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Pronunciation: fos-IN-oh-pril/HYE-droe-KLOR-oh-THYE-a-zide
Generic Name: Fosinopril/Hydrochlorothiazide
Brand Name: Monopril HCT

Fosinopril/Hydrochlorothiazide can cause injury or death to the fetus if taken during pregnancy. If you think you may be pregnant, contact your doctor right away.

Fosinopril/Hydrochlorothiazide is used for:

Treating high blood pressure.

Fosinopril/Hydrochlorothiazide is an angiotensin-converting enzyme (ACE) inhibitor and thiazide diuretic combination. It works to lower your blood pressure by removing excess fluid from the body and causing blood vessels to relax or widen.

Do NOT use Fosinopril/Hydrochlorothiazide if: you are allergic to any ingredient in Fosinopril/Hydrochlorothiazide, other sulfonamide medicines (eg, sulfamethoxazole, glyburide, probenecid), or other ACE inhibitors (eg, lisinopril) you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or unusual hoarseness), including angioedema caused by treatment with an ACE inhibitor you are unable to urinate you are pregnant you are also taking dofetilide or ketanserin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Fosinopril/Hydrochlorothiazide:

Some medical conditions may interact with Fosinopril/Hydrochlorothiazide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are able to become pregnant if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of heart problems (eg, heart failure, aortic stenosis), blood vessel problems, blood flow problems, bone marrow problems, kidney or liver problems, high blood cholesterol or lipid levels, or gout if you have a history of a stroke, a recent heart attack, kidney transplant, allergies, or asthma if you have an autoimmune disease (eg, rheumatoid arthritis, lupus, scleroderma) if you are dehydrated, have low blood volume, severe diarrhea or vomiting, or low blood pressure if you have high blood potassium levels, low blood sodium levels, or are on a low-salt (sodium) diet if you have diabetes, especially if you are also taking aliskiren if you are receiving treatments to reduce sensitivity to bee or wasp stings if you are having dialysis or apheresis, or are scheduled to have major surgery if you have recently had a certain type of nerve surgery (sympathectomy) if you have never taken another medicine for high blood pressure

Some MEDICINES MAY INTERACT with Fosinopril/Hydrochlorothiazide. Tell your health care provider if you are taking any other medicines, especially any of the following:

Digoxin, dofetilide, or ketanserin because the risk of irregular heartbeat may be increased Adrenocorticotropic hormone (ACTH), corticosteroids (eg, prednisone), dextran sulfate, diazoxide, diuretics (eg, furosemide), or other medicines for high blood pressure because they may increase the risk of Fosinopril/Hydrochlorothiazide's side effects, including low blood pressure and blood potassium problems Angiotensin receptor blockers (ARBs) (eg, losartan) because the risk of serious kidney problems and high blood potassium levels may be increased Aldosterone blockers (eg, eplerenone), potassium-sparing diuretics (eg, spironolactone, triamterene), potassium supplements, salt substitutes containing potassium, or trimethoprim because the risk of high blood potassium levels may be increased Certain gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure may occur Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin) because the risk of serious damage to the kidneys (eg, decrease in amount of urine produced) may be increased or they may decrease Fosinopril/Hydrochlorothiazide's effectiveness Lithium, or thiopurines (eg, azathioprine) because the risk of their side effects may be increased by Fosinopril/Hydrochlorothiazide Insulin or other diabetes medicines (eg, glyburide), or methenamine because their effectiveness may be decreased by Fosinopril/Hydrochlorothiazide

This may not be a complete list of all interactions that may occur. Ask your health care provider if Fosinopril/Hydrochlorothiazide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Fosinopril/Hydrochlorothiazide:

Use Fosinopril/Hydrochlorothiazide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Fosinopril/Hydrochlorothiazide by mouth with or without food. Do not take an antacid that has aluminum, magnesium, or simethicone in it within 2 hours before or 2 hours after you take Fosinopril/Hydrochlorothiazide. If you take cholestyramine or colestipol, do not take it at the same time that you take Fosinopril/Hydrochlorothiazide. Talk with your doctor about how you should take cholestyramine or colestipol with Fosinopril/Hydrochlorothiazide. Take Fosinopril/Hydrochlorothiazide on a regular schedule to get the most benefit from it. Taking Fosinopril/Hydrochlorothiazide at the same time each day will help you remember to take it. Continue to use Fosinopril/Hydrochlorothiazide even if you feel well. Do not miss any doses. If you miss a dose of Fosinopril/Hydrochlorothiazide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Fosinopril/Hydrochlorothiazide.

