Alprazolam Intensol Solution
Pronunciation: al-PRA-zoe-lamGeneric Name: AlprazolamBrand Name: Alprazolam Intensol

Cordran Cream
Pronunciation: FLUR-an-DREN-oh-lideGeneric Name: FlurandrenolideBrand Name: Examples include Cordran SP and Cordran

fosaprepitant Intravenous

fos-a-PRE-pi-tant dye-MEG-loo-meen

Commonly used brand name(s)

In the U.S.

Emend

Available Dosage Forms:

Powder for Solution

Therapeutic Class: Antiemetic

Pharmacologic Class: Fosaprepitant

Uses For fosaprepitant

Fosaprepitant is used with other medicines to prevent nausea and vomiting caused by cancer treatment (chemotherapy). It acts in the brain to prevent nausea.

fosaprepitant is available only with your doctor's prescription.

Before Using fosaprepitant

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For fosaprepitant, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to fosaprepitant or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of fosaprepitant in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fosaprepitant in the elderly.

Pregnancy Pregnancy Category Explanation All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving fosaprepitant, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using fosaprepitant with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Astemizole Cisapride Pimozide Terfenadine

Using fosaprepitant with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Etoposide Ifosfamide Imatinib Irinotecan Paclitaxel Vinblastine Vincristine

Using fosaprepitant with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Alprazolam Desogestrel Dexamethasone Dienogest Diltiazem Drospirenone Estradiol Cypionate Estradiol Valerate Ethinyl Estradiol Ethynodiol Diacetate Etonogestrel Ketoconazole Levonorgestrel Medroxyprogesterone Acetate Mestranol Midazolam Norelgestromin Norethindrone Norgestimate Norgestrel Rifampin Tolbutamide Triazolam Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of fosaprepitant

A nurse or other trained health professional will give you fosaprepitant in a hospital or clinic. fosaprepitant is given through a needle placed in one of your veins.

fosaprepitant is usually given on the first day of your chemotherapy as part of a three-day regimen along with other medicines. Fosaprepitant is not for long-term use, but you may need to use fosaprepitant again if you have more chemotherapy in the future.

fosaprepitant comes with a patient information insert. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Precautions While Using fosaprepitant

It is very important that your doctor check your progress at regular visits to make sure fosaprepitant is working properly and to check for unwanted effects.

You should not receive fosaprepitant if you are also using cisapride (Propulsid®) or pimozide (Orap®). Fosaprepitant may cause serious or life-threatening problems if used together with these medicines.

fosaprepitant may cause serious allergic reactions. Tell your doctor or nurse right away if you have itching; hives; a rash; shortness of breath; trouble with breathing; trouble with swallowing; warmth or redness in your face, neck, arms, or upper chest; or any swelling of your hands, face, or mouth while you are receiving fosaprepitant.

If you are also taking a blood thinner called warfarin (Coumadin®, Jantoven®), your doctor will need to check your blood after using fosaprepitant.

Birth control pills may not work as well while you are using fosaprepitant. To keep from getting pregnant, use another form of birth control together with your pills during treatment and for one month after your last treatment. Other forms include condoms, diaphragms, and contraceptive foams or jellies.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

fosaprepitant Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common Black, tarry stools blurred vision chills confusion cough decreased urination difficult or labored breathing dizziness dry mouth fainting fever increase in heart rate lightheadedness lower back or side pain nervousness pain, swelling, or redness at the injection site painful or difficult urination pale skin pounding in the ears rapid breathing shortness of breath slow or fast heartbeat sore throat sunken eyes tenderness, swelling, warmth, or skin discoloration at the injection site thirst tightness in the chest ulcers, sores, or white spots in mouth unusual bleeding or bruising unusual tiredness or weakness wheezing wrinkled skin Less common Hard lump at the injection site Rare Blood in the urine changes in patterns and rhythms of speech changes in skin color chest pain or discomfort coma convulsions fast, slow, irregular, pounding, or racing heartbeat or pulse general feeling of discomfort or illness headache increased sweating increased thirst lightheadedness, dizziness, or fainting muscle pain or cramps nausea or vomiting pain, tenderness, or swelling of the foot or leg slurred speech swelling swelling of the face, ankles, or hands trouble with speaking troubled breathing with exertion wheezing Incidence not known Difficulty with swallowing hives or welts itching large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue redness of the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Acid or sour stomach belching burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings continuing ringing or buzzing or other unexplained noise in ears diarrhea difficulty having a bowel movement (stool) dizziness feeling of indigestion hair loss or thinning of the hair hearing loss hiccups indigestion lack or loss of strength loss of appetite pain in the chest below the breastbone stomach discomfort, upset, or pain swelling or inflammation of the mouth weight loss Less common Feeling of warmth pain or discomfort in chest, upper stomach, or throat redness of the face, neck, arms, and occasionally, upper chest sudden sweating unusually warm skin Rare Abdominal or stomach distension or pain abnormal dreams blemishes on the skin bumps on the skin burning, dry, or itching eyes change in taste change in walking and balance clumsiness or unsteadiness confusion about identity, place, and time difficulty with moving discharge, excessive tearing excess air or gas in the stomach extreme thirst false or unusual sense of well-being flushed, dry skin frequent urination fruit-like breath odor full feeling heartburn increased hunger increased sensitivity of the skin to sunlight increased urination increased volume of pale, dilute urine joint pain muscle aching or cramping muscle stiffness or weakness oily skin passing gas pimples redness or other discoloration of the skin redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid severe constipation severe sunburn sleepiness sleeplessness sweating swollen joints trouble performing routine tasks trouble sleeping unable to sleep unexplained weight loss unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness weight gain white patches in the mouth or throat or on the tongue white patches with diaper rash

