Chlorpheniramine/Phenylephrine Suspension
Pronunciation: klor-fen-IHR-ah-meen/fen-il-EF-rinGeneric Name: Chlorpheniramine/PhenylephrineBrand Name: Examples include AlleRx and Ricobid NR

FazaClo

Generic Name: clozapine (KLOE za peen) Brand Names: Clozaril, FazaClo

What is clozapine?

Clozapine is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Clozapine is used to treat severe schizophrenia. Clozapine is also used to reduce the risk of suicidal behavior in people with schizophrenia or similar disorders. Clozapine is usually given after other medications have been tried without successful treatment of symptoms.

Clozapine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about clozapine? Clozapine is not for use in psychotic conditions related to dementia. Clozapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not take clozapine if you are allergic to it, or if you have untreated or uncontrolled epilepsy, a bone marrow disorder, paralytic ileus or intestinal blockage, a history of infection caused by taking clozapine, or if you are also using drugs that weaken your immune system (such as cancer medicine or steroids). Clozapine can lower blood cells that help your body fight infections. This can make it easier for you to develop a serious or life-threatening infection. This risk is higher in women and older adults, and in people who are malnourished or have serious medical problems. While you are taking clozapine, your blood will need to be tested often. Do not miss any follow-up visits to your doctor. Serious and sometimes fatal infections may occur during treatment with clozapine. Call your doctor right away if you have signs of infection such as: fever, chills, body aches, flu symptoms, mouth or throat ulcers, cough, sore throat, rapid heart rate, or rapid and shallow breathing.

There are many other medicines that can interact with clozapine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

What should I discuss with my healthcare provider before taking clozapine? Clozapine is not for use in psychotic conditions related to dementia. Clozapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not take clozapine if you are allergic to it, or if you have:

untreated or uncontrolled epilepsy;

a bone marrow disorder;

paralytic ileus or intestinal blockage;

a history of infection caused by taking clozapine; or

if you are also using drugs that weaken your immune system (such as cancer medicine or steroids).

To make sure you can safely take clozapine, tell your doctor if you have any of these other conditions:

heart disease, heart rhythm disorder, high blood pressure;

history of heart attack or stroke;

a personal or family history of Long QT syndrome;

epilepsy or other seizure disorder;

lung disease;

liver or kidney disease;

diabetes;

a history of bone marrow or blood cell disorders;

an enlarged prostate or urination problems;

glaucoma; or

if you smoke.

FDA pregnancy category B. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking clozapine, do not stop taking it without your doctor's advice. Clozapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking clozapine.

Clozapine orally-disintegrating tablets contain phenylalanine. Talk to your doctor before using this form of clozapine if you have phenylketonuria (PKU).

How should I take clozapine?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Clozapine can be taken with or without food.

Take the regular oral tablet (Clozaril) with a full glass of water.

The orally-disintegrating tablet (FazaClo) can be taken without water. Keep the tablet in its blister pack until you are ready to take it. Gently peel back the foil from the blister pack and drop the tablet onto your dry hand. Place the tablet in your mouth. It will begin to dissolve right away. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

If your doctor has prescribed one-half of an orally-disintegrating tablet, you will need to break the tablet in half. Throw the other half away. Do not save it for later use.

Clozapine can lower blood cells that help your body fight infections. This can make it easier for you to develop a serious or life-threatening infection. This risk is higher in women and older adults, and in people who are malnourished or have serious medical problems. While you are taking clozapine, your blood will need to be tested often. Your doctor may also want to check your blood for several weeks after you stop using clozapine. Do not miss any follow-up visits to your doctor. If you stop taking clozapine for more than 2 days in a row, call your doctor before you start taking it again. If you need surgery, tell the surgeon ahead of time that you are using clozapine. Store at room temperature away from moisture and heat. What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include drowsiness, confusion, fast heart rate, drooling, weak or shallow breathing, fainting, and seizure (convulsions). What should I avoid while taking clozapine? Clozapine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid drinking alcohol. It can increase some of the side effects of clozapine. Clozapine side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Serious and sometimes fatal infections may occur during treatment with clozapine. Call your doctor right away if you have signs of infection such as:

fever, chills, body aches, flu symptoms;

mouth and throat ulcers;

cough, sore throat;

rapid heart rate; or

rapid and shallow breathing.

Stop using clozapine and call your doctor at once if you have any of these serious side effects:

headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

seizure (black-out or convulsions);

skin rash, bruising, severe tingling, numbness, pain, muscle weakness;

unusual tiredness, trouble breathing;

feeling short of breath (even at night or with mild exertion), swelling in your hands or feet;

feeling like you might pass out;

slow heart rate, weak pulse, slow breathing (breathing may stop);

high blood sugar (increased thirst, extreme hunger, fruity breath odor, increased urination, drowsiness);

very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors;

twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; or

nausea, vomiting, loss of appetite, and jaundice (yellowing of your skin or eyes).

Less serious side effects may include:

constipation;

dry mouth, blurred vision;

drooling, especially at night;

increased sweating;

drowsiness, dizziness, spinning sensation; or

sleep problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect clozapine?

Many drugs can interact with clozapine. Below is just a partial list. Tell your doctor if you are using:

any other antipsychotic medication;

armodafinil (Nuvigil) or modafinil (Progivil);

arsenic trioxide (Trisenox);

bosentan (Tracleer);

cimetidine (Tagamet);

conivaptan (Vaprisol);

dexamethasone (Cortastat, Dexasone, Solurex, DexPak);

nefazodone;

imatinib (Gleevec);

isoniazid (for treating tuberculosis);

phenobarbital (Solfoton) and other barbiturates;

St. John's wort;

tacrolimus (Prograf);

an antibiotic or antifungal medication;

an antidepressant;

anti-malaria medications;

atropine (Donnatal, and others), belladonna, clidinium (Quarzan), dicyclomine (Bentyl), scopolamine (Transderm-Scop);

heart or blood pressure medication;

HIV/AIDS medication;

medicine to prevent or treat nausea and vomiting;

migraine headache medicine such as sumatriptan (Imitrex, Treximet);

narcotic medication such as methadone (Methadose, Diskets, Dolophine); or

seizure medication.

This list is not complete and there are many other drugs that can interact with clozapine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

More FazaClo resources FazaClo Side Effects (in more detail)FazaClo Use in Pregnancy & BreastfeedingDrug ImagesFazaClo Drug InteractionsFazaClo Support Group0 Reviews for FazaClo - Add your own review/rating FazaClo Prescribing Information (FDA) FazaClo Orally Disintegrating Tablets MedFacts Consumer Leaflet (Wolters Kluwer) FazaClo Advanced Consumer (Micromedex) - Includes Dosage Information Clozapine Prescribing Information (FDA) Clozapine MedFacts Consumer Leaflet (Wolters Kluwer) Clozapine Professional Patient Advice (Wolters Kluwer) Clozapine Monograph (AHFS DI) Clozaril Prescribing Information (FDA) Clozaril Consumer Overview Fazaclo Consumer Overview Compare FazaClo with other medications Borderline Personality DisorderParanoid DisorderSchizophrenia Where can I get more information? Your pharmacist can provide more information about clozapine.

See also: FazaClo side effects (in more detail)

naproxen

na-PROX-en

Oral route(Tablet;Tablet, Enteric Coated;Suspension)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Naproxen is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal .

Commonly used brand name(s)

In the U.S.

Aflaxen Aleve Aleve Arthritis Anaprox Anaprox DS EC Naprosyn Naprelan Naprelan 500 Naprelan Dose Card Naprosyn

In Canada

Naxen

Available Dosage Forms:

Tablet Suspension Tablet, Enteric Coated Tablet, Extended Release

Therapeutic Class: Analgesic

Pharmacologic Class: NSAID

Chemical Class: Propionic Acid (class)

Uses For naproxen

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis) such as inflammation, swelling, stiffness, and joint pain. Naproxen also helps relieve symptoms of ankylosing spondylitis, which is a type of arthritis that affects the joints in the spine. However, naproxen does not cure arthritis and will help you only as long as you continue to take it.

naproxen may also be used to treat mild to moderate pain, including acute gout and other painful conditions such as bursitis, tendonitis, or menstrual cramps.

naproxen is available only with your doctor's prescription.

Before Using naproxen

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For naproxen, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to naproxen or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of naproxen controlled-release tablets in the pediatric population. Safety and efficacy have not been established.

