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Para-Time S.R.

Generic Name: papaverine (Oral route)

pa-PAV-er-een

Commonly used brand name(s)

In the U.S.

Papacon Para-Time S.R. Pavacot

Available Dosage Forms:

Capsule, Extended Release Tablet

Therapeutic Class: Peripheral Vasodilator

Uses For Para-Time S.R.

Papaverine belongs to the group of medicines called vasodilators. Vasodilators cause blood vessels to expand, thereby increasing blood flow. This medicine is used to treat problems resulting from poor blood circulation.

Papaverine is available only with your doctor's prescription.

Before Using Para-Time S.R.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of papaverine in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Papaverine may reduce tolerance to cold temperatures in elderly patients.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Ginkgo Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Angina (chest pain) or Glaucoma or Heart disease or Myocardial infarction (heart attack), recent, or Stroke, recent—The chance of unwanted effects may be increased. Proper Use of papaverine

This section provides information on the proper use of a number of products that contain papaverine. It may not be specific to Para-Time S.R.. Please read with care.

If this medicine upsets your stomach, it may be taken with meals, milk, or antacids.

For patients taking the extended-release capsule form of this medicine:

Swallow the capsule whole. Do not crush, break, or chew before swallowing. However, if the capsule is too large to swallow, you may mix the contents with jam or jelly and swallow without chewing. Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (extended-release capsules): Adults: 150 milligrams (mg) every twelve hours. The dose may be increased to 150 mg every eight hours or 300 mg every twelve hours. For oral dosage form (tablets): Adults: 100 to 300 milligrams (mg) three to five times a day. Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Para-Time S.R.

It may take some time for this medicine to work. If you feel that the medicine is not working, do not stop taking it on your own. Instead, check with your doctor.

The helpful effects of this medicine may be decreased if you smoke. If you have any questions about this, check with your doctor.

Dizziness may occur, especially when you get up from a lying or sitting position or climb stairs. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

Para-Time S.R. Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare Abdominal pain or tenderness blurred or double vision change in ability to see colors, especially blue or yellow clay-colored stools dark urine decreased appetite deep, slow breathing drowsiness fatigue fever headache insomnia itching loss of appetite nausea and vomiting painful or prolonged erection of the penis skin rash swelling of the feet or lower legs trouble with breathing unusual tiredness or weakness vomiting weakness yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common Constipation diarrhea dizziness or lightheadedness fainting fast, pounding, or irregular heartbeat or pulse feeling of constant movement of self or surroundings flushed face itching skin nervousness palpitations pounding in the ears sensation of spinning sleepiness or unusual drowsiness slow or fast heartbeat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Para-Time S.R. side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Para-Time S.R. resources Para-Time S.R. Side Effects (in more detail)Para-Time S.R. Use in Pregnancy & BreastfeedingDrug ImagesPara-Time S.R. Drug InteractionsPara-Time S.R. Support Group0 Reviews · Be the first to review/rate this drug

L-M-X4 Cream
Pronunciation: L Y E-doe-caneGeneric Name: LidocaineBrand Name: Examples include L-M-X4 and LidaMantle

Simple Linctus Sugar Free (Pinewood Healthcare)
1. Name Of The Medicinal Product

Simple Linctus Sugar Free

2. Qualitative And Quantitative Composition

Simple Linctus Sugar Free: Citric Acid Monohydrate 125 mg/5 ml equivalent to 114.29mg/5ml Anhydrous Citric Acid.

3. Pharmaceutical Form

Clear Pink Sugar Free Syrup

4. Clinical Particulars 4.1 Therapeutic Indications

For the management of a mild non-specific cough.

4.2 Posology And Method Of Administration

Adults: One 5 ml spoonful orally 3-4 times daily.

Children: Not appropriate

4.3 Contraindications

Not known

4.4 Special Warnings And Precautions For Use

This medicine contains maltitol liquid. Patients with rare hereditary problems of fructose intolerance should not take this medicine.

This medicinal product contains small amounts of ethanol (alcohol), less than 100mg per 5ml dose

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None Known

4.6 Pregnancy And Lactation

No data available

4.7 Effects On Ability To Drive And Use Machines

Not applicable

4.8 Undesirable Effects

Not Applicable

4.9 Overdose

Sufficient prolonged overdose of citric acid may cause erosion of the teeth and have a local irritant action.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Absorption: Citric Acid Monohydrate is absorbed after oral administration.

Distribution: Citric Acid is found naturally in the body and is widely distributed, about 70% of the citric acid in the body is in hard bone and this accounts for 1.5% of bone content.

Metabolic Reactions: It is an important intermediate in carbohydrate metabolism and its major role is in the tricarboxylic acid cycle (Krebs citric acid cycle); it is metabolised to carbon dioxide and water.

Excretion: Citric acid is normally excreted in the urine in amounts ranging from 0.4 to 1.5g daily and this amount is not increased unless very large doses are administered. The urinary excretion of citric acid is increased in alkaline urine

5.2 Pharmacokinetic Properties

Not applicable

5.3 Preclinical Safety Data

None stated

6. Pharmaceutical Particulars 6.1 List Of Excipients

Glycerol (E422)

Sodium Carboxymethylcellulose

Sodium Benzoate (E211)

Saccharin Sodium (E954)

Lycasin 80/55 (E965)

Ethanol (96%)

Anise Oil

Chloroform

Natural Red DI (E163)

Purified Water

6.2 Incompatibilities

Not appropriate

6.3 Shelf Life

2 years

6.4 Special Precautions For Storage

Do not Store above 25°C.

6.5 Nature And Contents Of Container

Amber glass bottles with pilfer screw closure

High density Polyethylene with screw on closure

Pack sizes of 100ml, 125ml, and 200ml for Amber Glass Bottles

Pack size of 2000ml for High Density Polyethylene dispensary pack.

6.6 Special Precautions For Disposal And Other Handling

As with all medicines.

7. Marketing Authorisation Holder

Pinewood Laboratories Limited

Ballymacarbry

Clonmel

Co Tipperary

8. Marketing Authorisation Number(S)

PL 04917/0006

9. Date Of First Authorisation/Renewal Of The Authorisation

28 August 1991

10. Date Of Revision Of The Text

November 2008

NTZ Long Acting Nasal

Generic Name: oxymetazoline nasal (ox ee me TAZ oh leen) Brand Names: Afrin, Afrin Nasal Sinus, Allerest 12 Hour Nasal Spray, Duramist Plus, Duration, Four-Way Nasal Spray, Genasal, Neo-Synephrine 12 Hour, Nostrilla, NRS Nasal, NTZ Long Acting Nasal, Oxyfrin, Oxymeta-12, Sinarest Nasal, Sinex Long-Acting, Twice-A-Day

What is NTZ Long Acting Nasal (oxymetazoline nasal)?

Oxymetazoline is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in your body. The nasal formulation acts directly on the blood vessels in your nasal tissues. Constriction of the blood vessels in your nose and sinuses leads to drainage of these areas and a decrease in congestion.

Oxymetazoline nasal is used to treat congestion associated with allergies, hay fever, sinus irritation, and the common cold.

Oxymetazoline nasal may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about NTZ Long Acting Nasal (oxymetazoline nasal)?

