interferon alfacon-1 Subcutaneous


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interferon alfacon-1 Subcutaneous


in-ter-FEER-on AL-fa-kon-1

Subcutaneous route(Solution)

May cause or aggravate fatal or life-threatening neuropsychiatric, autoimmune, ischemic, and infectious disorders. Monitor closely and withdraw therapy with persistently severe or worsening signs or symptoms of the above disorders. Ribavirin may cause birth defects and fetal death; avoid pregnancy in female patients and in female partners of male patients. Ribavirin causes hemolytic anemia which may exacerbate cardiac disease. Ribavirin is a potential carcinogen .

Commonly used brand name(s)

In the U.S.


Available Dosage Forms:


Therapeutic Class: Immunological Agent

Pharmacologic Class: Interferon, Alfa (class)

Uses For interferon alfacon-1

Interferon alfacon-1 is used to treat chronic hepatitis C in adults. Hepatitis C is a liver infection. Interferons are natural substances that are produced in the body to help fight infections. Interferon alfacon-1 is a synthetic (man-made) version of these substances. interferon alfacon-1 will not keep you from giving hepatitis C to other people.

interferon alfacon-1 is available only with your doctor's prescription.

Before Using interferon alfacon-1

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For interferon alfacon-1, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to interferon alfacon-1 or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of interferon alfacon-1 in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of interferon alfacon-1 in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving interferon alfacon-1.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking interferon alfacon-1, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using interferon alfacon-1 with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Rotavirus Vaccine, Live Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of interferon alfacon-1. Make sure you tell your doctor if you have any other medical problems, especially:

Angina (severe chest pain) or Bleeding problems or Bone marrow problems (e.g., aplastic anemia, neutropenia, thrombocytopenia) or Depression or mental problems, history of or Diabetes or Diabetic retinopathy (eye problem caused by diabetes), history of or Eye or vision problems (e.g., bleeding, retinopathy), history of or Heart attack, history of or Heart or blood vessel disease, history of or Heart rhythm problems (e.g., arrhythmia) or Hyperglycemia (high blood sugar) or Hypertension (high blood pressure) or Hypertensive retinopathy (eye problem caused by increased blood pressure) or Hypertriglyceridemia (high fats or triglycerides in the blood) or Hypotension (low blood pressure) or Idiopathic thrombocytopenic purpura (autoimmune disorder) or Intestinal problems (e.g., colitis) or Kidney disease or Liver disease (e.g., cirrhosis) or Lung disease or other breathing problems (e.g., COPD, interstitial pneumonitis, pneumonia, sarcoidosis), or history of or Organ transplant, history of or Psoriasis (skin disease) or Rheumatoid arthritis or Stroke, history of or Systemic lupus erythematosus (SLE) (immune system disorder) or Thyroid disease, history of or Weak immune system (e.g., cancer, HIV infection)—Use with caution. May make these conditions worse. Autoimmune hepatitis (liver inflammation) or Decompensated liver disease or Kidney disease, severe or Sickle cell anemia (red blood cell disorder) or Thalassemia major (genetic blood disorder)—Should not be used in patients with these conditions. Infection—May decrease your body's ability to fight infection. Proper Use of interferon alfacon-1

A nurse or other trained health professional will give you interferon alfacon-1. interferon alfacon-1 is given as a shot under your skin.

You may also be taught how to give interferon alfacon-1 at home. Make sure you understand all of the instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

Each package of interferon alfacon-1 contains a medication guide. Carefully read the guide and make sure you understand:

How to prepare the injection. How to properly use a disposable syringe. How to give yourself the injection. How to store the vial of medicine. How long the vial can be stored and used.

You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.

Use a new needle and syringe each time you inject your medicine.

To help clear up your infection completely, interferon alfacon-1 must be used for the full time of treatment, even if you begin to feel better after a few days or weeks. It is also very important that you receive your injection at the same time of day for each dose.

Use each vial (glass container) only one time. If the vial contains extra medicine, throw it away.

If you have any questions about any of this, check with your doctor.

Do not change to another brand of interferon without checking with your doctor first. Different types of interferon require different doses. If you refill your medicine and it looks different, check with your pharmacist.

If you have any questions about this information, check with your doctor.


The dose of interferon alfacon-1 will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of interferon alfacon-1. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For injection dosage form: For hepatitis C: For patients receiving interferon alfacon-1 only: Adults—9 micrograms (mcg) injected under the skin three times per week. The injections should be spaced at least 48 hours apart. Children—Use is not recommended. For patients receiving interferon alfacon-1 together with ribavirin: Adults—15 micrograms (mcg) injected under the skin once a day. It is taken together with 1000 to 1200 milligrams (mg) of ribavirin divided in two small doses per day. Children—Use is not recommended. Missed Dose

If you miss a dose of interferon alfacon-1, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

After you take the missed dose, call your doctor for instructions.


Store in the refrigerator. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Allow interferon alfacon-1 to reach room temperature before using it. Do not shake the vial or expose it to direct sunlight.

