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Pronunciation: a-seet-a-MIN-oh-fen/soo-do-e-FED-rin
Generic Name: Acetaminophen/Pseudoephedrine
Brand Name: Examples include Alka-Seltzer Plus Cold/Sinus and Ornex
Acetaminophen/Pseudoephedrine is used for:

Relieving symptoms such as pain and sinus congestion due to colds, upper respiratory infections, and allergies. It may also used for other conditions as determined by your doctor.

Acetaminophen/Pseudoephedrine is an analgesic and decongestant combination. The analgesic works in the brain to help decrease pain. The decongestant works by constricting blood vessels and reducing swelling in the nasal passages, which decreases stuffiness.

Do NOT use Acetaminophen/Pseudoephedrine if: you are allergic to any ingredient in Acetaminophen/Pseudoephedrine you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Acetaminophen/Pseudoephedrine:

Some medical conditions may interact with Acetaminophen/Pseudoephedrine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of adrenal gland problems (eg, adrenal gland tumor), heart problems, high blood pressure, diabetes, blood vessel problems, stroke, glaucoma, an enlarged prostate or other prostate problems, seizures, an overactive thyroid, severe kidney problems, or liver problems (eg, hepatitis), or if you consume more than 3 alcohol-containing drinks per day

Some MEDICINES MAY INTERACT with Acetaminophen/Pseudoephedrine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, isoniazid, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because side effects of Acetaminophen/Pseudoephedrine may be increased Anticoagulants (eg, warfarin), digoxin, or droxidopa because risk of bleeding, irregular heartbeat, or heart attack may be increased Bromocriptine or hydantoins (eg, phenytoin) because side effects may be increased by Acetaminophen/Pseudoephedrine Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because effectiveness may be decreased by Acetaminophen/Pseudoephedrine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Acetaminophen/Pseudoephedrine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Acetaminophen/Pseudoephedrine:

Use Acetaminophen/Pseudoephedrine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Acetaminophen/Pseudoephedrine may be taken with or without food. If you miss a dose of Acetaminophen/Pseudoephedrine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Acetaminophen/Pseudoephedrine.

Important safety information: Acetaminophen/Pseudoephedrine may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Acetaminophen/Pseudoephedrine. Using Acetaminophen/Pseudoephedrine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks. Do not take diet or appetite control medicines while you are taking Acetaminophen/Pseudoephedrine without checking with you doctor. Acetaminophen/Pseudoephedrine contains acetaminophen and pseudoephedrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains acetaminophen or pseudoephedrine. If it does or if you are uncertain, contact your doctor or pharmacist. Do NOT exceed the recommended dose or take Acetaminophen/Pseudoephedrine for longer than prescribed without checking with your doctor. If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor. Acetaminophen/Pseudoephedrine may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Acetaminophen/Pseudoephedrine. Use a sunscreen or protective clothing if you must be outside for a prolonged period. Acetaminophen/Pseudoephedrine may cause liver damage. If you consume 3 or more alcohol-containing drinks every day, ask your doctor if you should take Acetaminophen/Pseudoephedrine or other pain relievers/fever reducers. Alcohol use combined with Acetaminophen/Pseudoephedrine may increase your risk for liver damage. Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Acetaminophen/Pseudoephedrine. Use Acetaminophen/Pseudoephedrine with caution in the ELDERLY because they may be more sensitive to its effects. Caution is advised when using Acetaminophen/Pseudoephedrine in CHILDREN because they may be more sensitive to its effects. PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Acetaminophen/Pseudoephedrine, discuss with your doctor the benefits and risks of using Acetaminophen/Pseudoephedrine during pregnancy. Acetaminophen/Pseudoephedrine is excreted in breast milk. If you are or will be breast-feeding while you are using Acetaminophen/Pseudoephedrine, check with your doctor or pharmacist to discuss the risks to your baby. Possible side effects of Acetaminophen/Pseudoephedrine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; mood or mental changes; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; stomach pain; tremor; vision changes; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Acetaminophen/Pseudoephedrine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Acetaminophen/Pseudoephedrine:

Store Acetaminophen/Pseudoephedrine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Acetaminophen/Pseudoephedrine out of the reach of children and away from pets.

General information: If you have any questions about Acetaminophen/Pseudoephedrine, please talk with your doctor, pharmacist, or other health care provider. Acetaminophen/Pseudoephedrine is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Acetaminophen/Pseudoephedrine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition Copyright © 2012 Wolters Kluwer Health, Inc. More Acetaminophen/Pseudoephedrine resources Acetaminophen/Pseudoephedrine Side Effects (in more detail) Acetaminophen/Pseudoephedrine Dosage Acetaminophen/Pseudoephedrine Use in Pregnancy & Breastfeeding Acetaminophen/Pseudoephedrine Drug Interactions Acetaminophen/Pseudoephedrine Support Group 2 Reviews for Acetaminophen/Pseudoephedrine - Add your own review/rating Compare Acetaminophen/Pseudoephedrine with other medications Fever Sinus Symptoms

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