Do not use oxymetazoline nasal for longer than 3 to 5 days. Longer use could cause damage to your nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.

Do not use more of this medication than is recommended on the package or by your doctor. Who should not use NTZ Long Acting Nasal (oxymetazoline nasal)? Do not use oxymetazoline nasal if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. This could cause a very dangerous drug interaction with serious side effects.

Before taking this medication, tell your doctor if you have

high blood pressure;

any type of heart disease, hardening of the arteries, or irregular heart beats;

thyroid problems;

diabetes;

glaucoma or increased pressure in the eye;

an enlarged prostate or difficulty urinating; or

liver or kidney disease.

You may not be able to use oxymetazoline nasal, or you may require a lower dose or special monitoring during your therapy if you have any of the conditions listed above.

It is not known whether oxymetazoline nasal will harm an unborn baby. Do not use oxymetazoline nasal without first talking to your doctor if you are pregnant. Infants are especially sensitive to the effects of oxymetazoline nasal. Do not use this medication without first talking to your doctor if you are breast-feeding a baby. If you over 60 years of age, you may be more likely to experience side effects from oxymetazoline nasal. You may require a lower dose of this medication. How should I use NTZ Long Acting Nasal (oxymetazoline nasal)?

Use oxymetazoline nasal exactly as directed by your doctor, or follow the instructions that accompany the package. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

To apply the nasal spray, keep your head upright, spray, then sniff hard for a few minutes after administering a dose.

To apply the nasal drops, lie on a bed on your back with your head hanging over the edge. Insert the drops and remain in this position for several minutes. Gently turn your head from side to side.

Do not allow the tip of the container to touch the inside of your nose or any other surface. This spreads the infection.

Also, to prevent the spread of infection, do not share this medication with anyone else.

Discard this medication bottle after use. Do not save it for reuse.

Never use this medication in larger doses or more often than is recommended. Too much oxymetazoline nasal could be very harmful. Oxymetazoline nasal should not be used more often than twice a day (every 12 hours).

Do not use oxymetazoline nasal for longer than 3 to 5 days. Longer use could cause damage to your nasal tissue and lead to chronic congestion. If your symptoms do not improve, see your doctor.

Store oxymetazoline nasal at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and use the next one as directed. Do not use a double dose of this medication.

What happens if I overdose? Seek emergency medical attention.

Symptoms of an oxymetazoline nasal overdose include extreme tiredness, sweating, dizziness, a slow heartbeat, and coma.

What should I avoid while taking NTZ Long Acting Nasal (oxymetazoline nasal)? Never use this medication in larger doses or more often than is recommended. Too much oxymetazoline nasal could be very harmful. NTZ Long Acting Nasal (oxymetazoline nasal) side effects

If you experience any of the following serious side effects, stop using oxymetazoline nasal and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

seizures;

unusual behavior or hallucinations; or

an irregular or fast heartbeat.

More commonly, you may experience some sneezing or burning, stinging, dryness, or irritation of the nose. These side effects are usually mild and temporary.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect NTZ Long Acting Nasal (oxymetazoline nasal)? Do not use oxymetazoline nasal if you have taken a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.

Although drug interactions between topical nasal decongestants and drugs taken by mouth are not expected, they can occur. Rarely, oxymetazoline nasal may interact with the following medicines:

furazolidone (Furoxone);

guanethidine (Ismelin);

indomethacin (Indocin);

methyldopa (Aldomet);

bromocriptine (Parlodel);

caffeine in cola, tea, coffee, chocolate and other products;

theophylline (Theo-Dur, Theochron, Theolair, others);

tricyclic antidepressants such as amitriptyline (Elavil, Endep), doxepin (Sinequan), and nortriptyline (Pamelor); other commonly used tricyclic antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), protriptyline (Vivactil), and trimipramine (Surmontil); phenothiazines such as chlorpromazine (Thorazine), thioridazine (Mellaril), and prochlorperazine (Compazine); and other commonly used phenothiazines, including fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), and trifluoperazine (Stelazine).

Drugs other than those listed here may also interact with oxymetazoline nasal. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More NTZ Long Acting Nasal resources NTZ Long Acting Nasal Side Effects (in more detail)NTZ Long Acting Nasal Use in Pregnancy & BreastfeedingNTZ Long Acting Nasal Drug InteractionsNTZ Long Acting Nasal Support Group0 Reviews for NTZ Long Acting Nasal - Add your own review/rating Afrin Advanced Consumer (Micromedex) - Includes Dosage Information Afrin Solution MedFacts Consumer Leaflet (Wolters Kluwer) Compare NTZ Long Acting Nasal with other medications Nasal Congestion Where can I get more information? Your pharmacist has additional information about oxymetazoline nasal written for health professionals that you may read.

See also: NTZ Long Acting Nasal side effects (in more detail)

Potassium Chloride Solution
Pronunciation: po-TAS-ee-um KLOR-ideGeneric Name: Potassium ChlorideBrand Name: Generic only. No brands available.

Efudex Occlusion Pack

Generic Name: fluorouracil topical (flore oh YER a sill) Brand Names: Carac, Efudex, Efudex Occlusion Pack, Fluoroplex

What is Efudex Occlusion Pack (fluorouracil topical)?

Fluorouracil interferes with the growth of skin cells. Fluorouracil works by causing the death of cells which are growing fastest, such as abnormal skin cells.

Fluorouracil topical is used to treat scaly overgrowths of skin (actinic or solar keratoses). Fluorouracil topical may also be used in the treatment of superficial basal cell carcinoma.

Fluorouracil topical may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Efudex Occlusion Pack (fluorouracil topical)? Do not use fluorouracil topical on skin that is irritated, peeling, or infected or on open wounds. Wait until these conditions have fully healed before using fluorouracil topical. Fluorouracil topical is in the FDA pregnancy category X. This means that it is known to harm an unborn baby. Miscarriage and birth defects have been reported when fluorouracil topical was applied to mucous membrane areas by pregnant women. Do not use fluorouracil topical if you are pregnant or planning a pregnancy. Discuss with your doctor appropriate forms of birth control before starting treatment with fluorouracil topical.

Fluorouracil topical is available in a number of strengths and forms (creams and solutions). It is very important that you use the correct form and strength. Contact your doctor or pharmacist if you have questions regarding which product to use.

Avoid exposure to sunlight or artificial UV rays (e.g., sun lamps) during and immediately following treatment with fluorouracil topical. Use a sunscreen with a minimum sun protection factor (SPF) 15 and wear protective clothing when sun exposure is unavoidable. Individuals with fair skin may require a sunscreen with a higher SPF rating. What should I discuss with my healthcare provider before using Efudex Occlusion Pack (fluorouracil topical)?

Before using fluorouracil topical, tell your doctor if you:

have ever had an allergic reaction to another form of fluorouracil topical (Carac, Efudex, Fluoroplex) or injectable fluorouracil (Adrucil, 5-FU); or

have dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.

