side effects (occur in 1 to 10 users in 10,000)

Confusion (mainly in elderly patients)

Very rare effects (occur in less than 1 user in 10,000)

Blood disorders (shortage of blood cells, called blood platelets that help blood to clot) accompanied by bruises and proneness to bleeding (so-called thrombocytopenia) Hallucinations (seeing and hearing things that are not really there) Dizziness, fatigue (tiredness), drowsiness (primarily in elderly patients) Yellowing of the skin and eyes (jaundice) Abnormal liver function tests Severe skin reactions, such as serious allergic reactions (hypersensitivity) with (high) temperature, dark red patches on the skin, joint pains and/or eye infections (so-called Stevens-Johnson syndrome), acute severe (hypersensitivity) reactions associated with fever and blisters on the skin, shedding of skin (so-called toxic epidermal necrolysis) or rash with reddish (weeping) irregular patches (so-called erythema multiforme); rash, nettle rash

Not known (cannot be estimated from the available data)

Fever

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

How To Store Famciclovir

Keep out of the reach and sight of children.

Do not store above 30°C.

Store in the original package to protect from moisture.

Do not use famciclovir after the expiry date which is stated on the carton after EXP. The expiry date refers to the last day of that month.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Further Information What Famciclovir Tablets contain

The active substance is famciclovir.

125mg tablet: each tablet contains 125mg of famciclovir.

250mg tablet: each tablet contains 250mg of famciclovir.

500mg tablet: each tablet contains 500mg of famciclovir.

750mg tablet: each tablet contains 750mg of famciclovir.

The other ingredients are:

Tablet core: Starch Pregelatinised, Sodium Laurilsulfate, Cellulose, Microcrystalline, Croscarmellose Sodium, Silica Colloidal Anhydrous, Stearic acid.

Film-coating:

Hypromellose (E464), Titanium Dioxide (E171), Macrogol 4000, Macrogol 6000.

What Famciclovir Tablets look like and contents of the pack

125mg film-coated tablets: white, round, biconvex, film-coated tablets with diameter of 7.6mm approximately.

250mg film-coated tablets: white, round, biconvex, film-coated tablets, scored on one side with diameter of 10.6mm approximately.

500mg film-coated tablets: white, oval, film-coated tablets, scored on both sides with dimensions of 18.2 x 8.6mm approximately.

750mg film-coated tablets: white, oval, film-coated tablets with dimensions of 20.5 x 9.8mm approximately.

250mg and 500mg film-coated tablets: The tablet can be divided into equal halves. Use lower strength tablets where these are available.

Famciclovir Tablets are available in blister packs of:

125mg: 10 tablets 250mg: 15, 21, 56 tablets 500mg: 14, 30, 56 tablets

Other immunosuppressants

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

See also

Medical conditions associated with other immunosuppressants:

Acute Lymphoblastic LeukemiaAcute Lymphocytic LeukemiaAcute Nonlymphocytic LeukemiaAnemiaAsthma, MaintenanceAtopic DermatitisAutoimmune HepatitisBehcet's DiseaseBiliary CirrhosisBladder CancerBrain TumorBreast CancerBullous PemphigoidCervical CancerChoriocarcinomaChronic Active HepatitisChronic Inflammatory Demyelinating PolyradiculoneuropathyCogan's SyndromeColorectal CancerCrohn's DiseaseCrohn's Disease, AcuteCrohn's Disease, MaintenanceDermatomyositisEctopic PregnancyEczemaEsophageal CarcinomaGastric CancerGlomerulonephritisGraft-versus-host diseaseHead and Neck CancerHodgkin's LymphomaIdiopathic Thrombocytopenic PurpuraInflammatory Bowel DiseaseLeprosy, Erythema Nodosum LeprosumLymphomaMeningeal LeukemiaMultiple MyelomaMultiple SclerosisMyasthenia GravisMycosis FungoidesMyopathyNeoplastic DiseasesNephrotic SyndromeNeurosarcoidosisNon-Hodgkin's LymphomaNon-Small Cell Lung CancerOrgan Transplant, Rejection ProphylaxisOsteosarcomaOvarian CancerPancreatic CancerPemphigoidPemphigusPityriasis rubra pilarisPsoriasisPsoriatic ArthritisRenal TransplantRheumatoid ArthritisSarcoidosisSmall Cell Lung CancerSoft Tissue SarcomaSolid TumorsSystemic Lupus ErythematosusSystemic SclerosisTakayasu's ArteritisTrophoblastic DiseaseUlcerative ColitisUveitis Drug List:XolairImuranThalomidTrexall

Tretin-X Gel
Pronunciation: TRET-i-noinGeneric Name: TretinoinBrand Name: Tretin-X

Trihexyphenidyl Hydrochloride

Class: Anticholinergic AgentsVA Class: AU350CAS Number: 52-49-3

Tofranil

Generic Name: imipramine (im IP ra meen) Brand Names: Tofranil, Tofranil-PM

What is Tofranil (imipramine)?