Appropriate studies have not been performed on the relationship of age to the effects of naproxen delayed release tablets, suspension, and tablets in children younger than 2 years of age. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of naproxen in the elderly. However, elderly patients may be more sensitive to the effects of naproxen than younger adults, and are more likely to have age-related kidney or stomach problems, which may require caution and an adjustment in the dose for patients receiving naproxen.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking naproxen, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using naproxen with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Ketorolac Pentoxifylline

Using naproxen with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abciximab Ardeparin Argatroban Aspirin Beclamide Beta Glucan Bivalirudin Caramiphen Carbamazepine Certoparin Chlormethiazole Cilostazol Citalopram Clopidogrel Clovoxamine Dabigatran Etexilate Dalteparin Danaparoid Desirudin Diazepam Dipyridamole Enoxaparin Escitalopram Ethotoin Felbamate Femoxetine Flesinoxan Fluoxetine Fluvoxamine Fondaparinux Fosphenytoin Gabapentin Ginkgo Heparin Lacosamide Lepirudin Mephenytoin Mephobarbital Methotrexate Nadroparin Nefazodone Oxcarbazepine Paraldehyde Paramethadione Parnaparin Paroxetine Pemetrexed Phenacemide Phenobarbital Phenytoin Piracetam Pregabalin Protein C Reviparin Rivaroxaban Rufinamide Sertraline Sibutramine Stiripentol Tacrolimus Tiagabine Ticlopidine Tinzaparin Tirofiban Topiramate Trimethadione Valproic Acid Vigabatrin Vilazodone Warfarin Zimeldine Zonisamide

Using naproxen with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acebutolol Acetohexamide Alacepril Alprenolol Amiloride Arotinolol Atenolol Azilsartan Medoxomil Azosemide Befunolol Bemetizide Benazepril Bendroflumethiazide Benzthiazide Betaxolol Bevantolol Bisoprolol Bopindolol Bucindolol Bumetanide Bupranolol Buthiazide Candesartan Cilexetil Canrenoate Captopril Carteolol Carvedilol Celiprolol Chlorothiazide Chlorpropamide Chlorthalidone Cilazapril Clopamide Cyclopenthiazide Cyclosporine Delapril Desvenlafaxine Dilevalol Duloxetine Enalaprilat Enalapril Maleate Eprosartan Esmolol Ethacrynic Acid Fosinopril Furosemide Gliclazide Glimepiride Glipizide Gliquidone Glyburide Hydrochlorothiazide Hydroflumethiazide Imidapril Indapamide Irbesartan Labetalol Landiolol Levobetaxolol Levobunolol Lisinopril Lithium Losartan Mepindolol Methyclothiazide Metipranolol Metolazone Metoprolol Milnacipran Moexipril Nadolol Nebivolol Nipradilol Olmesartan Medoxomil Oxprenolol Penbutolol Pentopril Perindopril Pindolol Piretanide Polythiazide Propranolol Quinapril Ramipril Sotalol Spirapril Spironolactone Talinolol Tasosartan Telmisartan Temocapril Tertatolol Timolol Tolazamide Tolbutamide Torsemide Trandolapril Triamterene Trichlormethiazide Valsartan Venlafaxine Xipamide Zofenopril Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of naproxen. Make sure you tell your doctor if you have any other medical problems, especially:

Anemia or Bleeding problems or Blood clots or Edema (fluid retention or body swelling) or Heart attack, history of or Heart disease (e.g., congestive heart failure) or Hypertension (high blood pressure) or Kidney disease or Liver disease (e.g., hepatitis) or Stomach or intestinal ulcers or bleeding, history of or Stroke, history of—Use with caution. May make these conditions worse. Aspirin-sensitive asthma or Aspirin sensitivity, history of—Should not be used in patients with these conditions. Heart surgery (e.g., coronary artery bypass graft [CABG])—Should not be used to relieve pain right before or after the surgery. Proper Use of naproxen

For safe and effective use of naproxen, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of naproxen may increase the chance of unwanted effects, especially in elderly patients.

naproxen should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

When used for severe or continuing arthritis, naproxen must be taken regularly as ordered by your doctor in order for it to help you. naproxen usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of naproxen.

Check with your doctor first before changing dosage forms (e.g., tablets, suspension). These forms are very different from each other.

Swallow the delayed-release tablet whole. Do not crush, break, or chew it.

If you are using the suspension, shake it gently before using it. Use the marked measuring cup included in the package to measure the dose.

Dosing

The dose of naproxen will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of naproxen. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For naproxen (e.g., Naprosyn®) tablet and oral suspension dosage forms: For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: Adults—At first, 250 milligrams (mg) (10 milliliters (mL)/2 teaspoonfuls), 375 mg (15 mL/3 teaspoonfuls), or 500 mg (20 mL/4 teaspoonfuls) two times a day, in the morning and evening. Your doctor may increase your dose, as needed, up to a total of 1500 mg per day. Children 2 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 5 milligrams (mg) per kilogram (kg) of body weight two times a day. Children younger than 2 years of age—Use and dose must be determined by your doctor. For bursitis, tendonitis, menstrual cramps, and other kinds of pain: Adults—500 milligrams (mg) for the first dose, then 250 mg every 6 to 8 hours as needed. Children—Use and dose must be determined by your doctor. For acute gout: Adults—750 milligrams (mg) for the first dose, then 250 mg every 8 hours until the attack is relieved. Children—Use and dose must be determined by your doctor. For naproxen controlled-release tablet (e.g., Naprelan®) dosage form: For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: Adults—At first, 750 milligrams (mg) (taken as one 750 mg or two 375 mg tablets) or 1000 mg (taken as two 500 mg tablets) once a day. Your doctor may adjust your dose as needed, up to a total of 1500 mg (taken as two 750 mg or three 500 mg tablets) per day. Children—Use and dose must be determined by your doctor. For bursitis, tendonitis, menstrual cramps, and other kinds of pain: Adults—At first, 1000 milligrams (mg) (taken as two 500 mg tablets) once a day. Some patients may need 1500 mg (taken as two 750 mg or three 500 mg tablets) per day, for a limited period. However, the dose is usually not more than 1000 mg per day. Children—Use and dose must be determined by your doctor. For acute gout: Adults—1000 to 1500 milligrams (mg) (taken as two to three 500 mg tablets) once a day for the first dose, then 1000 mg (taken as two 500 mg tablets) once a day until the attack is relieved. Children—Use and dose must be determined by your doctor. For naproxen delayed-release tablet (e.g., EC-Naprosyn®) dosage form: For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: Adults—At first, 375 or 500 milligrams (mg) two times a day, in the morning and evening. Your doctor may increase the dose, if necessary, up to a total of 1500 mg per day. Children—Use and dose must be determined by your doctor. For naproxen sodium (e.g., Anaprox®, Anaprox® DS) tablet dosage form: For rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: Adults—At first, 275 or 550 milligrams (mg) two times a day, in the morning and evening. Your doctor may increase the dose, if necessary, up to a total of 1500 mg per day. Children—Use and dose must be determined by your doctor. For bursitis, tendonitis, menstrual cramps, and other kinds of pain: Adults—550 milligrams (mg) for the first dose, then 550 mg every 12 hours or 275 mg every 6 to 8 hours as needed. Your doctor may increase the dose, if necessary, up to a total of 1375 mg per day. Children—Use and dose must be determined by your doctor. For acute gout: Adults—825 milligrams (mg) for the first dose, then 275 mg every 8 hours until the attack is relieved. Children—Use and dose must be determined by your doctor. Missed Dose

If you miss a dose of naproxen, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using naproxen

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects.

naproxen may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use naproxen for a long time might also have a higher risk.

naproxen may cause bleeding in your stomach or intestines. This problem can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years of age, are in poor health, or are using certain other medicines (such as a steroid or a blood thinner).

Serious skin reactions can occur during treatment with naproxen. Check with your doctor right away if you have any of the following symptoms while taking naproxen: blistering, peeling, or loosening of the skin; chills; cough; diarrhea; fever; itching; joint or muscle pain; red skin lesions; sore throat; sores, ulcers, or white spots in the mouth or on the lips; or unusual tiredness or weakness.

Possible warning signs of some serious side effects that can occur during treatment with naproxen may include swelling of the face, fingers, feet, or lower legs; severe stomach pain, black, tarry stools, or vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; unusual bleeding or bruising; or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in the chest, fast or irregular heartbeat, unusual flushing or warmth of the skin, weakness, or slurring of speech. Stop taking naproxen and check with your doctor immediately if you notice any of these warning signs.

naproxen may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur more often in patients who are allergic to aspirin or to any of the nonsteroidal anti-inflammatory drugs. Anaphylaxis can be life-threatening and requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once.

Using naproxen during late pregnancy can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

Check with your doctor immediately if blurred vision, difficulty with reading, or any other change in vision occurs during or after your treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Before having any kind of surgery or medical tests, tell your doctor that you are taking naproxen. It may be necessary for you to stop treatment for a while, or to change to a different nonsteroidal anti-inflammatory drug before your procedure.

naproxen may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to naproxen before you drive, use machines, or do anything else that could be dangerous if you are not alert. .