You may not be able to use fluorouracil topical, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Fluorouracil topical is in the FDA pregnancy category X. This means that it is known to harm an unborn baby. Miscarriage and birth defects have been reported when fluorouracil topical was applied to mucous membrane areas by pregnant women. Do not use fluorouracil topical if you are pregnant or planning a pregnancy. Discuss with your doctor appropriate forms of birth control before starting treatment with fluorouracil topical. It is not known whether fluorouracil topical passes into breast milk. Do not use fluorouracil topical without first talking to your doctor if you are breast-feeding a baby. The safety and effectiveness of fluorouracil topical in patients younger than 18 years of age have not been established. How should I use Efudex Occlusion Pack (fluorouracil topical)?

Use fluorouracil topical exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Clean the area where you will apply fluorouracil topical. Rinse well and dry the area with a towel and wait ten minutes before applying the medication.

Wash your hands before and immediately after applying this medication, unless it is being used to treat a hand condition.

Apply fluorouracil topical to the affected area with the finger tips or a non-metal applicator, smoothing it gently onto the affected skin. Use enough to cover the entire area with a thin film.

Fluorouracil topical should not be applied on the eyelids or in the eyes, nose, or mouth. Use caution when applying fluorouracil topical around the eyes, nose, or mouth. Do not use fluorouracil topical on skin that is irritated, peeling, or infected or on open wounds. Wait until these conditions have fully healed before using fluorouracil topical.

Do not cover the area after applying fluorouracil topical. This could cause too much medicine to be absorbed by the body and could be harmful. If a covering is needed, ask your doctor if a porous gauze dressing may be used.

A moisturizer or sun screen may be applied 2 hours after fluorouracil topical has been applied. Do not use any other skin products including creams, lotions, medications, or cosmetics unless instructed by your doctor.

The reaction of the skin treated with fluorouracil topical may be unsightly during treatment, and sometimes, for several weeks after completion of therapy.

Store fluorouracil topical at room temperature away from moisture and heat. What happens if I miss a dose?

Apply the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and apply only the next regularly scheduled dose. Do not apply a double dose of this medication.

What happens if I overdose? An overdose of fluorouracil topical is unlikely to occur. If you do suspect an overdose, or if fluorouracil topical has been ingested, call a poison control center or an emergency room for advice. What should I avoid while using Efudex Occlusion Pack (fluorouracil topical)? Do not use other prescription or over-the-counter skin products without first talking to your doctor during treatment with fluorouracil topical. They may interfere with the treatment or increase irritation of the skin. Avoid exposure to sunlight or artificial UV rays (e.g., sun lamps) during and immediately following treatment with fluorouracil topical. Use a sunscreen with a minimum sun protection factor (SPF) 15 and wear protective clothing when sun exposure is unavoidable. Individuals with fair skin may require a sunscreen with a higher SPF rating. Efudex Occlusion Pack (fluorouracil topical) side effects Serious side effects are not likely to occur. Stop using fluorouracil topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

Fluorouracil topical may cause skin irritation, dryness, scaling or peeling (exfoliation), rash, and other local reactions. Eye irritation has also been reported. If these side effects are excessive or worsen with continued treatment, contact your doctor.

What other drugs will affect Efudex Occlusion Pack (fluorouracil topical)? Do not use other prescription or over-the-counter skin products without first talking to your doctor during treatment with fluorouracil topical. They may interfere with treatment or increase irritation to the skin.

Drugs other than those listed here may also interact with fluorouracil topical. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More Efudex Occlusion Pack resources Efudex Occlusion Pack Side Effects (in more detail)Efudex Occlusion Pack Use in Pregnancy & BreastfeedingEfudex Occlusion Pack Support Group0 Reviews for Efudex Occlusion Pack - Add your own review/rating Carac Cream MedFacts Consumer Leaflet (Wolters Kluwer) Carac Prescribing Information (FDA) Carac Topical Advanced Consumer (Micromedex) - Includes Dosage Information Efudex Prescribing Information (FDA) Fluoroplex Prescribing Information (FDA) Compare Efudex Occlusion Pack with other medications Actinic KeratosisBasal Cell CarcinomaSkin Cancer Where can I get more information? Your pharmacist has additional information about fluorouracil topical written for health professionals that you may read.

See also: Efudex Occlusion Pack side effects (in more detail)

Viagra
Pronunciation: sil-DEN-a-filGeneric Name: SildenafilBrand Name: Viagra

Boots Antiseptic Wound Wash
1. Name Of The Medicinal Product

First Aid Antiseptic Spray or Boots Antiseptic Wound Wash

2. Qualitative And Quantitative Composition

Cetrimide

0.5 % w/v

3. Pharmaceutical Form

Liquid

4. Clinical Particulars 4.1 Therapeutic Indications

For cuts, grazes, insect bites, minor wounds, spots, minor burns and scalds.

4.2 Posology And Method Of Administration

For topical application.

Adults, children and the elderly

Hold upright and spray from a distance of 2 to 4 inches on the affected area.

Spray the affected area two or three times a day.

4.3 Contraindications

Hypersensitivity to any of the ingredients.

4.4 Special Warnings And Precautions For Use

Prolonged and repeated administration may lead to hypersensitivity.

Do not use if the skin is weeping or badly inflamed.

Avoid contact with the eyes.

For external use only.

Keep all medicines out of the reach of children.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

There are no clinically significant interactions.

4.6 Pregnancy And Lactation

The safety of First Aid Antiseptic Spray during pregnancy and lactation has not been established but it is not considered to constitute a hazard during these periods.

4.7 Effects On Ability To Drive And Use Machines

No adverse effects known.

4.8 Undesirable Effects

Skin irritation may occasionally occur and hypersensitivity reactions may develop in certain individuals.

4.9 Overdose

It is unlikely that systemic toxicity will result from the ingestion of First aid Antiseptic Spray, although it may give rise to gastrointestinal irritation.

Treatment should be symptomatic.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Cetrimide is a quaternary ammonium disinfectant having bactericidal activity against both gram-positive and gram-negative organisms.

5.2 Pharmacokinetic Properties

None stated.

5.3 Preclinical Safety Data

Not applicable.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Sodium citrate

Anhydrous citric acid

Di-Sodium edetate

Purified water

6.2 Incompatibilities

None stated

6.3 Shelf Life

36 months

6.4 Special Precautions For Storage

None stated

6.5 Nature And Contents Of Container

Polythene bottle 100 ml with plastic spray pump of 50 microlitre dosage.

6.6 Special Precautions For Disposal And Other Handling

Hold upright and spray from a distance of 2 to 4 inches on the affected area.

7. Marketing Authorisation Holder

The Boots Company PLC

1 Thane Road West

Nottingham NG2 3AA

8. Marketing Authorisation Number(S)

PL 00014/0507

9. Date Of First Authorisation/Renewal Of The Authorisation

11 April 1997

10. Date Of Revision Of The Text

December 2004

Ammonia N-13
FULL PRESCRIBING INFORMATION Indications and Usage for Ammonia N-13

Ammonia N 13 Injection is indicated for diagnostic Positron Emission Tomography (PET) imaging of the myocardium under rest or pharmacologic stress conditions to evaluate myocardial perfusion in patients with suspected or existing coronary artery disease.

