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Generic Name: lubiprostone (Oral route)


Commonly used brand name(s)

In the U.S.


Available Dosage Forms:

Capsule, Liquid Filled Capsule

Therapeutic Class: Laxative

Uses For Amitiza

Lubiprostone is used to treat chronic constipation in adults. This medicine works by increasing intestinal fluid secretion, which helps ease the passage of stool and helps relieve the symptoms associated with constipation.

Lubiprostone is also used to treat irritable bowel syndrome (IBS) in women who have constipation as the main symptom.

This medicine is available only with your doctor's prescription.

Before Using Amitiza

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of lubiprostone in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of lubiprostone in the elderly.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Bowel blockage, or history of or Diarrhea, severe—Should not be used in patients with these conditions. Liver disease, moderate to severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of Amitiza

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Swallow the soft gelatin capsule whole. Do not crush, break, or chew it. It is best to take this medicine with food.

Drink at least 6 to 8 glasses (8 ounces each) of liquid each day. This will help make the stool softer.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (soft gelatin capsules): For chronic constipation: Adults—24 micrograms (mcg) two times a day (once in the morning and once in the evening) with food and water. Children—Use and dose must be determined by your doctor. For irritable bowel syndrome (IBS): Adults—8 micrograms (mcg) two times a day (once in the morning and once in the evening) with food and water. Children—Use and dose must be determined by your doctor. Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Amitiza

If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits for any problems or unwanted effects that may be caused by this medicine. This will also allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Lubiprostone may cause difficulty with breathing, nausea, or severe diarrhea. If your symptoms and condition do not improve within a few days, or if they become worse, check with your doctor.

If you are a woman who can get pregnant, your doctor may want you to have a negative pregnancy test before you will be allowed to take this medicine. Also, use an effective form of birth control to keep from getting pregnant. If you miss a period while you are using this medicine, tell your doctor right away.

Amitiza Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common Full or bloated feeling or pressure in the stomach stomach pain swelling of abdominal or stomach area Less common Bladder pain bloody or cloudy urine blurred vision chest discomfort chest pain chills cold flu-like symptoms cough that produces mucus diarrhea difficult, burning, or painful urination difficult or labored breathing difficulty having a bowel movement (stool) dizziness fast heartbeat fever frequent urge to urinate general feeling of discomfort or illness headache hoarseness joint pain loss of appetite lower back or side pain muscle aches and pains nausea nervousness pounding in the ears runny nose shivering shortness of breath sore throat sweating swelling of the hands, ankles, feet, or lower legs tightness in the chest trouble sleeping unusual tiredness or weakness vomiting wheezing Incidence not known Cough difficulty with swallowing fainting hives puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue skin rash

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose Burning, itching, redness, or stinging of the skin dry heaves feeling of warmth redness of the face, neck, arms and occasionally, upper chest increased sweating lack or loss of strength paleness of the skin severe, unusual tiredness or weakness slow heartbeat sudden sweating weight loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Excess air or gas in the stomach or intestines passing gas Less common Acid or sour stomach back pain belching body aches or pain burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings difficulty with moving discouragement dry mouth ear congestion fear feeling sad or empty heartburn increased weight indigestion irritability loss of interest or pleasure loss of voice muscle cramps muscle stiffness nasal congestion pain in the arms or legs pain or tenderness around the eyes and cheekbones sleeplessness sneezing stomach soreness, discomfort, or upset stuffy nose tiredness trouble concentrating unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Amitiza side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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More Amitiza resources Amitiza Side Effects (in more detail) Amitiza Use in Pregnancy & Breastfeeding Drug Images Amitiza Support Group 58 Reviews for Amitiza - Add your own review/rating Amitiza Prescribing Information (FDA) Amitiza Consumer Overview Amitiza Monograph (AHFS DI) Amitiza MedFacts Consumer Leaflet (Wolters Kluwer) Lubiprostone Professional Patient Advice (Wolters Kluwer) Compare Amitiza with other medications Constipation, Chronic Irritable Bowel Syndrome


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