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

naproxen Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common Belching bruising difficult or labored breathing feeling of indigestion headache itching skin large, flat, blue, or purplish patches in the skin pain in the chest below the breastbone shortness of breath skin eruptions stomach pain swelling tightness in the chest wheezing Less common Bloating bloody or black, tarry stools blurred or loss of vision burning upper abdominal or stomach pain cloudy urine constipation decrease in urine output or decrease in urine-concentrating ability disturbed color perception double vision fast, irregular, pounding, or racing heartbeat or pulse halos around lights indigestion loss of appetite nausea or vomiting night blindness overbright appearance of lights pale skin pinpoint red or purple spots on the skin severe and continuing nausea severe stomach burning, cramping, or pain skin rash swelling or inflammation of the mouth troubled breathing with exertion tunnel vision unusual bleeding or bruising unusual tiredness or weakness vomiting of material that looks like coffee grounds weight loss Rare Anxiety back or leg pains bleeding gums blindness blistering, peeling, or loosening of the skin blood in the urine or stools blue lips and fingernails canker sores change in the ability to see colors, especially blue or yellow chest pain or discomfort clay-colored stools cold sweats coma confusion cool, pale skin cough or hoarseness coughing that sometimes produces a pink frothy sputum cracks in the skin darkened urine decreased vision depression diarrhea difficult, burning, or painful urination difficult, fast, or noisy breathing difficulty with swallowing dilated neck veins dizziness dry cough dry mouth early appearance of redness, or swelling of the skin excess air or gas in the stomach extreme fatigue eye pain fainting fever with or without chills fluid-filled skin blisters flushed, dry skin frequent urination fruit-like breath odor greatly decreased frequency of urination or amount of urine hair loss high fever hives increased hunger increased sensitivity of the skin to sunlight increased sweating increased thirst increased urination increased volume of pale, dilute urine irregular breathing joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs late appearance of rash with or without weeping blisters that become crusted, especially in sun-exposed areas of skin, may extend to unexposed areas light-colored stools lightheadedness loss of heat from the body lower back or side pain nervousness nightmares no blood pressure no breathing no pulse nosebleeds numbness or tingling in the hands, feet, or lips pain in the ankles or knees pain or burning in the throat pain or discomfort in the arms, jaw, back, or neck painful, red lumps under the skin, mostly on the legs pains in the stomach, side, or abdomen, possibly radiating to the back pale or blue lips, fingernails, or skin pounding in the ears puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue rapid, shallow breathing red, irritated eyes red skin lesions, often with a purple center red-green color blindness redness or other discoloration of the skin redness, swelling, or soreness of the tongue scaly skin seizures severe sunburn shakiness skin thinness slurred speech sneezing sore throat sores, ulcers, or white spots on the lips or tongue or inside the mouth sores, welting, or blisters spots on your skin resembling a blister or pimple stiff neck or back stomach cramps or tenderness stomach upset swelling in the legs and ankles swelling of the face, fingers, feet, or lower legs swollen, painful, or tender lymph glands in the neck, armpit, or groin tiny bumps on the inner lining of the eyelid unexplained weight loss unpleasant breath odor watery or bloody diarrhea weakness or heaviness of the legs weight gain yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose Bleeding under the skin confusion about identity, place, and time muscle tremors restlessness sleepiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Continuing ringing or buzzing or other unexplained noise in the ears hearing loss Less common Acid or sour stomach change in hearing feeling of constant movement of self or surroundings passing gas sensation of spinning stomach soreness or discomfort Rare Appetite changes burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings burning, dry, or itching eyes difficulty with moving discharge, excessive tearing general feeling of discomfort or illness lack or loss of strength menstrual changes muscle aching, cramping, stiffness, or weakness not able to concentrate redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid seeing, hearing, or feeling things that are not there shakiness in the legs, arms, hands, or feet sleeplessness swollen joints trembling or shaking of the hands or feet trouble getting pregnant trouble performing routine tasks trouble sleeping unable to sleep unusual drowsiness, dullness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: naproxen side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More naproxen resources Naproxen Side Effects (in more detail)Naproxen Use in Pregnancy & BreastfeedingDrug ImagesNaproxen Drug InteractionsNaproxen Support Group131 Reviews for Naproxen - Add your own review/rating Naproxen Professional Patient Advice (Wolters Kluwer) Naproxen Prescribing Information (FDA) Naproxen Monograph (AHFS DI) Naproxen MedFacts Consumer Leaflet (Wolters Kluwer) Aleve Consumer Overview Anaprox MedFacts Consumer Leaflet (Wolters Kluwer) EC-Naprosyn Enteric-Coated Tablets MedFacts Consumer Leaflet (Wolters Kluwer) Naprosyn Consumer Overview Naprosyn Prescribing Information (FDA) Compare naproxen with other medications Ankylosing SpondylitisAseptic NecrosisBack PainBursitisCostochondritisDiffuse Idiopathic Skeletal HyperostosisDysautonomiaFeverFrozen ShoulderGout, AcuteHeadacheJuvenile Rheumatoid ArthritisMuscle PainOsteoarthritisPainPeriod PainRheumatoid ArthritisSciaticaSpondylolisthesisTendonitis

J-COF DHC Liquid
Pronunciation: SOO-doe-e-FED-rin/BROME-fen-IR-a-meen/dye-HYE-droe-KOE-deenGeneric Name: Pseudoephedrine/Brompheniramine/DihydrocodeineBrand Name: J-COF DHC

Cancidas
Pronunciation: KAS-poe-FUN-jinGeneric Name: CaspofunginBrand Name: Cancidas

atovaquone

a-TOE-va-kwone

Commonly used brand name(s)

In the U.S.

Mepron

Available Dosage Forms:

Tablet Suspension

Therapeutic Class: Antiprotozoal

Chemical Class: Ubiquinone

Uses For atovaquone

Atovaquone is used to treat and to prevent Pneumocystis carinii pneumonia (PCP), a very serious kind of pneumonia. This particular kind of pneumonia occurs commonly in patients whose immune systems are not working normally, such as cancer patients, transplant patients, and patients with acquired immune deficiency syndrome (AIDS).

atovaquone is available only with your doctor's prescription.

Before Using atovaquone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For atovaquone, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to atovaquone or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of atovaquone in children 1 month to 13 years of age. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of atovaquone in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems which may require an adjustment of dosage in patients receiving atovaquone .

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking atovaquone, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using atovaquone with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Rifampin

Using atovaquone with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Indinavir Rifabutin Tetracycline Warfarin Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of atovaquone. Make sure you tell your doctor if you have any other medical problems, especially:

Liver disease, severe or Stomach or intestinal disorders—Atovaquone may not work properly in patients with these conditions . Proper Use of atovaquone

Make certain your doctor knows if you are on any special diet. atovaquone must be taken with balanced meals so that it can work properly.

It is important that you take atovaquone with a balanced meal. This is to make sure the medicine is fully absorbed into the body and will work properly.

Atovaquone tablets may be crushed if necessary to make it easier to swallow.

Because atovaquone tablets and oral suspension do not produce the same amount of medicine in the blood, the tablets and the suspension cannot be switched and used in place of each other.

For patients taking the oral liquid form of atovaquone:

Shake the bottle gently before using atovaquone. atovaquone is to be taken by mouth. Use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid. Do not use after the expiration date on the label since the medicine may not work properly after that date. Check with your pharmacist if you have any questions about this .

To help clear up your infection completely, keep taking your medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop taking atovaquone too soon, your symptoms may return.

Atovaquone works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses.

Dosing

The dose of atovaquone will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of atovaquone. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For prevention of Pneumocystis carinii pneumonia (PCP): For oral dosage form (suspension): Adults and teenagers—1,500 milligrams (mg) or 10 milliliters (mL) once a day with a meal. Children—Use and dose must be determined by your doctor . For treatment of Pneumocystis carinii pneumonia (PCP): For oral dosage form (suspension): Adults and teenagers—750 milligrams (mg) or 5 milliliters (mL) taken with a meal two times a day for 21 days. Children—Use and dose must be determined by your doctor . For oral dosage form (tablets): Adults and teenagers—750 milligrams (mg) taken with a meal three times a day for 21 days. Children—Use and dose must be determined by your doctor. Missed Dose

If you miss a dose of atovaquone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using atovaquone

It is very important that your doctor check your progress at regular visits to make sure that atovaquone is working properly. Blood tests may be needed to check for unwanted effects .

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

atovaquone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common Cough or hoarseness difficult or labored breathing fever or chills lower back or side pain painful or difficult urination shortness of breath tightness in chest wheezing Incidence not known Black, tarry stools bleeding gums bloating blood in urine or stools bluish-colored lips, fingernails, or palms constipation dark urine dizziness or lightheadedness fast heartbeat headache indigestion large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs light-colored stools loss of appetite nausea noisy breathing pains in stomach, side, or abdomen, possibly radiating to the back pale skin pinpoint red spots on skin rapid heart rate sore throat unusual bleeding or bruising unusual tiredness or weakness vomiting yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Abdominal or stomach pain diarrhea lack or loss of strength runny nose skin rash sleeplessness sneezing sore mouth or tongue stuffy nose sweating trouble in sleeping unable to sleep white patches in mouth, tongue, or throat Incidence not known Blistering, peeling, or loosening of skin eye irritation or redness itching joint or muscle pain red skin lesions, often with a purple center skin rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: atovaquone side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More atovaquone resources Atovaquone Side Effects (in more detail)Atovaquone Use in Pregnancy & BreastfeedingAtovaquone Drug InteractionsAtovaquone Support Group1 Review for Atovaquone - Add your own review/rating atovaquone Concise Consumer Information (Cerner Multum) Atovaquone MedFacts Consumer Leaflet (Wolters Kluwer) Atovaquone Monograph (AHFS DI) Atovaquone Professional Patient Advice (Wolters Kluwer) Atovaquone and Proguanil Hydrochloride Monograph (AHFS DI) Mepron Prescribing Information (FDA) Compare atovaquone with other medications BabesiosisMalariaPneumocystis PneumoniaPneumocystis Pneumonia ProphylaxisToxoplasmosis

Ictammolo Ramini

Ictammolo Ramini may be available in the countries listed below.