Important safety information: Fosinopril/Hydrochlorothiazide may cause dizziness, light-headedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Fosinopril/Hydrochlorothiazide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Fosinopril/Hydrochlorothiazide may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Fosinopril/Hydrochlorothiazide may cause a serious side effect called angioedema. Black patients may be at greater risk of developing this side effect. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness. Fosinopril/Hydrochlorothiazide contains hydrochlorothiazide, a sulfonamide, which can cause certain eye problems (myopia, angle-closure glaucoma). Your risk may be increased if you are allergic to sulfonamide medicines (eg, sulfamethoxazole) or to penicillin antibiotics (eg, amoxicillin). Untreated angle-closure glaucoma can lead to permanent vision loss. If these eye problems occur, symptoms usually occur within hours to weeks of starting Fosinopril/Hydrochlorothiazide. Contact your doctor immediately if you experience symptoms such as vision changes (eg, decreased vision clearness) or eye pain. Check with your doctor before you use a salt substitute or a product that has potassium in it. Drink plenty of fluids while taking Fosinopril/Hydrochlorothiazide and avoid engaging in activities that cause excessive sweating. Dehydration, excessive sweating, vomiting, or diarrhea may lead to a fall in blood pressure. Contact your health care provider at once if any of these occur. A persistent, unproductive cough may occur. Tell your doctor if this occurs. If caused by Fosinopril/Hydrochlorothiazide, recovery is rapid when the medicine is stopped. Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms. Tell your doctor or dentist that you take Fosinopril/Hydrochlorothiazide before you receive any medical or dental care, emergency care, or surgery. Fosinopril/Hydrochlorothiazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Fosinopril/Hydrochlorothiazide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. Fosinopril/Hydrochlorothiazide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away. Diabetes patients - Fosinopril/Hydrochlorothiazide may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Fosinopril/Hydrochlorothiazide may interfere with certain lab tests, including parathyroid function and digoxin blood levels. Be sure your doctor and lab personnel know you are taking Fosinopril/Hydrochlorothiazide. Lab tests, including blood electrolytes, blood pressure, complete blood cell counts, kidney function, and liver function, may be performed while you use Fosinopril/Hydrochlorothiazide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Use Fosinopril/Hydrochlorothiazide with caution in the ELDERLY; they may be more sensitive to its effects. Fosinopril/Hydrochlorothiazide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. PREGNANCY and BREAST-FEEDING: Fosinopril/Hydrochlorothiazide may cause birth defects, or fetal or newborn death if you take it while you are pregnant. Do not become pregnant while you take Fosinopril/Hydrochlorothiazide. If you think you may be pregnant, contact your doctor right away. Fosinopril/Hydrochlorothiazide is found in breast milk. Do not breast-feed while taking Fosinopril/Hydrochlorothiazide. Possible side effects of Fosinopril/Hydrochlorothiazide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness or light-headedness when sitting up or standing; dry cough.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty swallowing or breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); blurred vision or other vision changes (eg, vision clearness); change in the amount of urine produced; chest pain; dark urine; difficult or painful urination; drowsiness; dry mouth; eye pain; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; joint pain or swelling; loss of appetite; mental or mood changes (eg, depression); muscle cramps, pain, or weakness; numbness or tingling; one-sided weakness; pale stools; red, swollen, blistered, or peeling skin; restlessness; severe or persistent cough; severe or persistent headache, dizziness, or light-headedness; severe or persistent nausea or vomiting; slurred speech; stomach pain (with or without nausea or vomiting); symptoms of high blood sugar (eg, fast breathing; flushing; fruit-like breath odor; increased thirst, hunger, or urination); symptoms of low blood sodium (eg, confusion, mental or mood changes, seizures, sluggishness); tremor; unusual bruising or bleeding; unusual thirst, tiredness, or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Fosinopril/Hydrochlorothiazide side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe or persistent dizziness or light-headedness; symptoms of blood electrolyte problems (eg, confusion; irregular heartbeat; mental or mood changes; muscle pain, weakness, or cramping; seizures; sluggishness); symptoms of dehydration (eg, drowsiness; dry eyes; fast heartbeat; nausea; restlessness; unusual thirst, tiredness, or weakness; vomiting).

Proper storage of Fosinopril/Hydrochlorothiazide:

Store Fosinopril/Hydrochlorothiazide between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Fosinopril/Hydrochlorothiazide out of the reach of children and away from pets.

General information: If you have any questions about Fosinopril/Hydrochlorothiazide, please talk with your doctor, pharmacist, or other health care provider. Fosinopril/Hydrochlorothiazide is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Fosinopril/Hydrochlorothiazide. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition Copyright © 2012 Wolters Kluwer Health, Inc. More Fosinopril/Hydrochlorothiazide resources Fosinopril/Hydrochlorothiazide Side Effects (in more detail) Fosinopril/Hydrochlorothiazide Use in Pregnancy & Breastfeeding Drug Images Fosinopril/Hydrochlorothiazide Drug Interactions Fosinopril/Hydrochlorothiazide Support Group 0 Reviews for Fosinopril/Hydrochlorothiazide - Add your own review/rating Compare Fosinopril/Hydrochlorothiazide with other medications High Blood Pressure

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