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Pronunciation: KOE-ni-VAP-tan
Generic Name: Conivaptan
Brand Name: Vaprisol
Conivaptan is used for:

Treating low blood sodium levels in certain patients.

Conivaptan is an arginine vasopressin receptor antagonist. It works by increasing fluid removal from the body, which helps to normalize blood sodium levels.

Do NOT use Conivaptan if: you are allergic to any ingredient in Conivaptan or to corn or corn products you have low blood sodium levels along with low blood or fluid volume you have severe kidney problems or you are not able to urinate you are taking certain azole antifungals (eg, ketoconazole, itraconazole), an HIV protease inhibitor (eg, indinavir, ritonavir), certain macrolide antibiotics (eg, clarithromycin), nefazodone, or telithromycin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Conivaptan:

Some medical conditions may interact with Conivaptan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have congestive heart failure, liver problems, or kidney problems if you have poor nutrition or you have an alcohol addiction

Some MEDICINES MAY INTERACT with Conivaptan. Tell your health care provider if you are taking any other medicines, especially any of the following:

Azole antifungals (eg, itraconazole, ketoconazole), HIV protease inhibitors (eg, indinavir, ritonavir), macrolides (eg, clarithromycin), nefazodone, or telithromycin because they may increase the risk of Conivaptan's side effects Amlodipine, benzodiazepines (eg, alprazolam, midazolam), or digoxin because the risk of their side effects may be increased by Conivaptan HMG-CoA reductase inhibitors (eg, atorvastatin) because the risk of serious muscle problems may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Conivaptan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Conivaptan:

Use Conivaptan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Conivaptan is given as an injection at your doctor's office, hospital, or clinic. Do not use Conivaptan if it contains particles, is cloudy or discolored, or if the container is cracked or damaged. If you miss a dose of Conivaptan, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Conivaptan.

Important safety information: Conivaptan may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Conivaptan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Conivaptan may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Severe side effects may occur if your blood sodium levels rise too quickly. Contact your doctor right away if you develop abnormal speech (eg, you are unable to speak), trouble swallowing, mental or mood changes, seizures, sluggishness, or weakness in the arms and legs. Diabetes patients - Conivaptan may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Lab tests, including blood sodium levels and neurologic tests, may be performed while you use Conivaptan. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Conivaptan should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. PREGNANCY and BREAST-FEEDING: Conivaptan may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Conivaptan while you are pregnant. It is not known if Conivaptan is found in breast milk. Do not breast-feed while taking Conivaptan. Possible side effects of Conivaptan:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dry mouth; headache; increased thirst; nausea; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; confusion; drowsiness; fast or irregular heartbeat; fever; increased or painful urination; increased sweating; mental or mood changes; muscle pain, weakness, or cramping; pain, irritation, redness, or swelling at the injection site; rapid breathing; severe or persistent dizziness; severe or persistent increase in thirst; tremor; unusual tiredness or weakness; white patches in the mouth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Conivaptan side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( ), or emergency room immediately. Symptoms may include fainting; severe or persistent dizziness; severe or persistent increase in thirst.

Proper storage of Conivaptan:

Conivaptan is usually handled and stored by a health care provider. If you are using Conivaptan at home, store Conivaptan as directed by your pharmacist or health care provider. Keep Conivaptan out of the reach of children and away from pets.

General information: If you have any questions about Conivaptan, please talk with your doctor, pharmacist, or other health care provider. Conivaptan is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Conivaptan. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition Copyright © 2012 Wolters Kluwer Health, Inc. More Conivaptan resources Conivaptan Side Effects (in more detail) Conivaptan Use in Pregnancy & Breastfeeding Conivaptan Drug Interactions Conivaptan Support Group 1 Review for Conivaptan - Add your own review/rating conivaptan Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information Conivaptan Hydrochloride Monograph (AHFS DI) Vaprisol Prescribing Information (FDA) Vaprisol Consumer Overview Compare Conivaptan with other medications Euvolemic Hyponatremia SIADH


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