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: fosaprepitant Intravenous side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More fosaprepitant Intravenous resources Fosaprepitant Intravenous Side Effects (in more detail)Fosaprepitant Intravenous Use in Pregnancy & BreastfeedingFosaprepitant Intravenous Drug InteractionsFosaprepitant Intravenous Support Group0 Reviews for Fosaprepitant Intravenous - Add your own review/rating Compare fosaprepitant Intravenous with other medications Nausea/Vomiting, Chemotherapy Induced

Acutrim 16 Hour

Generic Name: phenylpropanolamine (fen ill proe pa NOLE a meen) Brand Names: Acutrim 16 Hour, Acutrim II, Maximum Strength, Acutrim Late Day, Control, Dexatrim, Empro, Mega-Trim, Phenyldrine, Propagest, Propan, Rhindecon, Westrim, Westrim LA

What is Acutrim 16 Hour (phenylpropanolamine)?

Phenylpropanolamine is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in your body. Constriction of blood vessels in your sinuses, nose, and chest allows drainage of those areas, which decreases congestion.

Phenylpropanolamine is used to treat the congestion associated with allergies, hay fever, sinus irritation, and the common cold. Phenylpropanolamine also causes a decrease in appetite and is used in some over-the-counter diet aids.

Phenylpropanolamine has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Phenylpropanolamine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Acutrim 16 Hour (phenylpropanolamine)?

Phenylpropanolamine has been associated with an increased risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food and Drug Administration (FDA) recommends that consumers not use any products that contain phenylpropanolamine.

Do not take phenylpropanolamine for longer than 7 days if your condition does not improve or if your symptoms are accompanied by a high fever.

Do not take more of this medication than is recommended on the package or by your doctor. Use caution when driving, operating machinery, or performing other hazardous activities. Phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Who should not take Acutrim 16 Hour (phenylpropanolamine)?

Do not take phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have

high blood pressure;

any type of heart disease, hardening of the arteries, or irregular heartbeat;

thyroid problems;

diabetes;

glaucoma or increased pressure in your eye;

an enlarged prostate or difficulty urinating; or

liver or kidney disease.

You may not be able to take phenylpropanolamine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether phenylpropanolamine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. Infants are especially sensitive to the effects of phenylpropanolamine. Do not take this drug if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from phenylpropanolamine. You may require a lower dose of this medication. Using a short-acting formulation of phenylpropanolamine (not a long-acting or a controlled-release formulation) may be safer if you are over 60 years of age. How should I take Acutrim 16 Hour (phenylpropanolamine)?

Take phenylpropanolamine exactly as directed by your doctor, or follow the instructions that accompany the package. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Never take this medication in larger doses or more often than is recommended. Too much phenylpropanolamine could be very harmful.

If your symptoms are accompanied by a high fever, or if they do not improve in 7 days, see your doctor.

Store phenylpropanolamine at room temperature away from moisture and heat. What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose? Seek emergency medical attention.

Symptoms of a phenylpropanolamine overdose include extreme tiredness, sweating, dizziness, a slow heart beat, and a coma.

What should I avoid while taking Acutrim 16 Hour (phenylpropanolamine)? Use caution when driving, operating machinery, or performing other hazardous activities. Phenylpropanolamine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Never take this medication in larger doses or more often than is recommended. Too much phenylpropanolamine could be very harmful. Acutrim 16 Hour (phenylpropanolamine) side effects

If you experience any of the following serious side effects from this medication, stop taking phenylpropanolamine and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

seizures;

unusual behavior or hallucinations; or

an irregular or fast heartbeat.

Other, less serious side effects may be more likely to occur. Continue to take phenylpropanolamine and talk to your doctor if you experience

dizziness, lightheadedness, or drowsiness;

headache;

insomnia;

anxiety;

tremor (shaking) or restlessness;

nausea or vomiting; or

sweating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Acutrim 16 Hour (phenylpropanolamine)?

Do not take phenylpropanolamine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

Phenylpropanolamine may also interact with the following medicines:

furazolidone (Furoxone);

guanethidine (Ismelin);

indomethacin (Indocin);

methyldopa (Aldomet);

bromocriptine (Parlodel);

caffeine in cola, tea, coffee, chocolate, and other products;

theophylline (Theo-Dur, Theochron, Theolair, others);

tricyclic antidepressants such as amitriptyline (Elavil, Endep), doxepin (Sinequan), and nortriptyline (Pamelor); other commonly used tricyclic antidepressants, including amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Tofranil), protriptyline (Vivactil), and trimipramine (Surmontil); phenothiazines such as chlorpromazine (Thorazine), thioridazine (Mellaril), and prochlorperazine (Compazine); and other commonly used phenothiazines, including fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), and trifluoperazine (Stelazine).