Imipramine is in a group of drugs called tricyclic antidepressants. Imipramine affects chemicals in the brain that may become unbalanced.

Imipramine is used to treat symptoms of depression.

Imipramine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Tofranil (imipramine)? Do not use imipramine if you have recently had a heart attack, or if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. What should I discuss with my healthcare provider before taking Tofranil (imipramine)? Do not use this medication if you are allergic to imipramine, or if you have recently had a heart attack. Do not use imipramine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take imipramine before the MAO inhibitor has cleared from your body.

Before taking imipramine, tell your doctor if you are allergic to any drugs, or if you have:

heart disease;

a history of heart attack, stroke, or seizures;

bipolar disorder (manic-depression);

kidney or liver disease;

overactive thyroid;

diabetes (imipramine may raise or lower blood sugar);

adrenal gland tumor (pheochromocytoma);

glaucoma; or

problems with urination.

If you have any of these conditions, you may not be able to use imipramine, or you may need a dosage adjustment or special tests during treatment.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Imipramine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to anyone younger than 18 years old without the advice of a doctor. How should I take Tofranil (imipramine)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from this medication. Follow the directions on your prescription label.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking imipramine. You may need to stop using the medicine for a short time.

Do not stop using imipramine without first talking to your doctor. You may need to use less and less before you stop the medication completely. Stopping this medication suddenly could cause you to have unpleasant side effects. It may take up to 3 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 3 weeks of treatment. Store imipramine at room temperature away from moisture and heat. What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. An overdose of imipramine can be fatal.

Symptoms of an imipramine overdose may include uneven heartbeats, extreme drowsiness, agitation, vomiting, blurred vision, sweating, muscle stiffness, swelling, shortness of breath, blue lips or fingernails, feeling light-headed, fainting, seizure (convulsions), or coma.

What should I avoid while taking Tofranil (imipramine)? Avoid drinking alcohol. It can cause dangerous side effects when taken together with imipramine.

Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, medicine for seizures, or other antidepressants). They can add to sleepiness caused by imipramine.

Grapefruit and grapefruit juice may interact with imipramine. Discuss the use of grapefruit products with your doctor before increasing or decreasing the amount of grapefruit products in your diet.

Imipramine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Imipramine can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun. Tofranil (imipramine) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

fast, pounding, or uneven heart rate;

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

sudden numbness or weakness, especially on one side of the body;

sudden headache, confusion, problems with vision, speech, or balance;

feeling short of breath, even with mild exertion;

swelling, rapid weight gain;

confusion, hallucinations, or seizure (convulsions);

easy bruising or bleeding, unusual weakness;

restless muscle movements in your eyes, tongue, jaw, or neck;

urinating more or less than usual;

extreme thirst with headache, nausea, vomiting, and weakness;

skin rash, bruising, severe tingling, numbness, pain, or muscle weakness.

Less serious side effects may be more likely to occur, such as:

nausea, vomiting, stomach pain, loss of appetite;

constipation or diarrhea;

dry mouth, unpleasant taste;

weight changes;

weakness, lack of coordination;

feeling dizzy, drowsy, or tired;

nightmares;

blurred vision, headache, ringing in your ears;

breast swelling (in men or women); or

decreased sex drive, impotence, or difficulty having an orgasm.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Tofranil (imipramine)?

Before taking imipramine, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft).

Before taking imipramine, tell your doctor if you are currently using any of the following drugs:

cimetidine (Tagamet);

clonidine (Catapres);

guanethidine (Ismelin);

methylphenidate (Concerta, Ritalin, Daytrana); or

heart rhythm medications such as flecainide (Tambocor), propafenone (Rhythmol), or quinidine (Cardioquin, Quinidex, Quinaglute).

If you are using any of these drugs, you may not be able to use imipramine, or you may need dosage adjustments or special tests during treatment.