Ammonia N-13 Dosage and Administration

Rest Imaging Study Aseptically withdraw Ammonia N 13 Injection from its container and administer 10-20 mCi (0.368 – 0.736 GBq) as a bolus through a catheter inserted into a large peripheral vein.

Prednisol

Generic Name: prednisolone ophthalmic (pred NIS oh lone) Brand Names: Econopred Plus, Omnipred, Pred Forte, Pred Mild, Prednisol

What is Prednisol (prednisolone ophthalmic)?

Prednisolone is a steroid medicine. It prevents the release of substances in the body that cause inflammation.

Prednisolone ophthalmic (for the eyes) is used to treat eye swelling caused by allergy, infection, injury, surgery, or other conditions.

Prednisolone ophthalmic may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Prednisol (prednisolone ophthalmic)? You should not use this medication if you are allergic to prednisolone or other steroids, or if you have certain types of infection (viral, fungal, or bacterial) that can affect your eyes.

Before using prednisolone ophthalmic, tell your doctor if you have glaucoma, herpes, or if you have recently had cataract surgery.

Do not use prednisolone ophthalmic while you are wearing contact lenses. This medication may contain a preservative that can be absorbed by soft contact lenses and cause discoloration. Wait at least 15 minutes after using prednisolone before putting your contact lenses in. Shake the eye drops gently before each use.

Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

If you still have pain or swelling after 2 days of treatment, stop using this medication and call your doctor. Do not stop using prednisolone ophthalmic suddenly after long-term use without first talking to your doctor. You may need to use less and less before you stop the medication completely. What should I discuss with my healthcare provider before using Prednisol (prednisolone ophthalmic)? You should not use this medication if you are allergic to prednisolone or other steroids, or if you have certain types of infection (viral, fungal, or bacterial) that can affect your eyes.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use prednisolone ophthalmic:

glaucoma;

recent cataract surgery; or

herpes simplex.

FDA pregnancy category C. It is not known whether prednisolone ophthalmic is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether prednisolone ophthalmic passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I use Prednisol (prednisolone ophthalmic)?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Wash your hands before using prednisolone ophthalmic.

To apply the eye drops:

Shake the bottle gently before each use to be sure the medicine is well mixed.

Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.

Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop.

Use only the number of drops your doctor has prescribed.

If you use prednisolone ophthalmic for longer than 10 days, your eyes will need to be checked on a regular basis. Do not miss any scheduled visits to your doctor.

Store this medication at room temperature away from moisture and heat. Keep the bottle or tube tightly capped. Do not allow this medicine to freeze. What happens if I miss a dose?

Use the medication as soon as you remember the missed dose. If it is almost time for your next dose, skip the missed dose and use the medicine at your next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of prednisolone ophthalmic is not expected to produce life-threatening symptoms.

What should I avoid while using Prednisol (prednisolone ophthalmic)? Do not wear any contact lens that has not been approved by your doctor.

Do not use any other eye medications unless your doctor has prescribed them.

Prednisolone ophthalmic can cause side effects that may impair your vision. Be careful if you drive or do anything that requires you to see clearly. Prednisol (prednisolone ophthalmic) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

pain behind your eyes, sudden vision changes, severe headache;

sudden eye irritation;

blurred vision, tunnel vision, eye pain, or seeing halos around lights; or

signs of new eye infection, such as swelling, draining, or crusting of your eyes.

Less serious side effects may include:

temporary cloudy vision;

increased sensitivity to light; or

mild stinging, burning, itching, or irritation in your eyes.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Prednisol (prednisolone ophthalmic)?

It is not likely that other drugs you take orally or inject will have an effect on prednisolone used in the eyes. But many drugs can interact with each other. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Prednisol resources Prednisol Side Effects (in more detail)Prednisol Use in Pregnancy & BreastfeedingPrednisol Drug InteractionsPrednisol Support Group0 Reviews for Prednisol - Add your own review/rating AK-Pred Drops MedFacts Consumer Leaflet (Wolters Kluwer) Econopred Prescribing Information (FDA) Econopred Plus Drops MedFacts Consumer Leaflet (Wolters Kluwer) Econopred Plus Prescribing Information (FDA) Omnipred Prescribing Information (FDA) Pred Forte Prescribing Information (FDA) Prednisolone Monograph (AHFS DI) Prednisolone Acetate eent Monograph (AHFS DI) Compare Prednisol with other medications Postoperative Ocular Inflammation Where can I get more information? Your pharmacist can provide more information about prednisolone ophthalmic.

See also: Prednisol side effects (in more detail)

Allerfrim Liquid
Pronunciation: soo-doe-e-FED-rin/try-PRO-li-deenGeneric Name: Pseudoephedrine/TriprolidineBrand Name: Examples include Allerfrim and Zymine-D

Monopril HCT
Pronunciation: fos-IN-oh-pril/HYE-droe-KLOR-oh-THYE-a-zideGeneric Name: Fosinopril/HydrochlorothiazideBrand Name: Monopril HCT

Amphadase

Generic Name: hyaluronidase (Subcutaneous route, Injection route)

hye-al-ure-ON-i-dase

Commonly used brand name(s)

In the U.S.

Amphadase Hydase Hylenex Vitrase

Available Dosage Forms:

Powder for Solution Solution

Therapeutic Class: Tissue Permeability Modifier

Pharmacologic Class: Enzyme

Uses For Amphadase

Hyaluronidase is a natural substance found in the body. Hyaluronidase is collected from either cows or pigs. It is cleaned up to remove animal substances. Hyaluronidase is a spreading substance. Hyaluronidase is used with other drugs given under the skin to improve their uptake by the body. This method of drug delivery is only used when the drug cannot be given by injection into a vein.

This medicine is available only with your doctor's prescription.

Before Using Amphadase

Allergies

Pediatric

This medicine has been tested in children and, in effective doses, has not been shown to cause different side effects or problems than it does in adults.

Geriatric

This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Interactions with Medicines

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Benzocaine Bupivacaine Butacaine Chloroprocaine Cocaine Dibucaine Etidocaine Lidocaine Mepivacaine Prilocaine Procaine Proparacaine Propoxycaine Ropivacaine Tetracaine Interactions with Food/Tobacco/Alcohol

Other Medical Problems

The presence of other medical problems may affect the use of hyaluronidase. Make sure you tell your doctor if you have any other medical problems.

Proper Use of hyaluronidase

This section provides information on the proper use of a number of products that contain hyaluronidase. It may not be specific to Amphadase. Please read with care.

Dosing

For injection dosage form: For better uptake of other drugs: Adults—Use and dose must be determined by your doctor. Children—Use and dose must be determined by your doctor. Storage

Store in the refrigerator. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Amphadase

Some people may be allergic to this medicine. Tell your doctor if you develop red or itching skin or if you have trouble breathing after you receive hyaluronidase.