Throw the used needles away in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Precautions While Using interferon alfacon-1

It is very important that your doctor check your progress at regular visits to make sure that interferon alfacon-1 is working properly. Blood tests may be needed to check for unwanted effects.

Using interferon alfacon-1 together with ribavirin while you are pregnant can harm your unborn baby. The medicine may also cause birth defects if the father is using it when his sexual partner becomes pregnant. If a pregnancy occurs while you are using interferon alfacon-1, tell your doctor right away.

A negative pregnancy test is needed in women who are of childbearing age before starting combination treatment with interferon alfacon-1 and ribavirin. Two forms of birth control must be used during treatment and for six months after treatment ends. You will need to have pregnancy tests done regularly to make sure you are not pregnant while being treated with these medicines and after your treatment ends.

interferon alfacon-1 commonly causes a flu-like reaction, with aching muscles, fever, chills, and headache. Using your shot at bedtime may allow you to sleep through the symptoms. Your doctor may want you to take a medicine for pain and fever (such as acetaminophen or ibuprofen) before or after each dose of interferon alfacon-1. Carefully follow your doctor's instructions about how to prevent or treat these symptoms.

interferon alfacon-1 may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away.

interferon alfacon-1 may lower the number of white blood cells in the blood. This will increase your chance of getting an infection. It can also lower the number of platelets in the blood. Platelets are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Check with your doctor immediately if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin. Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Be careful not to cut yourself when you are using sharp objects, such as a safety razor or fingernail or toenail cutters. Avoid contact sports or other situations where bruising or injury could occur.

interferon alfacon-1 may cause serious allergic reactions including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using interferon alfacon-1.

Stop using interferon alfacon-1 and check with your doctor right away if you have fever, stomach cramps, tenderness, pain, or watery or bloody diarrhea. These may be symptoms of a serious stomach problem called colitis.

Pancreatitis may occur while you are using interferon alfacon-1. Tell your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness.

Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral neuropathy.

Check with your doctor right away if you are having trouble breathing or if you experience a respiratory infection (such as pneumonia). This could result in a serious respiratory condition.

interferon alfacon-1 may cause high blood sugar levels. If you are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

interferon alfacon-1 Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common Anxiety black, tarry stools blood in the urine or stools body aches or pain burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings chest pain confusion congestion cough or hoarseness crying delusions dementia depersonalization depression diarrhea difficult or labored breathing dryness or soreness of the throat dysphoria euphoria feeling unusually cold fever or chills general feeling of discomfort or illness headache increased sweating joint pain loss of appetite lower back or side pain mental depression muscle aches and pains nausea nervousness painful or difficult urination paranoia pinpoint red spots on the skin quick to react or overreact emotionally rapidly changing moods redness at the place of injection runny nose shivering shortness of breath sore throat sweating tender, swollen glands in the neck tightness in the chest trouble with sleeping trouble with swallowing trouble with thinking or concentrating unusual bleeding or bruising unusual tiredness or weakness voice changes wheezing Less common Irregular heartbeat Rare Blurred vision or loss of vision skin rash, hives, or itching Incidence not known Abdominal or stomach pain bleeding gums bloody or black, tarry stools change in walking and balance clay-colored stools clumsiness or unsteadiness confusion constipation coughing up blood dark-colored urine decreased urination difficulty with breathing or swallowing dizziness dry mouth fainting fast heartbeat full or bloated feeling increase in heart rate increased menstrual flow or vaginal bleeding lightheadedness loss of consciousness muscle cramps or spasms nosebleeds paralysis pressure in the stomach prolonged bleeding from cuts rapid, shallow breathing red or black, tarry stools red or dark brown urine seizures severe stomach pain shakiness and unsteady walk shakiness in the legs, arms, hands, or feet sunken eyes swelling of the abdominal or stomach area thirst trembling or shaking of the hands or feet unpleasant breath odor unsteadiness, trembling, or other problems with muscle control or coordination vomiting of blood or material that looks like coffee grounds wrinkled skin yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Acid or sour stomach aching muscles back pain belching decreased appetite difficulty with moving feeling of warmth general feeling of discomfort or illness hair loss heartburn or indigestion lack or loss of strength loss of memory muscle pain or stiffness pain in the back or joints pain in the limbs, muscles, or neck pain or tenderness around the eyes and cheekbones problems with memory redness of the face, neck, arms, and occasionally, upper chest sleeplessness stomach discomfort, upset, or pain stuffy nose sudden sweating swollen joints thinning of the hair unable to sleep weight loss Incidence not known Being forgetful bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site blistering, peeling, or loosening of the skin bone pain burning feeling in the chest or stomach change in vision difficulty with moving difficulty with speaking false beliefs that cannot be changed by facts hearing loss pain, swelling, or redness in the joints red, irritated eyes red skin lesions, often with a purple center seeing, hearing, or feeling things that are not there sores, ulcers, or white spots in the mouth or on the lips

Interferon alfacon-1 may cause a temporary loss of some hair. After treatment has ended, normal hair growth should return.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: interferon alfacon-1 Subcutaneous side effects (in more detail)

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