There are many other medicines that can interact with imipramine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

More Tofranil resources Tofranil Side Effects (in more detail)Tofranil Use in Pregnancy & BreastfeedingDrug ImagesTofranil Drug InteractionsTofranil Support Group9 Reviews for Tofranil - Add your own review/rating Tofranil MedFacts Consumer Leaflet (Wolters Kluwer) Tofranil Advanced Consumer (Micromedex) - Includes Dosage Information Tofranil Prescribing Information (FDA) Imipramine Professional Patient Advice (Wolters Kluwer) Imipramine Prescribing Information (FDA) Imipramine Hydrochloride Monograph (AHFS DI) Tofranil-PM Prescribing Information (FDA) Tofranil-PM MedFacts Consumer Leaflet (Wolters Kluwer) Compare Tofranil with other medications ADHDDepressionInterstitial CystitisNight TerrorsPainPanic DisorderPrimary Nocturnal Enuresis Where can I get more information? Your pharmacist has information about imipramine written for health professionals that you may read.

See also: Tofranil side effects (in more detail)

Suprane

Generic Name: desflurane (Inhalation route)

des-FLOO-rane

Commonly used brand name(s)

In the U.S.

Suprane

Available Dosage Forms:

Liquid Solution

Therapeutic Class: Volatile Liquid

Chemical Class: Haloalkane

Uses For Suprane

Desflurane belongs to the group of medicines known as general anesthetics. Desflurane is used to cause general anesthesia (loss of consciousness) before and during surgery. It is breathed in (inhaled). Although desflurane can be used by itself, combinations of anesthetics are often used together. This helps produce more effective anesthesia in some patients.

General anesthetics are given only by or under the immediate supervision of a medical doctor trained to use them. If you will be receiving a general anesthetic during surgery, your doctor will give you the medicine and closely follow your progress.

Before Using Suprane

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Desflurane has been tested in children. It is not used to start anesthesia in children who are awake because it causes irritation and other unwanted effects. However, when it is used to continue general anesthesia that has been started with another anesthetic, desflurane does not cause different side effects or problems in children than it does in adults.

Geriatric

Desflurane has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults. However, older people usually need smaller amounts of an anesthetic than younger people. Your doctor will take your age into account when deciding on the right amount of desflurane for you.

Pregnancy Pregnancy Category Explanation All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Cisatracurium Hydromorphone Oxycodone St John's Wort Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

The presence of other medical problems may affect the use of desflurane. Make sure you tell your doctor if you have any other medical problems, especially:

Diseases that can cause muscle weakness, such as familial periodic paralysis, muscular dystrophy, myasthenia gravis, or Eaton-Lambert syndrome, or Heart or blood vessel disease—The chance of side effects may be increased, but serious problems can be prevented if your doctor knows that these conditions are present before giving you an anesthetic Malignant hyperthermia, during or shortly after receiving an anesthetic (history of, or family history of). Signs of malignant hyperthermia include very high fever, fast and irregular heartbeat, muscle spasms or tightness, and breathing problems—This side effect may occur again Proper Use of Suprane Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Your age. Your general physical condition. The kind of surgery being performed. Other medicines you are taking or will receive before and during surgery. Precautions While Using Suprane

For patients going home within 24 hours after receiving a general anesthetic:

General anesthetics may cause some people to feel drowsy, tired, or weak for a while after they have been given. They may also cause problems with coordination and one's ability to think. Therefore, for about 24 hours (or longer if necessary) after receiving a general anesthetic, do not drive, use machines, or do anything else that could be dangerous if you are not alert. Unless otherwise directed by your doctor or dentist, do not drink alcoholic beverages or take other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness) for about 24 hours after you have received a general anesthetic. To do so may add to the effects of the anesthetic. Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; other sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; and muscle relaxants. Suprane Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Coughing nausea or vomiting Less common or rare Dizziness headache irritated or red eyes nervousness and restlessness sore throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Suprane side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Suprane resources Suprane Side Effects (in more detail)Suprane Use in Pregnancy & BreastfeedingSuprane Drug InteractionsSuprane Support Group0 Reviews for Suprane - Add your own review/rating Suprane Prescribing Information (FDA) Desflurane Compare Suprane with other medications Anesthesia

Clomicalm
Dosage Form: FOR ANIMAL USE ONLYClomicalm Caution:

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Description:

Clomicalm (clomipramine hydrochloride) Tablets belong to the dibenzazepine class of tricyclic antidepressants. Clomipramine hydro-chloride is 3-chloro-5[3-(dimethyl-amino)propyl]-10,11dihydro-5H dibenz[b,f]azepine monohydrochloride. Clomicalm Tablets are oblong, light brown in color and contain clomipramine hydrochloride formulated together with meat components. The molecular weight of clomipramine hydrochloride is 351.3. The structural formula is:

Clinical Pharmacology:

Clomipramine hydrochloride reduces the clinical signs of separation anxiety by affecting serotonergic and noradrenergic neuronal transmission in the central nervous system. While clomipramine hydrochloride can cause lethargy in dogs (see Adverse Reactions) its mode of action is not as a sedative. Clomipramine hydrochloride’s capacity to inhibit re-uptake of serotonin in the central nervous system is believed to be the primary mechanism of action. Clomipramine hydrochloride is rapidly absorbed when administered orally. A single-dose crossover study involving 12 dogs evaluated clomipramine hydrochloride bioavailability after IV (2 mg/kg) and oral (4 mg/kg) administration in either a fed or fasted state. The administration of clomipramine hydrochloride in the presence of food resulted in an increase in the rate and extent of drug absorption as shown in the following table (mean ±SD):

AUC0-inf

Hair Regrowth Treatment for Women
minoxidil Dosage Form: topical solutionCVS Pharmacy, Inc. Hair Regrowth Treatment for Women Drug Facts Active ingredient

Minoxidil 2% w/v

Purpose

Hair regrowth treatment

Uses

to regrow hair on the scalp

Warnings

For external use only

Flammable: Keep away from fire or flame

Do not use if your degree of hair loss is different than that shown on the side of this carton, because this product may not work for you you have no family history of hair loss your hair loss is sudden and/or patchy your hair loss is associated with childbirth you do not know the reason for your hair loss you are under 18 years of age. Do not use on babies and children. your scalp is red, inflamed, infected, irritated, or painful you use other medicines on the scalp Ask a doctor before use if you have

heart disease

When using this product do not apply on other parts of the body avoid contact with the eyes. In case of accidental contact, rinse eyes with large amounts of cool tap water. some people have experienced changes in hair color and/or texture it takes time to regrow hair. You may need to use this product 2 times a day for at least 4 months before you see results. the amount of hair regrowth is different for each person. This product will not work for everyone. Stop use and ask a doctor if chest pain, rapid heartbeat, faintness, or dizziness occurs sudden, unexplained weight gain occurs your hands or feet swell scalp irritation or redness occurs unwanted facial hair growth occurs you do not see hair regrowth in 4 months May be harmful if used when pregnant or breast-feeding. Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

Directions apply one mL with dropper 2 times a day directly onto the scalp in the hair loss area using more or more often will not improve results continued use is necessary to increase and keep your hair regrowth, or hair loss will begin again Other information see hair loss pictures on side of this carton before use, read all information on carton and enclosed leaflet keep the carton. It contains important information. in clinical studies of mostly white women aged 18-45 years with mild to moderate degrees of hair loss, the following response to minoxidil topical solution 2% was reported: 19% of women reported moderate hair regrowth after using minoxidil topical solution 2% for 8 months (19% had moderate regrowth; 40% had minimal regrowth). This compares with 7% of women reporting moderate hair regrowth after using the placebo, the liquid without minoxidil in it, for 8 months (7% had moderate regrowth; 33% had minimal regrowth). store at 20° to 25°C (68° to 77°F). Keep tightly closed. Inactive ingredients

alcohol, propylene glycol, purified water

Questions or comments?

1-800-719-9260

Principal Display Panel

Hair Regrowth Treatment for Women

Minoxidil Topical Solution USP 2%

Hair Regrowth Treatment

Clinically Proven to Help Regrow Hair

Revitalizes Hair Follicles

Unscented

Compare to Women’s Rogaine® active ingredient

# Month Supply

Hair Regrowth Treatment for Women Carton - Left Side

Hair Regrowth Treatment for Women Carton - Right Side

Sanctura

Generic Name: Trospium ChlorideClass: Genitourinary Smooth Muscle RelaxantsVA Class: GU201

Pannaz S Syrup
Pronunciation: KAR-bin-OX-a-meen/METH-skoe-POL-a-meen/SOO-doe-e-FED-rinGeneric Name: Carbinoxamine/Methscopolamine/PseudoephedrineBrand Name: Examples include Pannaz S and Pseudox M

Azelex
azelaic acid Dosage Form: creamAzelex®

Hydrap-ES

Generic Name: hydralazine/hydrochlorothiazide/reserpine (hye DRAL a zeen/hye droe klor oh THYE a zide/re SER peen) Brand Names: Diuretic Ap-Es, Hydrap-ES, Ser-Ap-Es, Serpazide, Tri-Hydroserpine, Uni Serp

What is Hydrap-ES (hydralazine/hydrochlorothiazide/reserpine)?