Amphadase Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare Cough difficulty swallowing dizziness fast heartbeat hives or welts itching large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs puffiness or swelling of the eyelids or around the eyes, face, lips or tongue redness of skin shortness of breath skin rash tightness in chest unusual tiredness or weakness wheezing Symptoms of Overdose

Get emergency help immediately if any of the following symptoms of overdose occur:

Blurred vision chills confusion dizziness dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly fast, pounding, or irregular heartbeat or pulse flushing nausea redness of skin swelling unusually warm skin sweating unusual tiredness or weakness vomiting

More common Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site Incidence not known Swelling

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Amphadase side effects (in more detail)

More Amphadase resources Amphadase Side Effects (in more detail)Amphadase Use in Pregnancy & BreastfeedingAmphadase Drug InteractionsAmphadase Support Group0 Reviews for Amphadase - Add your own review/rating Amphadase Prescribing Information (FDA) Amphadase Consumer Overview Amphadase MedFacts Consumer Leaflet (Wolters Kluwer) Hyaluronidase Professional Patient Advice (Wolters Kluwer) Hylenex Consumer Overview Hylenex MedFacts Consumer Leaflet (Wolters Kluwer) Vitrase Prescribing Information (FDA) Vitrase Consumer Overview Compare Amphadase with other medications ExtravasationHypodermoclysisSubcutaneous Urography

Aldactone

Generic Name: spironolactone (Oral route)

spir-on-oh-LAK-tone

Oral route(Tablet)

Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats. Spironolactone should be used only in those conditions specified as indications for use. Unnecessary use of this drug should be avoided .

Commonly used brand name(s)

In the U.S.

Aldactone

Available Dosage Forms:

Tablet

Therapeutic Class: Cardiovascular Agent

Pharmacologic Class: Aldosterone Receptor Antagonist

Uses For Aldactone

Spironolactone is used in combination with other medicines to treat high blood pressure (hypertension) and heart failure. It may also be used to treat water retention (edema) in patients with congestive heart failure, liver cirrhosis, or a kidney disorder called nephrotic syndrome.

Spironolactone is also used to diagnose and treat hyperaldosteronism, a condition in which the adrenal gland produces too much hormone called aldosterone.

Spironolactone is a type of a diuretic medicine (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. It can be used to prevent or treat hypokalemia (low potassium levels in the blood).

This medicine is available only with your doctor’s prescription.

Before Using Aldactone

Allergies

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of spironolactone in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of spironolactone in geriatric patients.

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Eplerenone Triamterene

Alacepril Arginine Arsenic Trioxide Benazepril Captopril Cilazapril Delapril Digoxin Droperidol Enalaprilat Enalapril Maleate Fosinopril Imidapril Levomethadyl Lisinopril Lithium Moexipril Pentopril Perindopril Potassium Quinapril Ramipril Sotalol Spirapril Tacrolimus Temocapril Trandolapril Zofenopril

Aceclofenac Acemetacin Alclofenac Apazone Benoxaprofen Bromfenac Bufexamac Carprofen Clometacin Clonixin Dexketoprofen Diclofenac Diflunisal Digitoxin Dipyrone Droxicam Etodolac Etofenamate Felbinac Fenbufen Fenoprofen Fentiazac Floctafenine Flufenamic Acid Flurbiprofen Gossypol Ibuprofen Indomethacin Indoprofen Isoxicam Ketoprofen Ketorolac Licorice Lornoxicam Meclofenamate Mefenamic Acid Meloxicam Nabumetone Naproxen Niflumic Acid Nimesulide Oxaprozin Oxyphenbutazone Phenylbutazone Pirazolac Piroxicam Pirprofen Propyphenazone Proquazone Sulindac Suprofen Tenidap Tenoxicam Tiaprofenic Acid Tolmetin Zomepirac Interactions with Food/Tobacco/Alcohol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Anuria (not able to pass urine) or Hyperkalemia (high potassium in the blood) or Kidney disease, severe—Should not be used in patients with these conditions. Electrolyte imbalance (e.g., low chloride, magnesium, potassium, or sodium in the body) or Fluid imbalances (caused by dehydration, vomiting, or diarrhea) or Liver disease, severe (e.g., cirrhosis)—Use with caution. May make these conditions worse. Proper Use of Aldactone

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt) and potassium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Dosing

For oral dosage form (tablets): For edema: Adults—At first, 100 milligrams (mg) per day, given in either single or divided doses. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For heart failure: Adults—At first, 25 milligrams (mg) per day. Your doctor may adjust your dose if needed and tolerated. Children—Use and dose must be determined by your doctor. For high blood pressure: Adults—At first, 50 to 100 milligrams (mg) per day, given in either single or divided doses. Your doctor may adjust your dose if needed. Children—Use and dose must be determined by your doctor. For low potassium in the blood: Adults—25 to 100 milligrams (mg) per day. Children—Use and dose must be determined by your doctor. For too much aldosterone in the body: Adults—400 milligrams (mg) for 4 days, or 400 mg per day for 3 to 4 weeks to diagnose the condition. Then, 100 to 400 mg per day after the diagnosis is confirmed. Children—Use and dose must be determined by your doctor. Missed Dose

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Aldactone

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.

Do not take other medicines unless they have been discussed with your doctor. This especially includes potassium supplements or salt substitutes containing potassium; or certain diuretics such as amiloride (Midamor®, Moduretic®), triamterene (Dyazide®, Dyrenium®, Maxzide®), or other products containing spironolactone (Aldactazide®).

This medicine may increase the amount of potassium in your blood (hyperkalemia). Stop using this medicine and check with your doctor right away if you are having abdominal or stomach pain; confusion; difficulty with breathing; irregular heartbeat; nausea or vomiting; nervousness; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs.

Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt.

Check with your doctor right away if you experience dizziness, fainting, confusion, muscle pain, weakness, and/or a fast heartbeat. Use extra care if you exercise or if the weather is hot. Heavy sweating can cause dehydration (loss of too much water) or electrolyte imbalances (loss of sodium, potassium, or magnesium in the body).

This medicine may cause swelling of the breasts (gynecomastia) and breast pain in some patients. If you have questions about this, talk to your doctor.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having medical tests. The results of some tests may be affected by this medicine.

This medicine may cause the formation of certain tumors in your body. Check with your doctor right away if you notice an unusual lump anywhere in your body or if you have any unusual signs or symptoms while you are using this medicine.

Aldactone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known Abdominal or stomach cramping, burning, or tenderness bloody or black, tarry stools bloody urine chills clay-colored stools clear or bloody discharge from the nipple cloudy urine constipation cough or hoarseness dark urine decrease in urine output or decrease in urine-concentrating ability decreased appetite diarrhea difficulty with swallowing dimpling of the breast skin dizziness fast heartbeat fever with or without chills general feeling of tiredness or weakness headache heartburn hives increased blood pressure increased thirst indigestion inverted nipple itching loss of appetite lower back or side pain lump in the breast or under the arm nausea and vomiting painful or difficult urination persistent crusting or scaling of the nipple puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue redness or swelling of the breast severe stomach pain shakiness and unsteady walk shortness of breath skin rash sore on the skin of the breast that does not heal sore throat sores, ulcers, or white spots on the lips or in the mouth swelling of the face, fingers, feet, or lower legs swollen, painful, or tender lymph glands in the neck, armpit, or groin tightness in the chest troubled breathing unpleasant breath odor unsteadiness, trembling, or other problems with muscle control or coordination unusual bleeding or bruising unusual tiredness or weakness vomiting of blood or material that looks like coffee grounds weight gain wheezing yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose Coma confusion convulsions difficulty with breathing drowsiness irregular heartbeat muscle pain or cramps nervousness numbness or tingling in the hands, feet, or lips rash with flat lesions or small raised lesions on the skin reddened skin swelling of the ankles or hands weakness or heaviness of the legs

