incobotulinumtoxina Intramuscular


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incobotulinumtoxina Intramuscular



Intramuscular route(Powder for Solution)

The effects of incobotulinumtoxinA and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity, but symptoms can also occur in adults, particularly in those patients who have underlying conditions that would predispose them to these symptoms. Cases of spread of effect have occurred at doses comparable to those used to treat cervical dystonia and at lower doses .

Commonly used brand name(s)

In the U.S.


Available Dosage Forms:

Powder for Solution

Pharmacologic Class: Botulinum Toxin Type A

Uses For incobotulinumtoxina

IncobotulinumtoxinA is used to treat the abnormal head position and neck pain that result from cervical dystonia (severe muscle spasms of the neck). incobotulinumtoxina is also used to treat certain eye condition called blepharospasm (a condition where the eyelid will not stay open because of a muscle spasm) in patients who have already been treated with onabotulinumtoxinA (Botox®). IncobotulinumtoxinA is also used cosmetically to improve the appearance of deep facial lines or wrinkles between the eyebrows (glabellar lines).

IncobotulinumtoxinA is a botulinum toxin A product. It works on the nervous system to relax the muscles.

incobotulinumtoxina is available only with your doctor's prescription and will be administered by your doctor.

Before Using incobotulinumtoxina

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For incobotulinumtoxina, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to incobotulinumtoxina or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of incobotulinumtoxinA in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of incobotulinumtoxinA in the elderly. However, elderly patients are more likely to have side effects such as difficulty with swallowing, lack or loss of strength, or dizziness, which may require caution in patients receiving incobotulinumtoxinA.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of incobotulinumtoxina. Make sure you tell your doctor if you have any other medical problems, especially:

Amyotrophic lateral sclerosis (Lou Gehrig's disease) or Cornea or eye problems (e.g., ulcers) or Lambert-Eaton syndrome (nerve-muscle disorder) or Motor neuropathy (muscle and nerve problem) or Myasthenia gravis (severe muscle weakness)—May increase risk for more serious side effects. Breathing problems (e.g., asthma, emphysema) or Dysarthria (trouble with speaking) or Dysphagia (trouble with swallowing) or Dysphonia (voice problem) or Glaucoma, narrow angle or Ptosis (droopy eyelid) or Urinary incontinence (problems passing urine)—Use with caution. May make these conditions worse. Infection at the injection site—Should not be used in patients with this condition. Proper Use of incobotulinumtoxina

Your doctor will give you incobotulinumtoxina in a hospital or clinic setting. incobotulinumtoxina is given as a shot into one of your muscles.

incobotulinumtoxina should come with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Your doctor will only use incobotulinumtoxinA (Xeomin®) to treat your condition. Other botulinum toxin products may not work the same way.

Precautions While Using incobotulinumtoxina

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

Serious muscle reactions have been reported within hours to weeks after receiving incobotulinumtoxina. If you start to have muscle weakness, loss of bladder control, or trouble with swallowing, talking, or breathing, call your doctor right away. In some situations, these problems could be life-threatening and may require treatment in a hospital or clinic.

incobotulinumtoxina may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using incobotulinumtoxina.

incobotulinumtoxina may make your muscles weak and cause vision problems. Avoid driving, using machines, or doing anything else that could be dangerous if you feel weak or are not able to see well.

incobotulinumtoxina may reduce blinking of the eye which can lead to an increased risk of eye problems (such as corneal exposure and ulcers). Tell your doctor right away if you have a reduced blinking of the eye.

After you have received incobotulinumtoxina and your vision or muscle spasms are better, you may find that you are a lot more active than you were before. You should slowly increase your activities to allow time for your body to get stronger. Also, before you start an exercise program, check with your doctor.

One part of incobotulinumtoxina is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made of human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during the manufacture of these medicines. Although the risk is low, talk with your doctor if you have concerns.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

incobotulinumtoxina Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common—for cervical dystonia Difficulty with swallowing muscle or bone pain muscle weakness pain in the neck More common—for blepharospasm Dry eyes Rare—for glabellar lines Itching, pain, redness, or swelling at the injection site pain in the face swelling of the eyelids Incidence not known Changes in patterns and rhythms of speech fast heartbeat fever hives hoarseness irritation itching joint pain, stiffness, or swelling muscle spasm pain at the injection site rash redness of the skin shortness of breath slurred speech swelling of the eyes or eyelids swelling of the face, lips, hands, or feet tightness in the chest trouble with speaking troubled breathing or swallowing wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common—for cervical dystonia Chills cough lower back or side pain painful or difficult urination More common—for blepharospasm Blurred vision diarrhea drooping upper eyelids dry mouth headache Less common—for blepharospasm Difficult or labored breathing muscle aches sneezing sore throat stuffy or runny nose unusual tiredness or weakness Rare—for glabellar lines Drooping of the eyelids increased blinking twitching of the eyelids Incidence not known Difficulty with moving joint pain muscle aching or cramping muscle pains or stiffness nausea painful blisters on the trunk of the body swollen joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: incobotulinumtoxina Intramuscular side effects (in more detail)

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