Hydralazine is a vasodilator. It lowers blood pressure by relaxing (widening) blood vessels (veins and arteries) and making it easier for your heart to pump.

Hydrochlorothiazide is a thiazide diuretic (water pill). It helps to lower your blood pressure and decrease edema (swelling or water retention) by increasing the amount of salt and water you lose in your urine.

Reserpine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels (veins and arteries) to relax and your heart to beat more slowly and easily.

The combination, hydralazine/hydrochlorothiazide/reserpine, is used to lower high blood pressure.

Hydralazine/hydrochlorothiazide/reserpine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Hydrap-ES (hydralazine/hydrochlorothiazide/reserpine)? Stand up slowly from a sitting or lying position. Hydralazine/hydrochlorothiazide/reserpine may make you feel dizzy. Do not stop taking hydralazine/hydrochlorothiazide/reserpine suddenly. Even if you feel better, you need this medication to control your condition. Stopping suddenly could cause severely high blood pressure, anxiety, and other dangerous side effects. Use caution when driving, operating machinery, or performing other hazardous activities. Hydralazine/hydrochlorothiazide/reserpine may cause dizziness. If you experience dizziness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking this medication. What should I discuss with my healthcare provider before taking Hydrap-ES (hydralazine/hydrochlorothiazide/reserpine)? Do not take hydralazine/hydrochlorothiazide/reserpine without first talking to your doctor if you

have an allergy to sulfa-based drugs such as sulfa antibiotics;

have coronary heart disease or mitral valvular rheumatic heart disease;

have peptic ulcer disease (stomach ulcers);

have ulcerative colitis;

are suffering from depression (especially if you have suicidal thoughts);

are receiving electroconvulsive shock therapy; or

have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.

You may not be able to take hydralazine/hydrochlorothiazide/reserpine if you have any of the conditions listed above.

Before taking this medication, tell your doctor if you

have gallstones,

have kidney or liver disease,

have diabetes,

have gout,

have a collagen vascular disease such as systemic lupus erythematosus,

have pancreatitis,

have asthma,

have any type of heart disease,

have had a stroke or a transient ischemic attack (mini-stroke),

have high cholesterol or high levels of fat in your blood, or

have pulmonary hypertension (a type of lung disease).

You may require a dosage adjustment or special monitoring during therapy with hydralazine/hydrochlorothiazide/reserpine if you have any of the conditions listed above.

Hydralazine/hydrochlorothiazide/reserpine is in the FDA pregnancy category C. This means that it is not known whether hydralazine/hydrochlorothiazide/reserpine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. Hydralazine/hydrochlorothiazide/reserpine passes into breast milk and may harm a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from hydralazine/hydrochlorothiazide/reserpine therapy. You may require a lower dose of this medication. How should I take Hydrap-ES (hydralazine/hydrochlorothiazide/reserpine)?

Take the medication exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Take the medication with food or milk if it upsets your stomach.

Do not suddenly stop taking hydralazine/hydrochlorothiazide/reserpine. Stopping suddenly could make your condition much worse or cause very serious side effects. Talk to your doctor before you stop taking this medication.

Store this medication at room temperature away from moisture and heat. What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose? Seek emergency medical attention.

Symptoms of an overdose include low blood pressure (fainting, dizziness, weakness), slow pulse or an irregular heartbeat, low body temperature, diarrhea, increased urination, vomiting, headache, flushing of the skin, and slow breathing.

What should I avoid while taking Hydrap-ES (hydralazine/hydrochlorothiazide/reserpine)? Use caution when driving, operating machinery, or performing other hazardous activities. This medicine may cause dizziness. If you experience dizziness, avoid these activities. Avoid alcohol while taking hydralazine/hydrochlorothiazide/reserpine. Alcohol may increase the drowsiness caused by this medication and may increase dizziness. Use caution even with small amounts of alcohol. Use caution when rising from a sitting or lying position, especially first thing in the morning. You may become dizzy while taking hydralazine/hydrochlorothiazide/reserpine, and you may fall and injure yourself.