Incidence not known Burning feeling in the chest or stomach sores, welting, or blisters stomach upset swelling of the breasts or breast soreness in both females and males unusual dullness or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Aldactone side effects (in more detail)

More Aldactone resources Aldactone Side Effects (in more detail)Aldactone DosageAldactone Use in Pregnancy & BreastfeedingDrug ImagesAldactone Drug InteractionsAldactone Support Group9 Reviews for Aldactone - Add your own review/rating Aldactone Prescribing Information (FDA) Aldactone Consumer Overview Aldactone Monograph (AHFS DI) Aldactone MedFacts Consumer Leaflet (Wolters Kluwer) Spironolactone Prescribing Information (FDA) Spironolactone Professional Patient Advice (Wolters Kluwer) Compare Aldactone with other medications AcneAlopeciaEdemaHeart FailureHigh Blood PressureHirsutismHypokalemiaPrimary HyperaldosteronismPrimary Hyperaldosteronism Diagnosis

incobotulinumtoxina Intramuscular

in-koe-bot-ue-LYE-num-tox-in-ay

Intramuscular route(Powder for Solution)

The effects of incobotulinumtoxinA and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity, but symptoms can also occur in adults, particularly in those patients who have underlying conditions that would predispose them to these symptoms. Cases of spread of effect have occurred at doses comparable to those used to treat cervical dystonia and at lower doses .

Commonly used brand name(s)

In the U.S.

Xeomin

Available Dosage Forms:

Powder for Solution

Pharmacologic Class: Botulinum Toxin Type A

Uses For incobotulinumtoxina

IncobotulinumtoxinA is used to treat the abnormal head position and neck pain that result from cervical dystonia (severe muscle spasms of the neck). incobotulinumtoxina is also used to treat certain eye condition called blepharospasm (a condition where the eyelid will not stay open because of a muscle spasm) in patients who have already been treated with onabotulinumtoxinA (Botox®). IncobotulinumtoxinA is also used cosmetically to improve the appearance of deep facial lines or wrinkles between the eyebrows (glabellar lines).

IncobotulinumtoxinA is a botulinum toxin A product. It works on the nervous system to relax the muscles.

incobotulinumtoxina is available only with your doctor's prescription and will be administered by your doctor.

Before Using incobotulinumtoxina

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For incobotulinumtoxina, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to incobotulinumtoxina or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of incobotulinumtoxinA in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of incobotulinumtoxinA in the elderly. However, elderly patients are more likely to have side effects such as difficulty with swallowing, lack or loss of strength, or dizziness, which may require caution in patients receiving incobotulinumtoxinA.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

The presence of other medical problems may affect the use of incobotulinumtoxina. Make sure you tell your doctor if you have any other medical problems, especially:

Amyotrophic lateral sclerosis (Lou Gehrig's disease) or Cornea or eye problems (e.g., ulcers) or Lambert-Eaton syndrome (nerve-muscle disorder) or Motor neuropathy (muscle and nerve problem) or Myasthenia gravis (severe muscle weakness)—May increase risk for more serious side effects. Breathing problems (e.g., asthma, emphysema) or Dysarthria (trouble with speaking) or Dysphagia (trouble with swallowing) or Dysphonia (voice problem) or Glaucoma, narrow angle or Ptosis (droopy eyelid) or Urinary incontinence (problems passing urine)—Use with caution. May make these conditions worse. Infection at the injection site—Should not be used in patients with this condition. Proper Use of incobotulinumtoxina

Your doctor will give you incobotulinumtoxina in a hospital or clinic setting. incobotulinumtoxina is given as a shot into one of your muscles.

incobotulinumtoxina should come with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Your doctor will only use incobotulinumtoxinA (Xeomin®) to treat your condition. Other botulinum toxin products may not work the same way.

Precautions While Using incobotulinumtoxina

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

Serious muscle reactions have been reported within hours to weeks after receiving incobotulinumtoxina. If you start to have muscle weakness, loss of bladder control, or trouble with swallowing, talking, or breathing, call your doctor right away. In some situations, these problems could be life-threatening and may require treatment in a hospital or clinic.

incobotulinumtoxina may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using incobotulinumtoxina.

incobotulinumtoxina may make your muscles weak and cause vision problems. Avoid driving, using machines, or doing anything else that could be dangerous if you feel weak or are not able to see well.

incobotulinumtoxina may reduce blinking of the eye which can lead to an increased risk of eye problems (such as corneal exposure and ulcers). Tell your doctor right away if you have a reduced blinking of the eye.

After you have received incobotulinumtoxina and your vision or muscle spasms are better, you may find that you are a lot more active than you were before. You should slowly increase your activities to allow time for your body to get stronger. Also, before you start an exercise program, check with your doctor.

One part of incobotulinumtoxina is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made of human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during the manufacture of these medicines. Although the risk is low, talk with your doctor if you have concerns.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

incobotulinumtoxina Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common—for cervical dystonia Difficulty with swallowing muscle or bone pain muscle weakness pain in the neck More common—for blepharospasm Dry eyes Rare—for glabellar lines Itching, pain, redness, or swelling at the injection site pain in the face swelling of the eyelids Incidence not known Changes in patterns and rhythms of speech fast heartbeat fever hives hoarseness irritation itching joint pain, stiffness, or swelling muscle spasm pain at the injection site rash redness of the skin shortness of breath slurred speech swelling of the eyes or eyelids swelling of the face, lips, hands, or feet tightness in the chest trouble with speaking troubled breathing or swallowing wheezing

More common—for cervical dystonia Chills cough lower back or side pain painful or difficult urination More common—for blepharospasm Blurred vision diarrhea drooping upper eyelids dry mouth headache Less common—for blepharospasm Difficult or labored breathing muscle aches sneezing sore throat stuffy or runny nose unusual tiredness or weakness Rare—for glabellar lines Drooping of the eyelids increased blinking twitching of the eyelids Incidence not known Difficulty with moving joint pain muscle aching or cramping muscle pains or stiffness nausea painful blisters on the trunk of the body swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: incobotulinumtoxina Intramuscular side effects (in more detail)

More incobotulinumtoxina Intramuscular resources Incobotulinumtoxina Intramuscular Side Effects (in more detail)Incobotulinumtoxina Intramuscular Use in Pregnancy & BreastfeedingIncobotulinumtoxina Intramuscular Drug InteractionsIncobotulinumtoxina Intramuscular Support Group0 Reviews for Incobotulinumtoxina Intramuscular - Add your own review/rating Compare incobotulinumtoxina Intramuscular with other medications BlepharospasmCervical DystoniaFacial Wrinkles

Hydromol Emollient
1. Name Of The Medicinal Product

HYDROMOL EMOLLIENT

2. Qualitative And Quantitative Composition

Light Liquid Paraffin BP 37.80% w/w

Isopropyl Myristate BP 13.00% w/w

3. Pharmaceutical Form

Hydromol Emollient is a clear, colourless bath additive.

