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Melanoma, Metastatic Medications


Drugs associated with Melanoma, Metastatic

The following drugs and medications are in some way related to, or used in the treatment of Melanoma, Metastatic. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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Micromedex Care Notes:

Melanoma
Drug List: Accutane Amnesteem Claravis Peg-Intron Sotret Sylatron Temodar Yervoy Zelboraf


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Zelboraf


Generic Name: vemurafenib (Oral route)

vem-ue-RAF-e-nib

Commonly used brand name(s)

In the U.S.

Zelboraf

Available Dosage Forms:

Tablet Uses For Zelboraf

Vemurafenib is used to treat melanoma (a type of skin cancer) that has spread or that cannot be removed by surgery. It is only used if the melanoma cells have the BRAF V600E mutation. Your doctor will use a special test to look for this mutation. Vemurafenib belongs to the group of medicines called antineoplastics (cancer medicines).

This medicine is available only with your doctor's prescription.

Before Using Zelboraf

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of vemurafenib in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of vemurafenib in the elderly. However, elderly patients are more likely to have unwanted effects (e.g., skin problems, decreased appetite, fast heartbeat, nausea, or swelling of the hands, feet, or legs) which may require caution in patients receiving vemurafenib.

Pregnancy Pregnancy Category Explanation All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Cisapride Dronedarone Levomethadyl Mesoridazine Posaconazole Saquinavir Sparfloxacin Thioridazine Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Alfentanil Alfuzosin Amiodarone Amitriptyline Amoxapine Apomorphine Arsenic Trioxide Asenapine Astemizole Atazanavir Azithromycin Carbamazepine Chloroquine Chlorpromazine Ciprofloxacin Citalopram Clarithromycin Clomipramine Clozapine Crizotinib Cyclosporine Dasatinib Desipramine Dihydroergotamine Disopyramide Dofetilide Dolasetron Droperidol Ergotamine Erythromycin Fentanyl Flecainide Fluconazole Gatifloxacin Gemifloxacin Granisetron Halofantrine Haloperidol Ibutilide Iloperidone Imipramine Indinavir Itraconazole Ketoconazole Lapatinib Levofloxacin Lumefantrine Mefloquine Methadone Moxifloxacin Nefazodone Nelfinavir Nilotinib Norfloxacin Nortriptyline Octreotide Ofloxacin Ondansetron Paliperidone Pazopanib Perflutren Lipid Microsphere Phenobarbital Phenytoin Pimozide Procainamide Prochlorperazine Promethazine Propafenone Protriptyline Quetiapine Quinidine Quinine Ranolazine Rifabutin Rifampin Rifapentine Ritonavir Salmeterol Sirolimus Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sorafenib Sotalol Sunitinib Tacrolimus Telavancin Telithromycin Terfenadine Tetrabenazine Theophylline Tizanidine Toremifene Trazodone Trifluoperazine Trimipramine Vandetanib Vardenafil Voriconazole

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Dextromethorphan Midazolam Warfarin Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Caffeine Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Congestive heart failure or Heart rhythm problems (e.g., QT prolongation, slow heartbeat) or Skin cancer, history of—May increase risk for more serious side effects. Heart rhythm problems (e.g., long QT syndrome) or Mineral imbalance (e.g., high or low potassium, calcium, magnesium), uncorrected—Use is not recommended in patients with these conditions. Kidney disease, severe or Liver disease, severe—Use with caution. This medicine has not been studied in patients with these conditions. Proper Use of Zelboraf

Medicines used to treat cancer are very strong and can have many side effects. Before using this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Take this medicine exactly as directed even if you feel well. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine comes with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Swallow the tablet whole with a glass of water. Do not crush, break, or chew it.

You may take this medicine with or without food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablet): For melanoma (skin cancer): Adults—960 milligrams (four 240 mg tablets) two times a day. The first dose should be taken in the morning, and the second dose in the evening. The two doses should be taken 12 hours apart. Children—Use and dose must be determined by your doctor. Missed Dose

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

If you miss a dose or forget to use this medicine, you may still take it up to 4 hours before your next regular dose time. If it is less than 4 hours until your next dose, skip the missed dose.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Zelboraf

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine may increase your risk of having cutaneous squamous cell carcinoma (cuSCC). This is more likely to occur if you are more than 65 years of age, have too much sun exposure, or a history of skin cancer. Your doctor may want your skin to be tested and checked for any new skin lesions before treatment and every 2 months while you are using this medicine.

This medicine may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Stop using this medicine and call your doctor right away if you have a rash; itching; hoarseness; lightheadedness or dizziness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

Serious skin reactions can occur with this medicine. Stop using this medicine and check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you are using this medicine.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine can cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or uneven heartbeats.

Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests (e.g., liver enzymes and bilirubin).

This medicine may make your skin more sensitive to sunlight. Avoid overexposing your skin to sunlight. Use sunscreen or sunblock lotions and lip balms with a sun protection factor (SPF) of at least 30 on a regular basis when you are outdoors. Wear protective clothing and hats and stay out of direct sunlight, especially between the hours of 10 a.m. and 3 p.m. Avoid sunlamps and tanning beds.

Check with your doctor right away if blurred vision, difficulty with reading, eye pain, or any other change in vision occurs while you are receiving this medicine. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Zelboraf Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common Blistering, peeling, or loosening of the skin bloating or swelling of the face, arms, hands, lower legs, or feet blurred vision or other change in vision chills cough diarrhea dizziness eye pain fainting fast or irregular heartbeat fever increased sensitivity of the skin to sunlight itching joint or muscle pain lump or growth on the skin pain in the ankles or knees painful, red lumps under the skin, mostly on the legs paralysis of the nerves rapid weight gain rash with flat lesions or small raised lesions on the skin red skin lesions, often with a purple center red, irritated eyes redness or other discoloration of the skin redness, soreness, swelling, or itching skin scaling of the skin on the hands and feet sensitivity of the eye to light severe sunburn skin rash sore throat sores, ulcers, or white spots in the mouth or on the lips sores, welting, or blisters tearing tingling of the hands and feet ulceration of the skin unusual tiredness or weakness unusual weight gain or loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Back or bone pain burning, itching, and pain in the hairy areas, or pus at the root of the hair change in taste cough decreased appetite decreased weight diarrhea difficulty having a bowel movement (stool) difficulty with moving dizziness dry skin hair loss or thinning of the hair headache lack or loss of strength loss of taste muscle stiffness nausea pain in the arms or legs rash sunburn vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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