Drugs other than those listed here may also interact with phenylpropanolamine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

More Acutrim 16 Hour resources Acutrim 16 Hour Side Effects (in more detail)Acutrim 16 Hour Use in Pregnancy & BreastfeedingAcutrim 16 Hour Drug InteractionsAcutrim 16 Hour Support Group0 Reviews for Acutrim6 Hour - Add your own review/rating Propantheline Bromide Monograph (AHFS DI) Compare Acutrim 16 Hour with other medications Nasal CongestionWeight Loss Where can I get more information? Your pharmacist has more information about phenylpropanolamine written for health professionals that you may read. What does my medication look like?

Phenylpropanolamine is available over the counter under the brand name Propagest, and with a prescription under the brand name Rhindecon. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Propagest 25 mg--oval, white, scored tablets

Rhindecon 75 mg--timed-release capsules

See also: Acutrim6 Hour side effects (in more detail)

Tositumomab

Class: Antineoplastic AgentsVA Class: AN600CAS Number: 192391-48-3

Melphalan Tablets
Pronunciation: MEL-fa-lanGeneric Name: MelphalanBrand Name: Alkeran

Glucagon
Pronunciation: GLOO-ka-gonGeneric Name: GlucagonBrand Name: GlucaGen

Chlorthalidone/Clonidine
Pronunciation: klor-THAL-i-done/KLON-i-deenGeneric Name: Chlorthalidone/ClonidineBrand Name: Clorpres

Onyx Pharmaceuticals, Inc
Address Onyx Pharmaceuticals, Inc, 2100 Powell Street Emeryville, CA 94608Contact DetailsPhone: (510) 597-6500

Capoten

Generic Name: captopril (KAP toe pril) Brand Names: Capoten

What is captopril?

Captopril is an ACE inhibitor. ACE stands for angiotensin converting enzyme.

Captopril is used to treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by diabetes, and to improve survival after a heart attack.

Captopril may also be used for purposes not listed in this medication guide.

What is the most important information I should know about captopril? Do not use captopril if you are pregnant. Captopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Drinking alcohol can further lower your blood pressure and may increase certain side effects of captopril. Do not use salt substitutes or potassium supplements while taking captopril, unless your doctor has told you to.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking captopril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

What should I discuss with my healthcare provider before taking captopril? You should not use this medication if you are allergic to captopril or to any other ACE inhibitor, such as benazepril (Lotensin), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).

To make sure you can safely take captopril, tell your doctor if you have any of these other conditions:

kidney disease (or if you are on dialysis);

liver disease;

heart disease or congestive heart failure;

diabetes; or

a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis.

FDA pregnancy category D. Do not use captopril if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Captopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking captopril. Captopril can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using captopril. How should I take captopril?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Captopril is usually taken 1 hour before meals. Follow your doctor's instructions.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking captopril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Your blood pressure will need to be checked often. Your kidney or liver function may also need to be tested. Visit your doctor regularly.

If you need surgery, tell the surgeon ahead of time that you are using captopril. You may need to stop using the medicine for a short time.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

See also: Capoten dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling extremely dizzy or light-headed, or fainting.

What should I avoid while taking captopril? Drinking alcohol can further lower your blood pressure and may increase certain side effects of captopril. Do not use salt substitutes or potassium supplements while taking captopril, unless your doctor has told you to. Captopril side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

feeling light-headed, fainting;

urinating more or less than usual, or not at all;

fever, chills, body aches, flu symptoms;

pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;

easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

fast, pounding, or uneven heartbeats;

chest pain; or

swelling, rapid weight gain.

Less serious side effects may include:

cough;

loss of taste sensation, loss of appetite;

dizziness, drowsiness, headache;

sleep problems (insomnia);

dry mouth, sores inside your mouth or on your lips;

nausea, diarrhea, constipation; or

mild skin itching or rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect captopril?

Tell your doctor about all other medicines you use, especially:

gold injections to treat arthritis;

lithium (Lithobid, Eskalith);

a potassium supplement such as K-Dur, Klor-Con;

salt substitutes that contain potassium;

drugs that can dilate blood vessels, such as alprostadil (Caverject, Edex), nitroglycerin (Nitro Dur, Nitrolingual, Nitrostat, Transderm Nitro, and others), nitroprusside (Nitropress), nesiritide (Natrecor), minoxidil (Loniten), or isosorbide dinitrate (Imdur, Isordil);

aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others; or

a diuretic (water pill).

This list is not complete and other drugs may interact with captopril. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Capoten resources Capoten Side Effects (in more detail)Capoten DosageCapoten Use in Pregnancy & BreastfeedingDrug ImagesCapoten Drug InteractionsCapoten Support Group0 Reviews for Capoten - Add your own review/rating Capoten Prescribing Information (FDA) Capoten Monograph (AHFS DI) Capoten Advanced Consumer (Micromedex) - Includes Dosage Information Capoten Consumer Overview Capoten MedFacts Consumer Leaflet (Wolters Kluwer) Captopril Professional Patient Advice (Wolters Kluwer) Compare Capoten with other medications CystinuriaDiabetic Kidney DiseaseHeart FailureHigh Blood PressureHypertensive EmergencyLeft Ventricular Dysfunction Where can I get more information? Your pharmacist can provide more information about captopril.

See also: Capoten side effects (in more detail)

IsoDitrate
isosorbide dinitrate Dosage Form: tablet, extended releaseIsoDitrate® E.R. Tablets

Geref Diagnostic

Generic Name: sermorelin (Injection route)

ser-moe-REL-in

Commonly used brand name(s)

In the U.S.