4. Clinical Particulars 4.1 Therapeutic Indications

For the treatment of dry skin conditions such as eczema, ichthyosis and senile pruritus.

4.2 Posology And Method Of Administration

Route of administration

Hydromol Emollient should be used topically and is either added to water or applied to wet skin.

1. For use in the bath

a) Adults/Children and the Elderly:

Add 1–3 capfuls to an 8 inch bath of water. Soak for 10-15 minutes.

b) Infants:

Add ? to 2 capfuls to a small bath of water.

2. For application to the skin as a sponge bath or in the shower.

Adults and Children and the Elderly:

Pour a small quantity on to a wet sponge or flannel and rub onto wet skin. Rinse and pat dry.

4.3 Contraindications

Known sensitivity to any of the ingredients.

4.4 Special Warnings And Precautions For Use

Keep away from eyes. Take care to avoid slipping in the bath/shower. If there is aggravation of the condition consult the doctor.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None known.

4.6 Pregnancy And Lactation

Hydromol Emollient is not contra-indicated in pregnancy or lactation.

4.7 Effects On Ability To Drive And Use Machines

Not applicable.

4.8 Undesirable Effects

Patients should be advised to take care to avoid slipping in the bath.

4.9 Overdose

Not applicable. Hydromol Emollient is for topical use only.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

The combination of oils used in Hydromol Emollient are deposited on the skin surface during bathing and thus reduce moisture loss, provide anti-pruritic action, lubricate and soften the skin.

Hydromol Emollient is particularly suitable for infant bathing. The preparation can also be used as a cleanser where soaps are best avoided.

5.2 Pharmacokinetic Properties

Hydromol Emollient is a water-dispersible bath additive resulting in an emulsion of dispersed oils together with an homogenised film on the surface.

5.3 Preclinical Safety Data

None stated.

6. Pharmaceutical Particulars 6.1 List Of Excipients

C12-C14 Alcohol with 3 molecules of Ethylene Oxide, Polyol Fatty Acid Ester, Iso-octyl Stearate.

6.2 Incompatibilities

Not applicable. Hydromol Emollient is for topical use only.

6.3 Shelf Life

3 years.

6.4 Special Precautions For Storage

Hydromol Emollient should be stored in a dry place avoiding extremes of temperature ie above 30°C or below 5°C.

6.5 Nature And Contents Of Container

Hydromol Emollient is packed in printed polyethylene bottles of 25 ml, 150 ml, 200 ml, 350 ml and 1 litre capacity.

6.6 Special Precautions For Disposal And Other Handling

Hydromol Emollient should be used topically and is either added to water or applied to wet skin.

1. For use in the bath

a) Adults/Children and the Elderly:

Add 1–3 capfuls to an 8 inch bath of water. Soak for 10-15 minutes.

b) Infants:

Add ? to 2 capfuls to a small bath of water.

2. For application to the skin as a sponge bath or in the shower.

Adults and Children and the Elderly:

Pour a small quantity on to a wet sponge or flannel and rub onto wet skin. Rinse and pat dry.

7. Marketing Authorisation Holder

Adams Healthcare

Lotherton Way

Garforth

Leeds LS25 2JY

United Kingdom

8. Marketing Authorisation Number(S)

PL 16108/0043

9. Date Of First Authorisation/Renewal Of The Authorisation

31 August 2001

10. Date Of Revision Of The Text

methyl aminolevulinate topical

Generic Name: methyl aminolevulinate (topical) (METH il a MEE noe LEV ue LIN ate) Brand Names: Metvixia

What is methyl aminolevulinate?

Methyl aminolevulinate makes your skin more sensitive to light. It works by causing a reaction with light that can destroy certain types of diseased skin cells.

Methyl aminolevulinate topical (for the skin) is used in combination with red light therapy to treat a skin condition called actinic keratosis of the face and scalp.

Methyl aminolevulinate may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about methyl aminolevulinate? You should not use this medication if you are allergic to methyl aminolevulinate, porphyrins, peanuts or almonds, or if your skin is especially sensitive to light.

Before you are treated with methyl aminolevulinate, tell your doctor about all of your medical conditions. Also tell your doctor about all other medications you use, especially drugs that can make your skin more sensitive to sunlight, such as certain antibiotics, heart or blood pressure medications, diuretics (water pills), sulfa drugs, oral diabetes medications, or NSAID pain or arthritis medicines.

Methyl aminolevulinate is applied by a healthcare provider in a clinic setting. For at least 48 hours after your treatment, avoid exposing treated skin to sunlight, sunlamps, tanning beds, or other bright lights. Sunscreen is not effective enough to protect treated skin from harm caused by bring light during this time. Wear protective clothing whenever you are outdoors. Call your doctor at once if you have severe stinging, burning, redness, oozing, or swelling of treated skin areas, especially if you have these effects for longer than 3 weeks after treatment.

It may take several weeks before you notice improvement in your skin condition. Your doctor will need to check your treated skin 3 months after the end of your last treatment with methyl aminolevulinate.

Your skin lesions may need to be treated more than once, and they may come back after treatment. Talk to your doctor about the number of treatments needed to treat your condition. What should I discuss with my health care provider before taking methyl aminolevulinate? You should not use this medication if you are allergic to methyl aminolevulinate, or if you have:

an allergy to peanuts or almonds;

an allergy to porphyrins; or

if your skin is especially sensitive to light.

Before you are treated with methyl aminolevulinate, tell your doctor about all of your medical conditions.

FDA pregnancy category C. It is not known whether methyl aminolevulinate is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether methyl aminolevulinate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How is methyl aminolevulinate used?

Methyl aminolevulinate topical is a cream that is applied to actinic keratosis skin lesions prior to red light treatment. Your doctor, nurse, or other healthcare provider will prepare your skin and apply this medication in a clinic setting.

Prior to application of methyl aminolevulinate, your skin lesions will be gently scraped to remove any scales or crusting. After the medication is applied, your caregiver will cover the treatment area with a bandage. You will need to leave this bandage in place for 3 hours.

During this 3-hour period, avoid exposure to cold temperatures and sunlight or bright indoor lights. Wear a wide-brimmed hat if you must be outdoors during this time.

After your bandaging is removed, any excess medication will be removed with a saline solution. You will then be ready to receive the light treatment.

You will be given eye-wear to protect your eyes during red light treatment.

You may feel a slight stinging or burning during light therapy. Tell your caregivers if you have any type of severe discomfort.

Methyl aminolevulinate and red light therapy is usually given in two sessions one week apart. Your treatment schedule may be different. Follow your doctor's instructions.

Since methyl aminolevulinate is applied only when needed prior to red light therapy, you will not be on a dosing schedule.

What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a methyl aminolevulinate overdose are not known.

What should I avoid while taking methyl aminolevulinate? Tell your caregivers right away if any of this medication gets into your eyes, mouth, or nose. Avoid touching the treated skin areas after methyl aminolevulinate cream has been applied to them. Special gloves must be worn by the healthcare provider while applying this medication, and you should not allow your own fingers to come into contact with the cream on your skin. For at least 48 hours after your treatment, avoid exposing treated skin to sunlight, sunlamps, tanning beds, or other bright lights. Sunscreen is not effective enough to protect treated skin from harm caused by bring light during this time. Wear protective clothing whenever you are outdoors.