Ingredient matches for Ictammolo Ramini Ichthammol

Ichthammol is reported as an ingredient of Ictammolo Ramini in the following countries:

Italy

International Drug Name Search

tamsulosin

Generic Name: tamsulosin (tam soo LOE sin) Brand Names: Flomax

What is tamsulosin?

Tamsulosin is in a group of drugs called alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. Tamsulosin relaxes the muscles in the prostate and bladder neck, making it easier to urinate.

Tamsulosin is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate).

Tamsulosin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about tamsulosin? You should not use this medication if you are allergic to tamsulosin. Do not take tamsulosin with other similar medicines such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), or terazosin (Hytrin). Tamsulosin may cause dizziness or fainting, especially when you first start taking it or when you start taking it again. Be careful if you drive or do anything that requires you to be alert. Avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. If you stop taking tamsulosin for any reason, call your doctor before you start taking it again. You may need a dose adjustment.

Tamsulosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using tamsulosin before surgery unless your surgeon tells you to.

There are many other drugs that can interact with tamsulosin. Tell your doctor about all medications you use. What should I discuss with my healthcare provider before taking tamsulosin? You should not use this medication if you are allergic to tamsulosin. Do not take tamsulosin with other similar medicines such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), or terazosin (Hytrin).

If you have a history of prostate cancer, you may need a dose adjustment or special tests to safely take this tamsulosin.

Tamsulosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using tamsulosin before surgery unless your surgeon tells you to.

Although this medication is not for use in women, tamsulosin is not expected to harm an unborn baby. If you are a woman using this medication, tell your doctor if you are pregnant or breast-feeding. Tamsulosin is not for use in children. How should I take tamsulosin?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Tamsulosin is usually taken once a day, approximately 30 minutes after a meal. Try to take this medication at the same time each day. Do not crush, chew, or open a tamsulosin capsule. Swallow it whole. Tamsulosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it, or when you start taking it again. Call your doctor if you have severe dizziness or feel like you might pass out.

You may feel very dizzy when you first wake up. Be careful when standing or sitting up from a lying position.

If you stop taking tamsulosin for any reason, call your doctor before you start taking it again. You may need a dose adjustment.

Your blood pressure and prostate will need to be checked often. Visit your doctor regularly.

Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Store at room temperature away from moisture and heat.

See also: Tamsulosin dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

If you miss your doses for several days in a row, contact your doctor before restarting the medication. You may need a lower dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme dizziness or fainting.

What should I avoid while taking tamsulosin? Tamsulosin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

To prevent dizziness, avoid standing for long periods of time or becoming overheated during exercise and in hot weather.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Drinking alcohol can increase certain side effects of tamsulosin. Tamsulosin side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using tamsulosin and call your doctor at once if you have any of these serious side effects:

feeling like you might pass out;

chest pain;

fever, chills, body aches, or flu symptoms; or

penis erection that is painful or lasts 4 hours or longer.

Less serious side effects may include:

mild dizziness;

weakness, drowsiness;

headache;

nausea, diarrhea;

back pain;

blurred vision;

dental problems;

sleep problems (insomnia);

abnormal ejaculation, decreased sex drive; or

runny nose, sore throat, cough.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Tamsulosin Dosing Information

Usual Adult Dose for Benign Prostatic Hyperplasia:

0.4 mg orally once daily one-half hour following the same meal each day

What other drugs will affect tamsulosin?

Tell your doctor about all other medications you use, especially:

cimetidine (Tagamet);

conivaptan (Vaprisol);

cyclosporine (Gengraf, Neoral, Sandimmune);

imatinib (Gleevec);

isoniazid (for treating tuberculosis);

methimazole (Tapazole);

pioglitazone (Actos);

ropinirole (Requip);

ticlopidine (Ticlid);

warfarin (Coumadin);

an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), metronidazole (Flagyl, Protostat), telithromycin (Ketek), or terbinafine (Lamisil);

an antidepressant such as citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Tofranil), nefazodone, paroxetine (Paxil), sertraline (Zoloft), or tranylcypromine (Parnate);

antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), or voriconazole (Vfend);

anti-malaria medication such as chloroquine (Arelan) or pyrimethamine (Daraprim), or quinine (Qualaquin);

erectile dysfunction medicine such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);

heart or blood pressure medication such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nicardipine (Cardene), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;

a heart rhythm medication such as amiodarone (Cordarone, Pacerone) or quinidine (Quin-G);

HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir); or

medicine to treat psychiatric disorders, such as aripiprazole (Abilify), chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), perphenazine (Trilafon), or thioridazine (Mellaril).

This list is not complete and there are many other drugs that can interact with tamsulosin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. More tamsulosin resources Tamsulosin Side Effects (in more detail)Tamsulosin DosageTamsulosin Use in Pregnancy & BreastfeedingDrug ImagesTamsulosin Drug InteractionsTamsulosin Support Group65 Reviews for Tamsulosin - Add your own review/rating tamsulosin Advanced Consumer (Micromedex) - Includes Dosage Information Tamsulosin MedFacts Consumer Leaflet (Wolters Kluwer) Tamsulosin Prescribing Information (FDA) Flomax Prescribing Information (FDA) Flomax Monograph (AHFS DI) Flomax Consumer Overview Compare tamsulosin with other medications Benign Prostatic HyperplasiaOveractive BladderUrinary Tract Stones Where can I get more information? Your pharmacist can provide more information about tamsulosin.

See also: tamsulosin side effects (in more detail)

Atrial Fibrillation Medications

Definition of Atrial Fibrillation:

A condition where there is disorganised electrical conduction in the atria, resulting in ineffective pumping of blood into the ventricle.

Acronym: AF

Drugs associated with Atrial Fibrillation

The following drugs and medications are in some way related to, or used in the treatment of Atrial Fibrillation. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

See sub-topics

Topics under Atrial FibrillationPrevention of Thromboembolism in Atrial Fibrillation (24 drugs) Learn more about Atrial Fibrillation

Medical Encyclopedia:

Atrial fibrillation/flutter

Harvard Health Guide:

Symptoms and treatment for Atrial Fibrillation Drug List:BreviblocCardizem-Cd-24-Hour-Sustained-Release-Beads-CapsulesCartia-Xt-24-Hour-Sustained-Release-Beads-CapsulesCoregCorvertDilacor-Xr-24-Hour-Sustained-Release-CapsulesDiltia-Xt-24-Hour-Sustained-Release-CapsulesDiltiazem-Hydrochloride-SrDiltiazem-Hydrochloride-XtLanoxicapsLopressorMetoprolol-Succinate-ErRythmolSotalol-Hydrochloride-AfTiazacXarelto

Epivir-HBV Solution
Pronunciation: la-MIH-vyoo-deenGeneric Name: LamivudineBrand Name: Epivir-HBV

travoprost ophthalmic

Generic Name: travoprost ophthalmic (TRA voe prost off THAL mik) Brand Names: Travatan, Travatan Z

What is travoprost ophthalmic?

Travoprost ophthalmic (for the eye) reduces pressure in the eye by increasing the amount of fluid that drains from the eye.

Travoprost ophthalmic is used to treat certain types of glaucoma and other causes of high pressure inside the eye.

Travoprost ophthalmic may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about travoprost ophthalmic?

Travoprost ophthalmic may cause a gradual change in the color of your eyes or eyelids and lashes, as well as increased growth or thickness of your eyelashes. These color changes, usually an increase in brown pigment, occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.

Do not allow the dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

After using this medication, wait at least 5 minutes before using any other eye drops that your doctor has prescribed.

What should I discuss with my health care provider before using travoprost ophthalmic? Do not use this medication if you are allergic to travoprost.

Before using travoprost, tell your doctor if you are allergic to any drugs, or if you have swelling or infection of your eye.

Travoprost ophthalmic may cause a gradual change in the color of your eyes or eyelids and lashes, as well as increased growth or thickness of your eyelashes. These color changes, usually an increase in brown pigment, occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.

FDA pregnancy category C. It is not known whether travoprost is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether travoprost passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I use travoprost ophthalmic?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Wash your hands before using the eye drops.

To apply the eye drops:

Tilt your head back slightly and pull down on the lower eyelid to create a small pocket. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper. Squeeze out a drop and close your eye. Gently press your finger to the inside corner of the eye (near the nose) for about 1 minute to keep the liquid from draining into your tear duct.

If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop. Also wait at least 5 minutes before using any other eye drops that your doctor has prescribed.

Do not allow the dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye. At any time during your use of travoprost ophthalmic, tell your doctor at once if you have an eye injury, if you develop an eye infection, or if you plan to have eye surgery. Do not use the eye drops if the liquid changes colors or has particles in it. Store the drops at room temperature away from heat and moisture. Keep the bottle tightly closed when not in use. What happens if I miss a dose?

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of travoprost ophthalmic used in the eyes is not expected to produce life-threatening symptoms.

What should I avoid while using travoprost ophthalmic? Avoid using too much of this medication, which can actually make it less effective in lowering the pressure inside the eye.

Avoid using any eyedrop medicine that has not been prescribed by your doctor.