Geref Geref Diagnostic

Available Dosage Forms:

Powder for Solution

Therapeutic Class: Endocrine-Metabolic Agent

Pharmacologic Class: Growth Hormone Releasing Hormone Analog

Uses For Geref Diagnostic

Sermorelin is a synthetic (man-made) version of a naturally occurring substance that causes release of growth hormone from the pituitary gland. Growth hormone is naturally produced by the pituitary gland and is necessary for growth in children. In children who fail to grow normally because their bodies are not producing enough growth hormone, this medicine may be used to increase the amount of growth hormone produced by the pituitary gland.

This medicine is available only with your doctor's prescription.

Before Using Geref Diagnostic

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Underactive thyroid—This condition can interfere with the effects of sermorelin Proper Use of sermorelin

This section provides information on the proper use of a number of products that contain sermorelin. It may not be specific to Geref Diagnostic. Please read with care.

If you are injecting this medicine yourself, use it exactly as directed by your doctor. Do not use more or less of it, and do not use it more often than your doctor ordered. The exact amount of medicine needed has been carefully worked out. Using too much will increase the risk of side effects, while using too little may not improve the condition.

Each package of sermorelin contains a patient instruction sheet. Read this sheet carefully and make sure you understand:

How to prepare the injection. Proper use of disposable syringes and needles, including safe handling and disposal. How to give the injection. How long the injection is safe to use.

It is best to use a different place on the body for each injection (for example, abdomen, hip, thigh, or upper arm). To help you remember to do this, you may want to keep a record of the date and location for each injection.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Storage

Store in the refrigerator. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Geref Diagnostic

It is very important that your doctor check your progress at regular visits.

Geref Diagnostic Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common Pain, redness, or swelling at the place of injection Rare Itching trouble in swallowing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Rare Dizziness flushing headache sleepiness trouble sitting still

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Geref Diagnostic resources Geref Diagnostic Use in Pregnancy & BreastfeedingGeref Diagnostic Support Group0 Reviews · Be the first to review/rate this drug Geref MedFacts Consumer Leaflet (Wolters Kluwer)

Loratadine Drug Facts
Dosage Form: tabletDrug Facts Active Ingredient (in each tablet)

Loratadine, USP 10 mg

Purpose

Antihistamine

Uses

Temporarily relieves these symptoms due to hay fever or other upper respiratory allergies:

runny nose itchy, watery eyes sneezing itching of the nose or throat Warnings Do not use

if you have ever had an allergic reaction to this product or any of its ingredients.

Ask a doctor before use if you have

liver or kidney disease.Your doctor should determine if you need a different dose.

When using this product

do not take more than directed. Taking more than directed may cause drowsiness.

Stop use and ask a doctor

if an allergic reaction to this product occurs. Seek medical help right away.

If pregnant or breast-feeding,

ask a health professional before use.

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away.

Directions adults and children 6 years and over 1 tablet daily; not more than 1 tablet in 24 hours children under 6 years of age ask a doctor consumers with liver or kidney disease ask a doctor Other Information Safety sealed: do not use if the imprinted bottle seal is open or torn (for bottle only). Safety sealed: do not use if open or torn (for blister package only). Store at 20°-25°C (68°-77°F) (see USP Controlled Room Temperature). Inactive Ingredients

Lactose monohydrate, magnesium stearate, microcrystalline cellulose and sodium starch glycolate.

Questions or comments?

1-800-525-8747

05-2010M

Sandoz Inc.

Princeton, NJ 08540

mg Label

NDC 0781-5077-01 Non-Drowsy*

LORAtadine

Tablets, USP

10 mg

Antihistamine

Indoor & Outdoor Allergies

100 Tablets

SANDOZ

24 Hour

Relief of:

Sneezing

Runny Nose

Itchy, Watery

Eyes

Itchy Throat

or Nose

* When taken as directed.

See Drug Facts Panel.

mg Blister Pack

NDC 0781-5077-64

LORAtadine Tablets, USP 10 mg

10-2009M

Stemetic

Generic Name: trimethobenzamide (Intramuscular route)

trye-meth-oh-BENZ-a-mide

Commonly used brand name(s)

In the U.S.

Arrestin Benzacot Stemetic Ticon Tigan Tribenzagan

Available Dosage Forms:

Solution

Therapeutic Class: Antiemetic

Pharmacologic Class: Anticholinergic

Uses For Stemetic

Trimethobenzamide is used to treat nausea and vomiting .

This medicine is available only with your doctor's prescription .

Before Using Stemetic

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

No information is available on the relationship of age to the effects of intramuscular trimethobenzamide in the pediatric population. However, because of this medication's toxicity, use in children is contraindicated. Intramuscular trimethobenzamide should never be used in children .

Geriatric

No information is available on whether the risk of trimethobenzamide-induced adverse effects is increased in the elderly. However, because of this medication's toxicity, it should be used with caution, after less toxic alternatives have been considered and/or found ineffective. Recommended doses should not be exceeded, and the patient should be carefully monitored during therapy .

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Metoclopramide Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Dehydration or Electrolyte imbalance (high or low levels of minerals in the blood) or High fever or Intestinal infection, severe—May cause side effects to become worse . Proper Use of trimethobenzamide

This section provides information on the proper use of a number of products that contain trimethobenzamide. It may not be specific to Stemetic. Please read with care.