Do not let yourself become overheated in hot weather or during exercise, and use caution if you have a fever. Dehydration may increase the effects of hydralazine/hydrochlorothiazide/reserpine, and you may become very dizzy.

Avoid prolonged exposure to sunlight. Hydrochlorothiazide may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable. Hydrap-ES (hydralazine/hydrochlorothiazide/reserpine) side effects If you experience any of the following serious side effects, stop taking hydralazine/hydrochlorothiazide/reserpine and seek emergency medical attention:

an allergic reaction (difficulty breathing, closing of your throat, swelling of your lips, tongue or face, hives);

irregular or fast heartbeats or a fluttering feeling in your chest;

new or worsening chest pain;

heart failure (shortness of breath, swelling of ankles or legs, sudden weight gain of 2 pounds in one day or 5 pounds in one week);

unusual fatigue or confusion;

abnormal bleeding or bruising;

yellow skin or eyes;

blood in your urine or stools;

little or no urine;

numbness, tingling, pain, or weakness of your arms or legs; or

fainting.

Other, less serious side effects are more likely to occur. Continue to take hydralazine/hydrochlorothiazide/reserpine and talk to your doctor if you experience

mild fatigue, drowsiness, or dizziness;

headache;

water retention (swelling of the hands, feet, or ankles);

anxiety, depression, or nightmares;

diarrhea, nausea, vomiting , abdominal pain;

stuffy nose or a dry mouth;

muscle weakness or cramps;

increased hunger, thirst, or urination;

a rash;

sensitivity to sunlight; or

impotence or difficulty ejaculating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Hydrap-ES (hydralazine/hydrochlorothiazide/reserpine)?

Do not take this medication if you have taken a monoamine oxidase inhibitor (MAOI), such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate), in the last 14 days.

Before taking this medication, tell your doctor if you are taking any of the following drugs:

digoxin (Lanoxin, Lanoxicaps);

quinidine (Cardioquin, others);

lithium (Lithobid, Eskalith, others);

a tricyclic antidepressant such as amitriptyline (Elavil, Endep), imipramine (Tofranil), nortriptyline (Pamelor), doxepin (Sinequan), and others; a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Anaprox, Aleve), and others;

an antidiabetic medicine such as glipizide (Glucotrol), glyburide (Micronase, Glynase, Diabeta), and others; or

a steroid medicine such as prednisone (Orasone, Deltasone), prednisolone (Delta Cortef, Prelone), methylprednisolone (Medrol), and others.

You may not be able to take hydralazine/hydrochlorothiazide/reserpine, or you may require a dosage adjustment or special monitoring during your treatment if you are taking any of the medicines listed above.

Also, before taking hydralazine/hydrochlorothiazide/reserpine, tell your doctor if you are taking any medicine to treat high blood pressure, water retention, heart problems, prostate problems, or another condition. Some medicines used to treat these conditions may interact with hydralazine/hydrochlorothiazide/reserpine, and the interaction may increase the effects on your heart.

Hydralazine/hydrochlorothiazide/reserpine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

Drugs other than those listed here may also interact with hydralazine/hydrochlorothiazide/reserpine or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More Hydrap-ES resources Hydrap-ES Side Effects (in more detail)Hydrap-ES Use in Pregnancy & BreastfeedingHydrap-ES Drug InteractionsHydrap-ES Support Group0 Reviews for Hydrap-ES - Add your own review/rating Ser-Ap-Es Prescribing Information (FDA) Compare Hydrap-ES with other medications High Blood Pressure Where can I get more information? Your pharmacist has additional information about hydralazine/hydrochlorothiazide/reserpine written for health professionals that you may read. What does my medication look like?

Hydralazine/hydrochlorothiazide/reserpine is available with a prescription under the brand name Ser-Ap-Es. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Hydralazine/hydrochlorothiazide/reserpine strengths are as follows:

Ser-Ap-Es (25 mg/15 mg/0.1mg)--round, salmon-pink, dry-coated tablets

See also: Hydrap-ES side effects (in more detail)

Fluticasone HFA Aerosol Inhaler
Pronunciation: floo-TIK-a-soneGeneric Name: Fluticasone HFABrand Name: Flovent HFA

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