Even if you do not receive the light therapy portion of your treatment, you must still protect your skin from light for 48 hours after the cream was applied.

Methyl aminolevulinate side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have severe stinging, burning, redness, oozing, or swelling of treated skin areas, especially if you have these effects for longer than 3 weeks after treatment.

Less serious side effects may include:

mild skin redness, warmth, burning, or swelling;

puffy eyes;

slight pain; or

itching, peeling, scabs or crusting of treated skin.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.

Methyl aminolevulinate Dosing Information

Usual Adult Dose for Keratosis:

Non-hyperkeratotic, nonpigmented actinic keratoses of the face and scalp in immunocompetent patients: Apply directly on lesion(s), up to a total of 1 gram (half tube) per each treatment session. Two sessions one week apart should be administered. Cream application should be followed by photoactivation with Aktilite CL 128 lamp red light illumination.Prior to cream application, a small dermal curette should be used to remove scales and crusts and to roughen the surface of the lesion(s). An approximately 1 mm-thick layer of cream should be applied with a spatula to each lesion and the surrounding 5 mm of normal skin. The application area should then be covered with an occlusive, nonabsorbent dressing for 3 hours (2.5 to 4 hours). Multiple lesions may be treated during the same session, up to an area of 80 X 180 mm (the area of illumination).

AquADEKs Drops
Pronunciation: muhl-tee-VYE-ta-min/MIN-er-alsGeneric Name: MultivitaminBrand Name: AquADEKs

Amprenavir Solution
Pronunciation: am-PREN-ah-veerGeneric Name: AmprenavirBrand Name: Agenerase

immune globulin subcutaneous

Generic Name: immune globulin (subcutaneous) (im MYOON GLOB yoo lin (sub koo TANE ee us)) Brand Names: Hizentra, Vivaglobin

What is immune globulin?

Immune globulin is a sterilized solution made from human plasma. It contains the antibodies to help your body protect itself against infection from various diseases.

Immune globulin subcutaneous (for injection under the skin) is used to treat primary immune deficiency.

Immune globulin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about immune globulin? You should not use this medication if you have ever had an allergic reaction to an immune globulin, if you have immune globulin A (IgA) deficiency with antibody to IgA, or if you have a condition called hyperprolinemia (high level of a certain amino acid in the blood).

Before using this medication, tell your doctor if you have blood circulation problems or a blood vessel disorder, a history of stroke or blood clot, or if you have been bed-ridden due to severe illness.

Immune globulin is usually given once every week. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, tubing, and other items used to inject the medicine.

Subcutaneous immune globulin is for injection only under the skin. Do not inject this medicine into a vein.

If you use this medication at home, keep a diary of the days and times you used the medication and where you injected it on your body.

You may need a dose adjustment if you are exposed to measles, or if you travel to an area where this disease is common. What should I discuss with my health care provider before using immune globulin? You should not use this medication if you have ever had an allergic reaction to an immune globulin, if you have immune globulin A (IgA) deficiency with antibody to IgA, or if you have a condition called hyperprolinemia (high level of a certain amino acid in the blood). You may need a dose adjustment if you are exposed to measles, or if you travel to an area where this disease is common.

If you have any of these other conditions, you may need a dose adjustment or special tests:

blood circulation problems or a blood vessel disorder;

a history of stroke or blood clot; or

if you have been bed-ridden due to severe illness.

You may need a dose adjustment if you are exposed to measles, or if you travel to an area where this disease is common. FDA pregnancy category C. It is not known whether immune globulin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether immune globulin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Immune globulin is made from human plasma (part of the blood) which may contain viruses and other infectious agents. Donated plasma is tested and treated to reduce the risk of it containing infectious agents, but there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

How is immune globulin given?

Immune globulin subcutaneous is given as an injection using an infusion pump. The medicine enters the body through a needle or catheter placed under your skin. The catheter is attached to the pump with an infusion tube.

You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, tubing, and other items used to inject the medicine.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Immune globulin must be given slowly, and the infusion can take about 1 hour to complete. You may need to use up to 4 catheters to inject this medicine into different body areas at the same time. Your care provider will show you the best places on your body to inject the medication. Follow your doctor's instructions.

Subcutaneous immune globulin is for injection only under the skin. Do not inject this medicine into a vein. Before injecting the medicine, test to make sure the needle is not in a vein. To do this, gently pull back on the plunger of the syringe connected to the infusion tube. If blood flows back into the syringe, remove the catheter and tubing and throw them away. Start over with a new catheter and syringe, insert the needle in a new place on your body, and test for blood flow-back again.

Immune globulin is usually given once every week. Follow your doctor's dosing instructions. If you use this medication at home, keep a diary of the days and times you gave the injection and where you injected it on your body.

Do not shake the medication bottle or you may ruin the medicine. Prepare your dose only when you are ready to give yourself an injection. Do not mix immune globulin with other medications in the same infusion. Do not use the medication if it has changed colors, looks cloudy, or has particles in it. Call your doctor for a new prescription.

Use disposable injection items (needle, catheter, tubing) only once. Throw away the used items in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

To be sure this medication is helping your condition, your blood may need to be tested often. Visit your doctor regularly.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using immune globulin.

Each single use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Store Hizentra in the original carton at room temperature, away from moisture, heat, and light. Do not freeze. Store Vivaglobin in its original carton in the refrigerator. Do not freeze. Take the medicine out and allow it to reach room temperature before preparing your dose.

Throw away any immune globulin that has become frozen. Throw away any unused medication after the expiration date on the label has passed.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while using immune globulin? Do not receive a "live" vaccine while using immune globulin The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), oral polio, chickenpox (varicella), BCG (Bacillus Calmette and Gu?rin), and nasal flu vaccine. Immune globulin side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; wheezing, difficulty breathing; dizziness, feeling like you might pass out; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

swelling, rapid weight gain, feeling short of breath, urinating less than usual or not at all;

pain, swelling, redness, warmth, or a lump in your arms or legs;

pale or yellowed skin, dark colored urine, fast heart rate;

fever, severe headache, sore throat, neck stiffness, chills, increased sensitivity to light, confusion, and general ill feeling;

chest pain or tightness, trouble breathing; or

signs of new infection such as high fever, chills, body aches, flu symptoms, or sores in your mouth and throat.

Less serious side effects may include:

pain, redness, warmth, itching, and swelling of skin where the injection was given;

nausea, vomiting, diarrhea, stomach pain;

headache;

mild skin rash;

back pain;

joint or muscle pain; or

tired feeling;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Immune globulin Dosing Information

Usual Adult Dose for Primary Immunodeficiency Syndrome:

Begin treatment one week after receiving a regularly scheduled IGIV infusion. Initial dose: calculated by multiplying the previous IGIV dose by 1.37, then dividing this dose into weekly doses based on the patient's previous IGIV treatment, administered subcutaneously; for example, if IGIV was administered every three weeks, divide by 3.

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