Trimethobenzamide is only used to relieve or prevent nausea and vomiting. A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into one of your muscles .

Your doctor may only give you a few doses of this medicine until your condition improves, and then may switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor .

Precautions While Using Stemetic

Trimethobenzamide will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicines for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicines; prescription pain medicines or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these medicines while you are using trimethobenzamide .

This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert .

Stemetic Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare Body spasm, with head and heels bent backward and body bowed forward convulsions (seizures) depression shakiness or tremors skin rash sore throat or fever unusual tiredness vomiting (severe or continuing) yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Drowsiness Less common Blurred vision diarrhea dizziness headache muscle cramps

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Stemetic side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Stemetic resources Stemetic Side Effects (in more detail)Stemetic Use in Pregnancy & BreastfeedingDrug ImagesStemetic Drug InteractionsStemetic Support Group3 Reviews for Stemetic - Add your own review/rating Compare Stemetic with other medications Nausea/Vomiting

Abbott Laboratories
Address Abbott Laboratories, 1 Abbott Park Road Abbott Park, IL 60064-3500Contact DetailsPhone: (847) 937-6100

Procyclidine Hydrochloride

Class: Anticholinergic AgentsVA Class: AU350CAS Number: 1508-76-5

Zelapar (Cephalon Limited)
1. Name Of The Medicinal Product

Zelapar 1.25 mg Oral Lyophilisate.

2. Qualitative And Quantitative Composition

Each Zelapar Oral Lyophilisate contains 1.25 mg of selegiline hydrochloride, equivalent to 1.05 mg selegiline free base.

Each tablet contains 1.25mg of aspartame (source of Phenylalanine)

For a full list of excipients, see section 6.1.

3. Pharmaceutical Form

Oral lyophilisate.

A pale yellow round tablet with the letter A on one side.

4. Clinical Particulars 4.1 Therapeutic Indications

Adjunctive therapy in combination with levodopa (with a peripheral decarboxylase inhibitor) in the treatment of Parkinson's disease. Zelapar in combination with maximal levodopa therapy is indicated particularly in patients who experience fluctuations in their condition such as 'end-dose' type fluctuations, 'on-off' symptoms or other dyskinesias.

Zelapar may be used alone in early Parkinson's disease for symptomatic relief and/or to delay the need for levodopa.

4.2 Posology And Method Of Administration

Posology

When prescribed as monotherapy for the first time in the early stage of Parkinson's disease or as an adjuvant to levodopa, the dose of Zelapar is one 1.25 mg unit.

When Zelapar adjunctive therapy is prescribed a reduction (10 to 30%) in the dose of levodopa is usually required. Reduction of the levodopa dose should be gradual in steps of 10% every 3 to 4 days.

No dosage adjustment is required for patients with renal or hepatic impairment.

Method of administration

The unit should be placed on the tongue in the morning, at least five minutes before breakfast and allowed to dissolve.

The unit will dissolve rapidly (in less than 10 seconds) in the mouth. The patient should not eat, drink, rinse or wash-out out their mouth for five minutes after taking their medicine to enable selegiline to be absorbed pre-gastrically.

Do not push the Zelapar tablet through the foil blister. Peel back the foil and carefully remove the unit.

Unused tablets must be disposed of after three months of a sachet opening.

4.3 Contraindications

Hypersentitivity to the active substance or to any of the excipients.

Patients receiving treatment with serotonin-agonists (e.g. sumatriptan, naratriptan, zolmitriptan and rizatriptan).

Patients with phenylketonuria due to the content of aspartame, a source of phenylalanine.

Concomitant use with pethidine and other opioids.

Patients with other extrapyramidal disorders not related to dopamine deficiency.

Patients with active duodenal or gastric ulcer.

Patients who are being treated with antidepressant drugs, including MAO inhibitors and selective serotonin reuptake inhibitors (e.g citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline and venlafaxine. See section 4.5 interactions).

Concomitant use with other drugs which are also monoamine oxidase inhibitors, e.g. linezolid.

Combination with levodopa is contra-indicated in severe cardiovascular disease, arterial hypertension, hyperthyroidism, phaeochromocytoma, narrow-angle glaucoma, prostatic adenoma with appearance of residual urine, tachycardia, arrhythmias, severe angina pectoris, psychoses, advanced dementia and thyrotoxicosis.

4.4 Special Warnings And Precautions For Use

One unit of Zelapar contains 1.25 mg selegiline. It is recommended that patients be warned that the correct dose of Zelapar is one oral lyophilisate.

Special care should be taken when administering selegiline to patients who have labile hypertension, cardiac arrhythmias, severe angina pectoris, psychosis or a history of peptic ulceration.

Although serious hepatic toxicity has not been observed, caution is recommended in patients with a history of hepatic dysfunction. Transient or continuing abnormalities with a tendency for elevated plasma concentrations of liver enzymes have been described during long-term therapy with conventional tablets of selegiline.

The selectivity for MAO

Concomitant treatment with medicines which inhibit MAO

Since selegiline potentiates the effects of levodopa, the adverse effects of levodopa may be increased. When selegiline is added to the maximum tolerated dose of levodopa, involuntary movements and agitation may occur. Levodopa should be reduced by about 10 to 30% when selegiline is added to the treatment (see section 4.2 Posology and Method of Administration). When an optimum dose of levodopa is reached, adverse effects from the combination are less than those observed with levodopa on its own.