Travoprost ophthalmic side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using travoprost ophthalmic and call your doctor at once if you have any of these serious side effects:

redness, swelling, itching, or pain in or around your eye;

oozing or discharge from your eye;

increased sensitivity to light;

vision changes; or

chest pain.

Less serious side effects may include:

mild eye discomfort;

headache;

feeling like something is in your eye;

blurred vision;

dry or watery eyes; or

stinging or burning of the eyes after using the drops.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Travoprost ophthalmic Dosing Information

Usual Adult Dose for Intraocular Hypertension:

Instill 1 drop in the affected eye(s) once daily in the evening.

Usual Adult Dose for Glaucoma (Open Angle):

Instill 1 drop in the affected eye(s) once daily in the evening.

Usual Pediatric Dose for Intraocular Hypertension:

16 years and older:Instill 1 drop in the affected eye(s) once daily in the evening.

Usual Pediatric Dose for Glaucoma (Open Angle):

16 years and older:

Plexion Cleanser

Generic Name: sulfacetamide sodium and sulfur topical (SUL fa SEET a mide SOE dee um and SUL fur TOP i kal) Brand Names: Avar Cleanser, Avar Gel, Avar LS Cleanser, Avar-E, Avar-E Emollient, Avar-E Green, Avar-e LS, BP 10-Wash, Clarifoam EF, Clenia Emollient Cream, Clenia Foaming Wash, Plexion , Plexion Cleanser, Plexion Cleansing Cloths, Plexion SCT, Prascion, Prascion Cleanser, Prascion FC Cloths, Prascion RA, Rosac, Rosac Wash, Rosaderm Cleanser, Rosanil Cleanser, Rosula, SE 10-5 SS, Sulfacet-R, Sulfatol C, Sulfatol SS, SulZee Wash, Sumaxin, Sumaxin TS, Sumaxin Wash, Suphera, Topisulf, Zencia Wash, Zetacet

What is Plexion Cleanser (sulfacetamide sodium and sulfur topical)?

Sulfacetamide sodium and sulfur are antibiotic that fight bacteria.

The combination of sulfacetamide sodium and sulfur topical (for the skin) is used to treat acne, rosacea, and seborrheic dermatitis (a red, flaking skin rash).

Sulfacetamide sodium and sulfur topical may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Plexion Cleanser (sulfacetamide sodium and sulfur topical)? You should not use this medication if you are allergy to sulfa drugs or if you have kidney disease. Avoid getting this medication in your eyes, nose, or mouth. If this does happen, rinse with water.

Do not cover the treated skin area unless your doctor has told you to.

Avoid using other medications on the areas you treat with sulfacetamide sodium and sulfur topical unless you doctor tells you to. What should I discuss with my healthcare provider before using Plexion Cleanser (sulfacetamide sodium and sulfur topical)? You should not use this medication if you are allergy to sulfa drugs or if you have kidney disease.

To make sure you can safely use this medication, tell your doctor about all of your medical conditions.

FDA pregnancy category C. It is not known whether sulfacetamide sodium and sulfur topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether sulfacetamide sodium and sulfur topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I use Plexion Cleanser (sulfacetamide sodium and sulfur topical)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Wash your hands before and after applying this medication.

Do not cover the treated skin area unless your doctor has told you to.

Use this medication regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Store at room temperature away from moisture and heat. What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Plexion Cleanser (sulfacetamide sodium and sulfur topical)? Avoid getting this medication in your eyes, nose, or mouth. If this does happen, rinse with water. Do not use sulfacetamide sodium and sulfur topical on sunburned, windburned, dry, chapped, irritated, or broken skin.

Avoid using other medications on the areas you treat with sulfacetamide sodium and sulfur topical unless you doctor tells you to.

Plexion Cleanser (sulfacetamide sodium and sulfur topical) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

new or worsening skin rash;

joint pain;

fever; or

mouth sores.

Less serious side effects may include redness, warmth, swelling, itching, stinging, burning, or irritation of treated skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Plexion Cleanser (sulfacetamide sodium and sulfur topical)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied sulfacetamide sodium and sulfur. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Plexion Cleanser resources Plexion Cleanser Use in Pregnancy & BreastfeedingPlexion Cleanser Drug InteractionsPlexion Cleanser Support Group0 Reviews for Plexion - Add your own review/rating Avar LS Cleanser MedFacts Consumer Leaflet (Wolters Kluwer) Clarifoam EF Foam MedFacts Consumer Leaflet (Wolters Kluwer) Clarifoam EF Prescribing Information (FDA) Plexion Prescribing Information (FDA) Plexion Cleansing Cloths MedFacts Consumer Leaflet (Wolters Kluwer) Plexion SCT Cream MedFacts Consumer Leaflet (Wolters Kluwer) Plexion TS Emulsion MedFacts Consumer Leaflet (Wolters Kluwer) Prascion Cleanser Prescribing Information (FDA) Rosac Cream MedFacts Consumer Leaflet (Wolters Kluwer) Rosaderm Cleanser Prescribing Information (FDA) Rosanil Cleanser Prescribing Information (FDA) Rosula Foam MedFacts Consumer Leaflet (Wolters Kluwer) Rosula Prescribing Information (FDA) Rosula Cleanser Emulsion MedFacts Consumer Leaflet (Wolters Kluwer) Sumadan MedFacts Consumer Leaflet (Wolters Kluwer) Sumadan Wash Prescribing Information (FDA) Sumaxin Wash MedFacts Consumer Leaflet (Wolters Kluwer) Sumaxin Wash Prescribing Information (FDA) Zencia Wash Prescribing Information (FDA) Compare Plexion Cleanser with other medications AcneRosaceaSeborrheic Dermatitis Where can I get more information? Your pharmacist can provide more information about sulfacetamide sodium and sulfur topical.

Heparin (Mucous ) Injection BP (Leo Laboratories Ltd)
1. Name Of The Medicinal Product

HEPARIN (MUCOUS) INJECTION BP

2. Qualitative And Quantitative Composition

Heparin (Mucous) Injection BP 1000 Units/ml: each ml contains Heparin Sodium 1,000 IU

Heparin (Mucous) Injection BP 5000 Units/ml: each ml contains Heparin Sodium 5,000 IU

Heparin (Mucous) Injection BP 25000 Units/ml: each ml contains Heparin Sodium 25,000 IU

3. Pharmaceutical Form

Solution for Injection.

4. Clinical Particulars 4.1 Therapeutic Indications

For the treatment of thrombo-embolic disorders such as deep vein thrombosis, acute arterial embolism or thrombosis, thrombophlebitis, pulmonary embolism and fat embolism.

For prophylaxis against deep vein thrombosis and thrombo-embolic events in susceptible patients.

4.2 Posology And Method Of Administration

For intravenous or subcutaneous injection.

Treatment Dosage:

Intravenous administration

5,000 - 10,000 IU every 4 hours or 500 IU/kg bodyweight daily as a continuous infusion in sodium chloride injection or dextrose injection. Doses should be individually adjusted according to coagulation tests.

Subcutaneous administration

The initial dose is 250 IU/kg bodyweight. Further doses should be given every 12 hours and individually adjusted according to coagulation tests.

Dosage adjustment

It is recommended that dosages be adjusted to maintain a thrombin clotting time, whole blood clotting time or activated partial thromboplastin time 1.5 to 2 times that of control on blood withdrawn 4 - 6 hours after the first injection or commencement of infusion and at similar intervals until the patient is stabilised.

Prophylactic Dosage:

Administration is by subcutaneous injection.

Patients undergoing major elective surgery:

5,000 IU should be given 2 hours pre-operatively and then every 8 - 12 hours post-operatively for 10 - 14 days or until the patient is ambulant, whichever is the longer.

Following myocardial infarction:

5,000 IU should be given twice daily for 10 days or until the patient is mobile.

Other patients:

5,000 IU should be given every 8 - 12 hours.

These standard prophylactic regimens do not require routine control.

Dosage in Children

Treatment Dosage:

Standard treatment dosages should be given initially. Subsequent dosages and/or dosage intervals should be individually adjusted according to changes in thrombin clotting time, whole blood clotting time and/or activated partial thromboplastin time.

Dosage in the Elderly

Treatment Dosage:

Lower treatment dosages may be required. However, standard treatment dosages should be given initially and then subsequent dosages and/or dosage intervals should be individually adjusted according to changes in thrombin clotting time, whole blood clotting time and/or activated partial thromboplastin time.

Prophylactic Dosage:

Dosage alterations are unnecessary for prophylaxis in the elderly.

Pregnancy

This heparin formulation contains the preservative benzyl alcohol. As benzyl alcohol may cross the placenta the use of this formulation should be avoided in pregnancy. If use is considered essential, the dosage recommendations given in this section should be followed.

Treatment Dosage:

Standard treatment dosages should be given initially by continuous intravenous infusion, or every 12 hours by subcutaneous injection. Intermittent intravenous injections are not advised. Subsequent dosages and/or dosage intervals should be individually adjusted according to changes in thrombin clotting time, whole blood clotting time and/or activated partial thromboplastin time.

Prophylactic Dosage:

It is recommended that plasma heparin levels be maintained below 0.4 IU/ml as determined by specific anti-Xa assay. A suggested dosage is 5,000 IU every 12 hours in early pregnancy increasing to 10,000 IU every 12 hours in the last trimester. The dosage should be reduced during labour and the standard prophylactic dosage is suitable in the puerperium.

