Thioridazine Concentrate

Pronunciation: thye-oh-RID-a-zeen
Generic Name: Thioridazine
Brand Name: Generic only. No brands available.

Thioridazine Concentrate may increase your risk of severe irregular heartbeat or sudden death. Thioridazine Concentrate should only be used in patients who have not shown improvement with or are unable to take other medicines.

Thioridazine Concentrate is used for:

Treating schizophrenia in patients who have not shown improvement with or are unable to take other medicines. It may also be used for other conditions as determined by your doctor.

Thioridazine Concentrate is a phenothiazine. It is not known exactly how it works.

Do NOT use Thioridazine Concentrate if: you are allergic to any ingredient in Thioridazine Concentrate or similar medicines (eg, phenothiazines) you have a decreased level of consciousness, severe high or low blood pressure, low levels of potassium in the blood, abnormal heart function test (ECG), or a history of certain heart problems (eg, irregular heartbeat, congenital long QT syndrome) you have a genetic problem that leads to decreased levels of the P-450 2D6 isozyme in your body you are taking antiarrhythmics (eg, amiodarone, quinidine), cisapride, dofetilide, H1 antagonists (eg, astemizole, terfenadine), pergolide, pindolol, propranolol, sparfloxacin, selective serotonin reuptake inhibitor (SSRI) antidepressants (eg, fluoxetine, paroxetine, fluvoxamine), streptogramins (eg, dalfopristin), or medicines that may affect your heartbeat. Ask your doctor or pharmacist if you are unsure if any of your medicines may affect your heartbeat you are taking disulfiram or metronidazole, or you have taken fluorouracil within the past 7 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Thioridazine Concentrate:

Some medical conditions may interact with Thioridazine Concentrate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of heart problems (eg, slow heartbeat), high or low blood pressure, blood problems (eg, porphyria), bone marrow problems (eg, low blood platelet levels, low white blood cell count), liver problems (eg, cirrhosis), kidney problems, enlarged prostate gland, seizures or epilepsy, Parkinson disease, Reye syndrome, or a history of breast cancer if you have increased pressure in the eyes or glaucoma, or if you are at risk for glaucoma if you are regularly exposed to extreme heat or phosphorus insecticides if you have a history of alcohol abuse or if you drink more than 3 alcohol-containing drinks per day

Some MEDICINES MAY INTERACT with Thioridazine Concentrate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticholinergics (eg, atropine) because they may decrease the effectiveness of Thioridazine Concentrate Antiarrhythmics (eg, amiodarone, quinidine), arsenic, beta blockers (eg, propranolol), cisapride, dofetilide, droperidol, H1 antagonists (eg, astemizole, terfenadine ), haloperidol, ketolides (eg, telithromycin), macrolide antibiotics (eg, erythromycin), pimozide, pindolol, quinolones (eg, sparfloxacin, levofloxacin), serotonin norepinephrine reuptake inhibitors (eg, duloxetine), serotonin receptor antagonist antiemetics (eg, dolasetron), SSRI antidepressants (eg, fluoxetine, paroxetine, fluvoxamine), streptogramins (eg, dalfopristin), ziprasidone, or other medicines that may affect your heartbeat because risk of severe and possibly fatal side effects, including severe irregular heartbeat, may be increased. Ask your doctor or pharmacist if you are unsure if any of your medicines may affect your heartbeat. Disulfiram , fluorouracil, or metronidazole because the risk of side effects, including headache, fast or irregular heartbeat, nausea, vomiting, and trouble breathing, may be increased Atropine, barbiturates (eg, phenobarbital), narcotics (eg, codeine), or tricyclic antidepressants (eg, amitriptyline) because risk of side effects may be increased by Thioridazine Concentrate Guanethidine, levodopa, or pergolide because their effectiveness may be decreased by Thioridazine Concentrate

This may not be a complete list of all interactions that may occur. Ask your health care provider if Thioridazine Concentrate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Thioridazine Concentrate:

Use Thioridazine Concentrate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Thioridazine Concentrate may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Use the dropper that comes with Thioridazine Concentrate to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose. Thioridazine Concentrate may be mixed with distilled water, acidified tap water, or juice just before you take it. Be sure to take your entire dose. Do not store any mixed medicine for use at a future time. Continue to use Thioridazine Concentrate even if you feel well. Do not miss any doses. If you miss a dose of Thioridazine Concentrate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Thioridazine Concentrate.