Although conventional tablets of selegiline, at doses of 5 to 10 mg/day, have been in widespread use for many years, the full spectrum of possible responses to Zelapar may not have been observed to date. Therefore patients should be observed closely for atypical responses.

Mouth ulcers may occur during treatment with Zelapar 1.25 mg oral lyophilisate.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Selegiline should not be administered with any type of antidepressant.

When selegiline is used at its recommended dose, it selectively inhibits MAO-B. The combined use of the SSRI, fluoxetine and Zelapar, should only be used under clinical supervision. Use of Zelapar beyond the recommended dose could lead to non-selectivity and serious adverse effects.

Serious reactions with signs and symptoms that may include diaphoresis, flushing, ataxia, tremor, hyperthermia, hyper/hypotension, seizures, palpitation, dizziness and mental changes that include agitation, confusion and hallucinations progressing to delirium and coma have been reported in some patients receiving a combination of selegiline and fluoxetine. Similar experience has been reported in patients receiving selegiline and two other serotonin reuptake inhibitors, sertraline and paroxetine. There is a potential risk of interaction with fluvoxamine and venlafaxine.

Death has been reported to occur following the initiation of therapy with non

At least 14 days should lapse between the discontinuation of selegiline and initiation of treatment with any drug known to interact with selegiline.

A time interval of 24 hours is recommended between the discontinuation of selegiline and initiation of serotonin agonists.

Patients being treated with selegiline currently or within the past 2 weeks should receive dopamine only after careful risk-benefit assessment, as this combination enhances the risk of hypertensive reactions.

Selegiline should not be given in conjunction with non

Severe CNS toxicity has been reported in patients with the combination of tricyclic antidepressants and selegiline. In one patient receiving amitriptyline and selegiline this included hyperpyrexia and death, and another patient receiving protriptyline and selegiline experienced tremor, agitation, and restlessness followed by unresponsiveness and death two weeks after selegiline was added.

Other adverse reactions occasionally reported in patients receiving a combination of selegiline with various tricyclic antidepressants include hyper/hypotension, dizziness, diaphoresis, tremor, seizures and changes in behavioural and mental status.

Concomitant use of sympathomimetics, nasal decongestants, hypertensive agents, anti-hypertensives, psychostimulants, central suppressant drugs (sedatives, hypnotics) and alcohol should be avoided.

The combination of selegiline and oral contraceptives or drugs for hormone replacement therapy, should be avoided, as this combination may multiply the bioavailability of selegiline.

Foodstuffs containing tyramine have not been found to cause hypertensive reactions during therapy with conventional selegiline tablets at dosages recommended for the treatment of Parkinson's disease. As the selectivity of action of Zelapar for MAO

Concomitant administration of amantadine and anticholinergic drugs can lead to an increased occurrence of side-effects.

In view of the high degree of binding to plasma proteins by selegiline particular attention must be given to patients who are being treated with medicines with a narrow therapeutic margin such as digitalis and/or anticoagulants.

Four patients receiving altretamine and a monamine oxidase inhibitor experienced symptomatic hypotension after four to seven days of concomitant therapy.

Interactions between non-selective MAO

4.6 Pregnancy And Lactation

Selegiline is indicated for the treatment of Parkinson's disease which, in most cases, is a disease occurring after childbearing age. As no work has been done to assess the effects of selegiline on pregnancy and lactation, it should not be used in such cases.

Selegiline should not be used by mothers when breastfeeding as information is lacking concerning whether selegiline passes into breast milk.

4.7 Effects On Ability To Drive And Use Machines

Zelapar has major influence on the ability to drive and use machines, therefore patients should avoid these activities.

4.8 Undesirable Effects

The following undesirable effects have been reported with Zelapar during clinical trials and/or post-marketing use. They are listed below as MedDRA preferred term by system organ class and frequency. Frequencies are defined as: undesirable effects very common (>1/10), common (

System Organ Class

Frequency

Undesirable effects

Psychiatric disorders

common

Confusion, depression, hallucinations, insomnia,

 

uncommon

abnormal dreams, agitation, anxiety, psychoses

Nervous system disorders

common

Dizziness, dyskinesia (including akinesia, bradykinesia), headache, impaired balance, tremor,

Ear and labyrinth disorders

common

vertigo

Cardiac disorders

uncommon

angina pectoris

Vascular disorders

common

Hypertension, hypotension

Respiratory, thoracic and mediastinal disorders

common

nasal congestion, sore throat

uncommon

dyspnoea

 

Gastrointestinal disorders

very common

stomatitis

 

common

constipation, diarrhoea, dry mouth, mouth ulceration, nausea

Skin and subcutaneous tissue disorders

common

sweating increased

Musculoskeletal and connective tissue disorders

common

arthralgia, back pain, muscle cramps

General disorders and administration site conditions

common

fatigue

uncommon

chest pain, irritability

 

Injury, poisoning and procedural complications

common

fall

The following undesirable effects have been reported with selegiline, with an uncommon frequency (

System Organ Class

Undesirable effects

Infections and infestations

pharyngitis

Blood and lymphatic system disorders

Leucocytopenia, thrombocytopenia

Metabolism and nutrition disorders

loss of appetite

Eye disorders

blurred vision

Cardiac disorders

Arrhythmias, palpitations

Vascular disorders

orthostatic hypotension

Skin and subcutaneous tissue disorders

hair loss, skin eruptions

Musculoskeletal and connective tissue disorders

myopathy

Renal and urinary disorders

micturition disorders

General disorders and administration site conditions

ankle oedema

Investigations

transient transaminase increase (ALAT), transient increase in liver enzyme values

In the first 5 years of marketing experience with Zelapar,the following adverse reactions were reported: nausea, confusional state, dizziness, hallucinations and vertigo.