4.3 Contraindications

Known hypersensitivity to constituents.

Current or history of heparin-induced thrombocytopenia.

Generalised or local haemorrhagic tendency, including uncontrolled severe hypertension, severe liver insufficiency, active peptic ulcer, acute or subacute septic endocarditis, intracranial haemorrhage or injuries and operations on the central nervous system, eyes and ears, and in women with abortus imminens.

Heparin (Mucous) Injection contains 10 mg/ml of the preservative benzyl alcohol. This formulation must not be given to premature babies or neonates (see Section 4.6).

An epidural anaesthesia during birth in pregnant women treated with heparin is contraindicated (see Section 4.6).

In patients receiving heparin for treatment rather than prophylaxis, locoregional anaesthesia in elective surgical procedures is contra-indicated because the use of heparin may be very rarely associated with epidural or spinal haematoma resulting in prolonged or permanent paralysis.

4.4 Special Warnings And Precautions For Use

Heparin should be used with caution in patients with hypersensitivity to low molecular weight heparin.

Care should be taken when heparin is administered to patients with increased risk of bleeding complications, hypertension, renal or hepatic insufficiency.

Heparin can suppress adrenal secretion of aldosterone leading to hyperkalaemia, particularly in patients such as those with diabetes mellitus, chronic renal failure, pre-existing metabolic acidosis, a raised plasma potassium or taking potassium sparing drugs. The risk of hyperkalaemia appears to increase with duration of therapy but is usually reversible. Plasma potassium should be measured in patients at risk before starting heparin therapy and monitored regularly thereafter particularly if treatment is prolonged beyond about 7 days.

Drugs affecting platelet function or the coagulation system should in general not be given concomitantly with heparin (see Section 4.5).

In patients undergoing peridural or spinal anaesthesia or spinal puncture, the prophylactic use of heparin may be very rarely associated with epidural or spinal haematoma resulting in prolonged or permanent paralysis. The risk is increased by the use of a peridural or spinal catheter for anaesthesia, by the concomitant use of drugs affecting haemostasis such as non-steroidal anti-inflammatory drugs (NSAIDs), platelet inhibitors or anticoagulants, and by traumatic or repeated puncture.

In decision making on the interval between the last administration of heparin at prophylactic doses and the placement or removal of a peridural or spinal catheter, the product characteristics and the patient profile should be taken into account. Subsequent dose should not take place before at least four hours have elapsed. Re-administration should be delayed until the surgical procedure is completed.

Should a physician decide to administer anti-coagulation in the context of peridural or spinal anaesthesia, extreme vigilance and frequent monitoring must be exercised to detect any signs and symptoms of neurologic impairment, such as back pain, sensory and motor deficits and bowel or bladder dysfunction. Patients should be instructed to inform immediately a nurse or a clinician if they experience any of these.

Heparin should not be administered by intramuscular injection due to the risk of haematoma.

Due to increased bleeding risk, care should be taken when giving concomitant intramuscular injections, lumbar puncture and similar procedures.

As there is a risk of antibody-mediated heparin-induced thrombocytopenia, platelet counts should be measured in patients receiving heparin treatment for longer than 5 days and the treatment should be stopped immediately in those who develop thrombocytopenia.

Heparin induced thrombocytopenia and heparin induced thrombocytopenia with thrombosis can occur up to several weeks after discontinuation of heparin therapy. Patients presenting with thrombocytopenia or thrombosis after discontinuation of heparin should be evaluated for HIT and HITT.

Heparin (Mucous) Injection contains the preservative benzyl alcohol 10mg/ml. This product should be administered with caution to infants and children up to 3 years old, as there is a risk that benzyl alcohol may cause toxic reactions and allergic reactions (anaphylactoid) in this age group.

Heparin (Mucous) Injection contains esters of parahydroxybenzoates as a preservative system. These may cause allergic reactions (possibly delayed), and exceptionally, bronchospasm.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

The anticoagulant effect of heparin may be enhanced by concomitant medication with other drugs affecting platelet function or the coagulation system, e.g. platelet aggregation inhibitors, thrombolytic agents, salicylates, non-steroidal anti-inflammatory drugs, vitamin K antagonists, dextrans, activated protein C. Where such combination cannot be avoided, careful clinical and biological monitoring is required.

Combined use with ACE inhibitors or angiotensin II antagonists may increase the risk of hyperkalaemia.

Use of glyceryl trinitrate infusion may reduce the anticoagulant effect of heparin.

4.6 Pregnancy And Lactation

Because of the known haemorrhagic effect, heparin should be used with caution in pregnant women and only if the benefits outweigh the risks according to the physician's judgement. Precaution is particularly required because of uteroplacental haemorrhage, especially at the time of delivery. If epidural anaesthesia is envisaged, heparin treatment should be suspended, whenever possible.

Heparin (Mucous) Injection contains 10 mg/ml of the preservative benzyl alcohol. Cases of “Gasping Syndrome” have occurred in premature infants when large amounts of benzyl alcohol have been administered (99-404 mg/kg/day). Therefore the use of this formulation in newborns (especially in preterm babies) is contraindicated (see Section 4.3).

As benzyl alcohol may cross the placenta, the use of this formulation should be avoided during pregnancy.

The use of heparin in women with abortus imminens is contraindicated (see Section 4.3).

Heparin does not cross the placental barrier and is not excreted in breast milk.

4.7 Effects On Ability To Drive And Use Machines

Heparin has no or negligible influence on the ability to drive or use machines.

4.8 Undesirable Effects

Very common

>1/10

Common

>1/100 and <1/10

Uncommon

>1/1,000 and <1/100

Rare

>1/10,000 and <1/1,000

Very rare

<1/10,000

The most frequently reported undesirable effects are bleeding events, reversible increase in liver enzymes, reversible thrombocytopenia and various skin reactions. Isolated reports of generalised allergic reactions, skin necrosis and priapism have been reported.

•Blood and lymphatic system disorders

Heparin can cause thrombocytopenia either through a direct effect or through an immune effect producing a platelet-aggregating antibody (see Section 4.4). Reversible after drug withdrawal.

Common:

Thrombocytopenia type I

Rare:

Thrombocytopenia type II, probably of an immunoallergic nature (see section 4.4)

In some cases thrombocytopenia type II has been accompanied by venous or arterial thrombi.

•Immune system disorders

Rare:

Allergic reactions of all types and severities, with various manifestations

Very rare:

Anaphylactoid reactions and anaphylactic shock

•Metabolism and nutrition disorders

Rare:

Hypoaldosteronism. Heparin products can cause hypoaldosteronism which may result in an increase in plasma potassium. Rarely, clinically significant hyperkalaemia may occur particularly in patients with chronic renal failure and diabetes mellitus (see Section 4.4).

•Vascular disorders

Common:

Haemorrhage

Haemorrhages may affect any organ, particularly inconnection with high doses.

In some cases haemorrhage has resulted in death or permanent disability.

Very rare cases of epidural and spinal haematoma have been reported in patients receiving heparin for prophylaxis undergoing spinal or epidural anaesthesia or spinal puncture (see Section 4.4).

•Hepatobiliary disorders

Common:

Raised transaminases, gamma-GT, LDH and lipase levels. They are reversible after drug withdrawal.

•Skin and subcutaneous tissue disorder

Uncommon:

Rash (various types of rash such as erythematous and maculopapular), urticaria, pruritus.

Rare:

Skin necrosis. If this occurs treatment must be withdrawn immediately.

One case of erythema multiforme was also reported.

•Musculoskeletal and connective tissue disorders

Uncommon:

Osteoporosis has been reported in connection with long-term heparin treatment.

•Reproductive system and breast disorders

Very rare:

Priapism

•General disorders and administration site conditions

Common:

Injection site reactions; local irritation may occur when injected subcutaneously

4.9 Overdose

Bleeding is the main sign of overdose with heparin. As heparin is eliminated quickly, a discontinuation of treatment is sufficient in case of minor haemorrhages. In case of severe haemorrhages heparin may be neutralised with protamine sulphate injected slowly intravenously. One mg of protamine sulphate neutralises approximately 100 IU of heparin. Nevertheless, the required protamine sulphate dose varies according to the time of heparin administration and the dose administered.

It is important to avoid overdosage of protamine sulphate because protamine itself has anticoagulant properties. A single dose of protamine sulphate should never exceed 50 mg. Intravenous injection of protamine may cause a sudden fall in blood pressure, bradycardia, dyspnoea and transitory flushing, but these may be avoided or diminished by slow and careful administration.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Heparin is a naturally occurring anticoagulant which prevents the coagulation of blood in-vivo and in-vitro. It potentiates the inhibition of several activated coagulation factors, including thrombin and factor X.

5.2 Pharmacokinetic Properties

The increase in clotting time provided by heparin becomes apparent immediately after administration and lasts for four to six hours after intravenous injection and for about eight hours after subcutaneous injection.

5.3 Preclinical Safety Data

There are no preclinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Heparin (Mucous) Injection BP 1000 Units/ml and Heparin (Mucous) Injection BP 5000 Units/ml: Benzyl alcohol, Methyl parahydroxybenzoate, Propyl parahydroxybenzoate, Sodium citrate dihydrate, Sodium chloride and Water for Injections.