As selegiline potentiates the effect of levodopa, the side-effects of levodopa may be emphasised unless the dosage of levodopa is reduced. The most common undesirable effect reported for conventional tablets is dyskinesia (4% of patients). Once the optimum levodopa dose level has been established, the side-effects produced by the combination will usually be less than those caused by the levodopa therapy on its own.

4.9 Overdose

Zelapar is rapidly metabolised and the metabolites rapidly excreted. In cases of suspected overdosage the patient should be kept under observation for 24 to 48 hours.

No specific information is available about clinically significant overdoses with Zelapar. However, experience gained in use of conventional tablets of selegiline reveals that some individuals exposed to doses of 60 mg/day suffered severe hypotension and psychomotor agitation.

Since the selective inhibition of MAO

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Pharmacotherapeutic group: Monoamine oxidase B inhibitors, ATC Code: N04B D01

Zelapar selectively inhibits MAO?

The magnitude of increase in the urinary excretion of ???

Combined with levodopa therapy selegiline reduces, in particular, fluctuation in the condition of patients who suffer from parkinsonism, e.g. on-off symptoms or end

In a clinical trial where patients were switched from 10 mg conventional selegiline tablets to 1.25 mg Zelapar oral lyophilisate, control of motor symptoms was maintained.

Zelapar may be useful in those patients with Parkinson's disease who experience difficulties in swallowing.

5.2 Pharmacokinetic Properties

Zelapar dissolves completely within 10 seconds of placing on the tongue and, in contrast to conventional tablets, selegiline is absorbed primarily pregastrically.

The plasma concentrations of selegiline following single doses of Zelapar 1.25 mg are of the same order as those obtained with conventional 10 mg tablets of selegiline, but are much less variable. The range of AUCs for plasma selegiline is 0.22 to 2.82 ng.h/ml for Zelapar 1.25 mg and 0.05 to 23.64 ng.h/ml for conventional 10 mg tablets. The Cmax ranges are 0.32 to 4.58 ng/ml and 0.07 to 16.0 ng/ml respectively.

After Zelapar 1.25 mg, plasma concentrations of selegiline metabolites, Ndesmethylselegiline, llamphetamine, were reduced by between 88% and 92% in comparison with the concentrations reached after conventional selegiline tablets 10 mg.

Ninety-four per cent of plasma selegiline is reversibly bound to plasma protein. Selegiline is mainly eliminated by metabolism. It is excreted mainly in the urine as metabolites (mainly l

5.3 Preclinical Safety Data

Selegiline has not been sufficiently tested for reproductive toxicity. Studies with selegiline revealed no evidence of mutagenic or carcinogenic effects. The only safety concerns for human use derived from animal studies were effects associated with an exaggerated pharmacological action.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Gelatin

Mannitol

Glycine

Aspartame

Citric Acid anhydrous

Grapefruit flavour

Yellow Colouring (yellow iron oxide [E172], hypromellose [E464]).

6.2 Incompatibilities

Not applicable.

6.3 Shelf Life

Sealed sachets - 3 years.

Opened sachets - 3 months.

6.4 Special Precautions For Storage

Do not store above 25°C.

6.5 Nature And Contents Of Container

PVC/PE/PVdC blister packs sealed with aluminium foil enclosed in a paper/PE/aluminium foil/PE sachet. Each pack contains 10, 30, 60 or 100 oral lyophilisates. Not all pack sizes may be marketed.

6.6 Special Precautions For Disposal And Other Handling

No special requirements.

7. Marketing Authorisation Holder

Cephalon UK Limited

1 Albany Place

Hyde Way

Welwyn Garden City

Hertfordshire

AL7 3BT

United Kingdom

8. Marketing Authorisation Number(S)

PL 16260/0031

9. Date Of First Authorisation/Renewal Of The Authorisation

04 June 2010

10. Date Of Revision Of The Text

20 June 2010

NexMed, Inc
Address NexMed, Inc, 89 Twin Rivers Drive East Windsor, NJ 08520 Contact DetailsPhone: (609) 371-8123

Lopinavir/Ritonavir Capsules
Generic Name: Lopinavir/Ritonavir (loe-PIN-a-vir/rit-OH-na-vir)Brand Name: Kaletra Lopinavir/Ritonavir Capsules is used for:

Managing HIV infection in combination with other medicines. Lopinavir/Ritonavir Capsules is not a cure for HIV infection or AIDS.

Lopinavir/Ritonavir Capsules is an HIV protease inhibitor. It works by blocking a chemical that HIV needs to multiply, which reduces the amount of HIV in the blood.