Heparin (Mucous) Injection BP 25000 Units/ml: Benzyl alcohol, Methyl parahydroxybenzoate, Propyl parahydroxybenzoate, Sodium citrate dihydrate and Water for Injections.

6.2 Incompatibilities

Heparin has been reported to be incompatible in aqueous solution with certain substances, e.g. some antibiotics, hydrocortisone, phenothiazines, narcotic analgesics and some antihistamines.

6.3 Shelf Life

3 years.

6.4 Special Precautions For Storage

Store below 25°C.

6.5 Nature And Contents Of Container

Heparin (Mucous) Injection BP 1000 Units/ml: 10 x 5 ml vials.

Heparin (Mucous) Injection BP 5000 Units/ml: 10 x 5ml vials.

Heparin (Mucous) Injection BP 25000 Units/ml: 5 x 5ml vials.

6.6 Special Precautions For Disposal And Other Handling

From a microbiological point of view, once opened, the product may be stored for a maximum of 14 days below 25°C. Other in use storage times and conditions are the responsibility of the user.

7. Marketing Authorisation Holder

LEO Laboratories Limited

Longwick Road

Princes Risborough

Bucks HP27 9RR

8. Marketing Authorisation Number(S)

Heparin (Mucous) Injection BP 1000 Units/ml - PL 0043/0041R.

Heparin (Mucous) Injection BP 5000 Units/ml - PL 0043/0038R

Heparin (Mucous) Injection BP 25000 Units/ml - PL 0043/0039R.

9. Date Of First Authorisation/Renewal Of The Authorisation

Heparin (Mucous) Injection BP 1000 Units/ml - 3 December 1975.

Heparin (Mucous) Injection BP 5000 Units/ml and Heparin (Mucous)

Injection BP 25000 Units/ml - 4 December 1975.

10. Date Of Revision Of The Text

April 2007

LEGAL CATEGORY

POM

Talacen
Pronunciation: a-SEET-a-MIN-oh-fen/pen-TAZ-oh-seenGeneric Name: Acetaminophen/PentazocineBrand Name: Generic only. No brands available.

Catapres-TTS Patches
Pronunciation: KLOE-ni-deenGeneric Name: ClonidineBrand Name: Catapres-TTS

Maxzide

Generic Name: hydrochlorothiazide and triamterene (HYE dro klor oh THY a zide and trye AM ter een) Brand Names: Dyazide, Maxzide, Maxzide-25

What is Maxzide (hydrochlorothiazide and triamterene)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Triamterene is a potassium-sparing diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

The combination of hydrochlorothiazide and triamterene is used to treat fluid retention (edema) and high blood pressure (hypertension).

Hydrochlorothiazide and triamterene may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Maxzide (hydrochlorothiazide and triamterene)? You should not use this medication if you are allergic to hydrochlorothiazide or triamterene, or if you have kidney disease, urination problems, high levels of potassium in your blood, or if you are taking other diuretics similar to triamterene. Do not use potassium supplements unless your doctor has told you to.

Before using this medication, tell your doctor if you have heart or liver disease, glaucoma, diabetes, a breathing disorder, gout, lupus, kidney stones, a pancreas disorder, or an allergy to sulfa drugs or penicillin.

Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and triamterene.

Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.

Do not use potassium supplements, salt substitutes, or low-sodium milk while you are taking hydrochlorothiazide and triamterene, unless your doctor has told you to.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.

What should I discuss with my doctor before taking Maxzide (hydrochlorothiazide and triamterene)? You should not use this medication if you are allergic to hydrochlorothiazide (HCTZ, HydroDiuril, Lotensin HCT, Prinzide, Zestoretic, Ziac, and others) or triamterene (Dyrenium), or if you have: kidney disease or are unable to urinate;

high potassium levels (hyperkalemia);

if you are taking diuretics similar to triamterene, such as amiloride (Midamor, Moduretic), spironolactone (Aldactone, Aldactazide); or

if you are taking potassium supplements (unless your doctor tells you to).

To make sure you can safely take hydrochlorothiazide and triamterene, tell your doctor if you have any of these other conditions:

diabetes;

heart disease;

cirrhosis or other liver disease;

glaucoma;

a breathing disorder;

gout;

lupus;

a history of kidney stones;

a pancreas disorder; or

an allergy to sulfa drugs or penicillin.

FDA pregnancy category C. It is not known whether hydrochlorothiazide and triamterene will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Hydrochlorothiazide and triamterene can pass into breast milk and may harm a nursing baby. You should not breast-feed while taking hydrochlorothiazide and triamterene. How should I take Maxzide (hydrochlorothiazide and triamterene)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

You will need regular medical tests to be sure this medication is not causing harmful effects. Visit your doctor regularly.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using hydrochlorothiazide and triamterene.

If you need surgery or a blood transfusion, tell the doctor ahead of time that you are using hydrochlorothiazide and triamterene.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture, heat, and light. What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include increased urination, nausea, vomiting, weakness, fever, warmth or flushing in your face, or muscle spasms.

What should I avoid while taking Maxzide (hydrochlorothiazide and triamterene)? Drinking alcohol can further lower your blood pressure and may increase certain side effects of hydrochlorothiazide and triamterene.

Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.

Do not use potassium supplements, salt substitutes, or low-sodium milk while you are taking hydrochlorothiazide and triamterene, unless your doctor has told you to. Hydrochlorothiazide and triamterene may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Maxzide (hydrochlorothiazide and triamterene) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using hydrochlorothiazide and triamterene and call your doctor at once if you have a serious side effect such as:

eye pain, vision problems;

slow, fast, or uneven heartbeat;

feeling like you might pass out;

swelling or rapid weight gain;

urinating less than usual or not at all;

headache, trouble concentrating, memory problems, weakness, loss of appetite, feeling unsteady, hallucinations, fainting, seizure, shallow breathing or breathing that stops;

low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);

high potassium (irregular heart rate, weak pulse, muscle weakness, tingly feeling);

severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

patchy skin color, red spots, or a butterfly-shaped skin rash over your cheeks and nose (worsens in sunlight);

fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or

jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

mild nausea, diarrhea, constipation;

dizziness, headache;

blurred vision;

dry mouth;

skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs can affect Maxzide (hydrochlorothiazide and triamterene)? Before using hydrochlorothiazide and triamterene, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by hydrochlorothiazide and triamterene.

Tell your doctor about all other medicines you use, especially:

lithium (Eskalith, LithoBid);

amphotericin B (Amphotec, AmBisome, Abelcet);

methenamine (Hipprex, Mandelamine, Urex);

gout medication such as allopurinol (Zyloprim), colchicine (Colcrys), or probenecid (Benemid);

steroid medication (prednisone and others);

a blood thinner such as warfarin (Coumadin, Jantoven);

insulin or oral diabetes medication;

laxatives;

an ACE inhibitor such as benazepril (Lotensin), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others; or

indomethacin (Indocin) or other NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others.

This list is not complete and other drugs may interact with hydrochlorothiazide and triamterene. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Maxzide resources Maxzide Side Effects (in more detail)Maxzide Use in Pregnancy & BreastfeedingDrug ImagesMaxzide Drug InteractionsMaxzide Support Group2 Reviews for Maxzide - Add your own review/rating Maxzide Prescribing Information (FDA) Maxzide Advanced Consumer (Micromedex) - Includes Dosage Information Maxzide MedFacts Consumer Leaflet (Wolters Kluwer) Dyazide Prescribing Information (FDA) Dyazide Consumer Overview Compare Maxzide with other medications EdemaHigh Blood Pressure Where can I get more information? Your pharmacist can provide more information about hydrochlorothiazide and triamterene.

See also: Maxzide side effects (in more detail)

Malignant Pleural Effusion Medications
Drugs associated with Malignant Pleural Effusion

The following drugs and medications are in some way related to, or used in the treatment of Malignant Pleural Effusion. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Learn more about Malignant Pleural Effusion

Micromedex Care Notes:

Pleural EffusionPleurisy Drug List:Blenoxane

Fungizone For Tissue Culture

Generic Name: amphotericin B (am foe TER i sin) Brand Names: Fungizone, Fungizone For Tissue Culture

What is Fungizone For Tissue Culture (amphotericin B)?

Amphotericin B is an antibiotic that fights fungal infections in the body.

Amphotericin B is used to treat serious, life-threatening fungal infections. It is not for use in treating a minor fungal infection such as a yeast infection of the mouth, esophagus, or vagina.

Amphotericin is usually given after other antifungal antibiotics have been tried without successful treatment of symptoms.

Amphotericin B may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Fungizone For Tissue Culture (amphotericin B)? Do not receive this medication if you are allergic to any formulation of amphotericin B (Abelcet, AmBisome, Amphotec, or Fungizone).

Before you receive amphotericin B, tell your doctor if you are allergic to any drugs, or if you have kidney disease or heart disease.

Amphotericin B is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting.

The medicine must be given slowly through an IV infusion, and can take up to 6 hours to complete.

Amphotericin B may need to be given for up to several weeks or months, depending on the infection being treated.