Do NOT use Lopinavir/Ritonavir Capsules if: you are allergic to any ingredient in Lopinavir/Ritonavir Capsules you are taking alfuzosin, astemizole, atorvastatin, cisapride, dihydrolam, an ergot derivative (eg, ergotamine), ergonovine, flecainide, fluticasone, lovastatin, methylergonovine, midazolam, pimozide, propafenone, rifampin, simvastatin, St. John's wort (Hypericum perforatum), terfenadine, tipranavir, triazolam, or voriconazole

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lopinavir/Ritonavir Capsules:

Some medical conditions may interact with Lopinavir/Ritonavir Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have AIDS, pancreatitis (swelling or tenderness of the abdomen), diabetes or high blood sugar (hyperglycemia), high cholesterol or triglyceride levels, or hemophilia or other bleeding disorders

Some MEDICINES MAY INTERACT with Lopinavir/Ritonavir Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

Many prescription and nonprescription medicines (eg, used for infections, inflammation, aches and pains, high blood pressure, high cholesterol, seizures), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) may interact with Lopinavir/Ritonavir Capsules, increasing the risk of their side effects Voriconazole because its effectiveness may be decreased by Lopinavir/Ritonavir Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lopinavir/Ritonavir Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lopinavir/Ritonavir Capsules:

Use Lopinavir/Ritonavir Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Lopinavir/Ritonavir Capsules by mouth with food. Continue to take Lopinavir/Ritonavir Capsules even if you feel well. Do not miss any doses. Lopinavir/Ritonavir Capsules must be taken with other HIV medicines to be effective. If you are also taking didanosine, take Lopinavir/Ritonavir Capsules 1 hour before or 2 hours after taking didanosine. Lopinavir/Ritonavir Capsules works best when there is a constant level of Lopinavir/Ritonavir Capsules in your body. It is important not to miss doses of Lopinavir/Ritonavir Capsules. If you miss a dose of Lopinavir/Ritonavir Capsules, take it as soon as you remember. If it is within 2 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lopinavir/Ritonavir Capsules.

Important safety information: Lopinavir/Ritonavir Capsules may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Lopinavir/Ritonavir Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Before you begin taking any new medicine, either prescription or nonprescription, check with your doctor or pharmacist. Talk with your doctor about which medicines should not be taken with Lopinavir/Ritonavir Capsules. Lopinavir/Ritonavir Capsules may increase the cholesterol and triglyceride levels in your blood. Cholesterol and triglyceride testing should be done before and during treatment with Lopinavir/Ritonavir Capsules. Patients with hepatitis B or hepatitis C who take Lopinavir/Ritonavir Capsules may have worsening liver disease. Tell your doctor before taking Lopinavir/Ritonavir Capsules if you have liver problems. Changes in body fat (eg, an increased amount of fat in the upper back, neck, breast, and trunk, and loss of fat from the legs, arms, and face) may occur in some patients taking Lopinavir/Ritonavir Capsules. The cause and long-term effects of these changes are unknown. Discuss any concerns with your doctor. When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Lopinavir/Ritonavir Capsules, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat. Lopinavir/Ritonavir Capsules is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor. Lopinavir/Ritonavir Capsules does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors. Hormonal birth control (eg, birth control pills) may not work as well while you are using Lopinavir/Ritonavir Capsules. To prevent pregnancy, use an extra form of birth control (eg, condoms). Hemophilia patients - Report all bleeding episodes to your doctor. Diabetes patients - Lopinavir/Ritonavir Capsules may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Lopinavir/Ritonavir Capsules may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Lopinavir/Ritonavir Capsules. Lopinavir/Ritonavir Capsules should not be used in CHILDREN younger than 14 days old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lopinavir/Ritonavir Capsules while you are pregnant. It is not known if Lopinavir/Ritonavir Capsules is found in breast milk. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Lopinavir/Ritonavir Capsules to the baby. Possible side effects of Lopinavir/Ritonavir Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal stools; chills; depression; diarrhea; fever; gas; headache; indigestion; loss of appetite; muscle pain; nausea; pain; prickling or tingling sensation on the skin; shift in body fat to stomach and upper body; sleeplessness; stomach pain; tiredness; vomiting; weakness; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in stool; dark urine; drowsiness; fatigue; flushed face; increased blood sugar; increased thirst or urination; persistent fever; severe stomach pain with nausea and vomiting; unusual bleeding or bruising; unusual hunger; vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Lopinavir/Ritonavir side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include change in the amount of urine; loss of consciousness; numbness or tingling in the arms, legs, hands, or feet; shallow breathing.

Proper storage of Lopinavir/Ritonavir Capsules:

Store in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Avoid exposure to excessive heat. Store away from heat, moisture, and light. Do not store in the bathroom. Throw away any unused medicine after the expiration date printed on label. Use within 2 months if stored at room temperature up to 77 degrees F (25 degrees C). Keep Lopinavir/Ritonavir Capsules out of the reach of children and away from pets.

General information: If you have any questions about Lopinavir/Ritonavir Capsules, please talk with your doctor, pharmacist, or other health care provider. Lopinavir/Ritonavir Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Lopinavir/Ritonavir Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Lopinavir/Ritonavir resources Lopinavir/Ritonavir Side Effects (in more detail)Lopinavir/Ritonavir Use in Pregnancy & BreastfeedingLopinavir/Ritonavir Drug InteractionsLopinavir/Ritonavir Support Group3 Reviews for Lopinavir/Ritonavir - Add your own review/rating Compare Lopinavir/Ritonavir with other medications HIV InfectionNonoccupational Exposure

Methadone Dispersible Tablets
Pronunciation: METH-uh-dohnGeneric Name: MethadoneBrand Name: Methadose

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