Some people receiving an amphotericin B injection have had a reaction to the infusion (either when the medicine is injected into the vein or within 1 to 3 hours afterward). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, feverish or cold, or if have a slow heartbeat, chest tightness, or trouble breathing. What should I discuss with my health care provider before I receive Fungizone For Tissue Culture (amphotericin B)? You should not receive this medication if you are allergic to any formulation of amphotericin B (Abelcet, AmBisome, Amphotec, or Fungizone).

Before you receive amphotericin B, tell your doctor if you are allergic to any drugs, or if you have:

kidney disease; or

heart disease.

If you have any of these conditions, you may need a dose adjustment or special tests to safely receive amphotericin B.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether amphotericin B passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby. How is amphotericin B given?

Amphotericin B is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting.

The medicine must be given slowly through an IV infusion, and can take up to 6 hours to complete.

While you are receiving your amphotericin B infusion, your caregivers will check your blood pressure, pulse, temperature, and lung function about every 30 minutes.

To be sure this medication is not causing harmful effects, your blood cells, kidney function, and liver function may need to be tested on a regular basis. Amphotericin B can have long-lasting effects on your body. Do not miss any follow-up visits to your doctor for blood or urine tests.

Amphotericin B may need to be given for up to several weeks or months, depending on the infection being treated.

What happens if I miss a dose?

Since amphotericin B is usually given while you are in the hospital, it is not likely you will miss a dose of this medication.

If you are receiving amphotericin B in an outpatient clinic, call your doctor if you will miss an appointment for your amphotericin B injection.

What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include slow heart rate, and shallow breathing that slows or stops.

What should I avoid while receiving Fungizone For Tissue Culture (amphotericin B)?

Amphotericin B may lower the blood cells that help your body fight other infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Fungizone For Tissue Culture (amphotericin B) side effects Some people receiving an amphotericin B injection have had a reaction to the infusion (either when the medicine is injected into the vein or within 1 to 3 hours afterward). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, feverish or cold, or if you have a slow heartbeat, chest tightness, or trouble breathing. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your doctor at once if you have any of these serious side effects:

dry mouth, increased thirst, nausea, vomiting;

extreme drowsiness, restless feeling, confusion;

urinating more or less than usual, or not at all;

muscle pain or weakness, fast or uneven heart rate, feeling light-headed, fainting;

seizure (convulsions);

fever, chills, body aches, flu symptoms;

pale skin, easy bruising or bleeding, unusual weakness; or

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

pain, swelling, or other irritation where the needle is placed;

mild nausea, vomiting, diarrhea, upset stomach, loss of appetite;

weight loss;

muscle or joint aches;

headache;

warmth, redness, or tingly feeling under your skin; or

skin itching or mild rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Fungizone For Tissue Culture (amphotericin B)?

Before receiving amphotericin B, tell your doctor if you are using any of the following drugs:

flucytosine (Ancobon);

digoxin (digitalis, Lanoxin, Lanoxicaps);

pentamidine (Nebupent, Pentam);

tacrolimus (Prograf);

muscle relaxers;

steroids (prednisone and others);

antifungal antibiotics such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), ketoconazole (Nizoral), or itraconazole (Sporanox);

antibiotics such as capreomycin (Capastat), rifampin (Rifadin, Rimactane, Rifater), vancomycin (Vancocin, Vancoled);

antiviral medicines such as acyclovir (Zovirax), adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir); or

cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), plicamycin (Mithracin), streptozocin (Zanosar), or tretinoin (Vesanoid).

This list is not complete and there may be other drugs that can interact with amphotericin B. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Fungizone For Tissue Culture resources Fungizone For Tissue Culture Side Effects (in more detail)Fungizone For Tissue Culture Use in Pregnancy & BreastfeedingFungizone For Tissue Culture Drug Interactions0 Reviews for Fungizone For Tissue Culture - Add your own review/rating Amphocin MedFacts Consumer Leaflet (Wolters Kluwer) Amphocin Advanced Consumer (Micromedex) - Includes Dosage Information Amphotericin B Prescribing Information (FDA) Amphotericin B Monograph (AHFS DI) Amphotericin B Professional Patient Advice (Wolters Kluwer) Fungizone Prescribing Information (FDA) Compare Fungizone For Tissue Culture with other medications Aspergillosis, AspergillomaAspergillosis, InvasiveBlastomycosisCandida Infections, SystemicCandida Urinary Tract InfectionCoccidioidomycosisCoccidioidomycosis, MeningitisCryptococcal Meningitis, Immunocompetent HostCryptococcal Meningitis, Immunosuppressed HostCryptococcosisEsophageal CandidiasisFungal EndocarditisFungal Infection ProphylaxisHistoplasmosis, Immunocompenent HostHistoplasmosis, MeningitisLeishmaniasisOral ThrushParacoccidioidomycosisSporotrichosis Where can I get more information? Your pharmacist can provide more information about amphotericin B.

See also: Fungizone For Tissue Culture side effects (in more detail)

Metrotop (Molnlycke Health Care )
1. Name Of The Medicinal Product

Metrotop.

2. Qualitative And Quantitative Composition

Metronidazole BP 0.8% w/v.

3. Pharmaceutical Form

A colourless aqueous gel.

4. Clinical Particulars 4.1 Therapeutic Indications

For the treatment of malodorous fungating tumours, gravitational ulcers and decubitus ulcers (pressure sores).

4.2 Posology And Method Of Administration

For external use only. Adults: All wounds should be cleaned thoroughly. Flat wounds require a liberal application of the gel over the complete area. Cavities should be loosely packed with paraffin gauze which has been smeared in the gel. All wounds should be covered with a non-adherent dressing and a pad of lint or gauze. Sticking may occur if the appropriate dressing is not used. Use once or twice daily as necessary. Elderly: No specific instructions. Children: Where necessary, instructions apply as for adults.

4.3 Contraindications

Known hypersensitivity to metronidazole.

4.4 Special Warnings And Precautions For Use

The following statements take into account the possibility that metronidazole may be absorbed after topical application. However, there is no evidence of any significant systemic concentrations of metronidazole following topical applications. Peripheral neuropathy has been reported in association with prolonged use of metronidazole. The elimination half-life of metronidazole remains unchanged in the presence of renal failure. Such patients, however, retain the metabolite of metronidazole. The clinical significance of this is not known at present. However, in patients undergoing dialysis, metronidazole and metabolites are efficiently removed.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Some potentiation of anticoagulant therapy has been reported when metronidazole has been used with the warfarin type oral anticoagulants. Patients receiving phenobarbitone metabolise metronidazole at a much faster rate than normal, reducing the half-life to approximately 3 hours. Patients are advised not to take alcohol during systemic metronidazole therapy because of the possibility of a disulfiram-like reaction.

4.6 Pregnancy And Lactation

There is inadequate evidence of the use of metronidazole in pregnancy. Metronidazole gel cannot therefore be recommended during pregnancy or lactation where significant systemic absorption may occur unless the physician considers it essential.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

No adverse effects have been reported. Systemic metronidazole therapy may occasionally cause an unpleasant taste in the mouth, furred tongue, nausea, vomiting, gastrointestinal disturbance, urticaria, angioedema and anaphylaxis. Drowsiness, dizziness, headache, ataxia, skin rash, pruritus, and darkening of the urine have been reported, but rarely.

4.9 Overdose

There is no specific treatment for gross overdosage of metronidazole. Gastric lavage is recommended in cases of accidental ingestion. Uneventful recovery has followed overdosage of up to 12g taken orally. Metronidazole is readily removed from the plasma by dialysis.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Metronidazole is a potent agent against the anaerobic bacteria which are believed to produce odorous metabolites as a result of localised tissue colonisation. The aim of the product is to provide a high concentration of metronidazole at and around the site of colonisation in a water-miscible base. This form allows surface spread and penetration within the wound accompanied by ease of aseptic application and up to 24 hours duration of action.

5.2 Pharmacokinetic Properties

There is presently no evidence of any systemic concentrations of metronidazole following topical application.

5.3 Preclinical Safety Data

No further data given.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Hypromellose (4500); benzalkonium chloride solution; purified water.

6.2 Incompatibilities

None known.

6.3 Shelf Life

The shelf life shall not exceed 24 months from the date of manufacture.

6.4 Special Precautions For Storage

Do not store above 25°C. Once opened the contents should be used within 28 days of opening.

6.5 Nature And Contents Of Container

Polypropylene tubes each fitted with a plastic screw cap and tamper-evident seal and enclosed within a printed cardboard carton. Single tubes may sometimes be supplied without a carton. Pack sizes: The 15g, 30g and 60g tubes are available singly or in boxes of 12.

6.6 Special Precautions For Disposal And Other Handling

None given.

7. Marketing Authorisation Holder

Medlock Medical Limited, Tubiton House, Medlock Street, Oldham, OL1 3HS.

8. Marketing Authorisation Number(S)

PL 21248/0040.

9. Date Of First Authorisation/Renewal Of The Authorisation

16th September 2005.

10. Date Of Revision Of The Text

September 2005.

Infadin

Infadin may be available in the countries listed below.

Ingredient matches for Infadin Ergocalciferol

Ergocalciferol is reported as an ingredient of Infadin in the following countries:

Czech Republic Slovakia

International Drug Name Search

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