Important safety information: Thioridazine Concentrate may cause drowsiness, dizziness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Thioridazine Concentrate. Using Thioridazine Concentrate alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks. Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Thioridazine Concentrate. Thioridazine Concentrate will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants. Alcohol, hot weather, exercise, and fever can increase the risk of dizziness, lightheadedness, or fainting. To prevent these effects, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness. Do not become overheated in hot weather or during exercise or other activities because heatstroke may occur. Involuntary and uncontrollable movements may develop with use of Thioridazine Concentrate. Occurrence is highest among the elderly, especially women. The risk of developing these involuntary movements and the likelihood they will become permanent are increased with long-term use and with high doses. However, it is possible to develop these symptoms after short-term treatment at low doses. Contact your doctor at once if any of the following occur: involuntary movements of tongue, face, mouth, or jaw (eg, sticking out of the tongue, puffing of cheeks, puckering of mouth, chewing movements), or involuntary movements of the arms and legs. Neuroleptic malignant syndrome (NMS) is a serious side effect associated with Thioridazine Concentrate. Symptoms include increased body heat; muscle rigidness; altered mental abilities, including lack of response to your surroundings; irregular or fast heartbeat; or sweating. Contact your doctor at once if any of these symptoms occur. Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Thioridazine Concentrate. Thioridazine Concentrate may cause false results in some pregnancy tests. Check with your doctor if you have any questions or concerns. Make sure your doctor and laboratory personnel know you are using Thioridazine Concentrate. LAB TESTS, including heart function tests and blood potassium levels,, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments. Use Thioridazine Concentrate with caution in the ELDERLY because they may be more sensitive to its effects, especially dizziness, lightheadedness (especially upon standing), involuntary muscle movements, and blood problems (low white blood cell levels). PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Thioridazine Concentrate during pregnancy. Thioridazine Concentrate is excreted in breast milk. Do not breast-feed while taking Thioridazine Concentrate.

If you suddenly stop taking Thioridazine Concentrate, especially if you have been taking high doses, you may experience WITHDRAWAL symptoms, including nausea, vomiting, dizziness, and tremors.

Possible side effects of Thioridazine Concentrate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Agitation; bizarre dreams; constipation; diarrhea; dizziness; drowsiness; dry mouth; loss of appetite; nausea; stuffy nose; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in menstrual period; changes in sexual ability; chest pain; confusion; dark urine; difficulty swallowing; drooling; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hyperactivity; involuntary movements or spasms of the arms, legs, tongue, face, mouth, or jaw; mask-like face; muscle restlessness; restlessness; seizures; severe or persistent dizziness; severe constipation; shuffling walk; sleeplessness; sore mouth or gums; stiff or rigid muscles; stomach pain; sweating; swelling of the hands or feet; trouble urinating; unusual bruising or bleeding; unusual eye movements or inability to move eyes; unusual mood or mental changes, including lack of response to your surroundings; vision changes; weakness of arms or legs; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Thioridazine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; fast, slow, or irregular heartbeat; muscle spasms; restlessness; seizures; severe drowsiness; shortness of breath; tremors; trouble urinating; twitching.

Proper storage of Thioridazine Concentrate:

Store Thioridazine Concentrate at room temperature, below 86 degrees F (30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Thioridazine Concentrate out of the reach of children and away from pets.

General information: If you have any questions about Thioridazine Concentrate, please talk with your doctor, pharmacist, or other health care provider. Thioridazine Concentrate is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. If using Thioridazine Concentrate for an extended period of time, obtain refills before your supply runs out. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Thioridazine Concentrate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Thioridazine resources Thioridazine Side Effects (in more detail) Thioridazine Use in Pregnancy & Breastfeeding Drug Images Thioridazine Drug Interactions Thioridazine Support Group 1 Review for Thioridazine - Add your own review/rating Compare Thioridazine with other medications Schizophrenia

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Dobutamine Concentrate 250 mg / 20 ml.

Dobutamine Concentrate

Important information about your medicine Your doctor or nurse will give you the injection If this injection causes you any problems talk to your doctor, nurse or pharmacist Please tell your doctor or pharmacist, if you have any other medical conditions or have an allergy to any of the ingredients of this medicine Please tell your doctor or pharmacist, if you are taking any other medicines Read all of this leaflet carefully before you start using this medicine. In some circumstances this may not be possible and this leaflet will be kept in a safe place should you wish to read it. Keep this leaflet. You may need to read it again If you have any further questions, please ask your doctor or your pharmacist. This medicine has been prescribed for you personally and you should not pass it on to others. It may harm them, even if their symptoms are the same as yours. Where to find information in this leaflet 1. What Dobutamine Concentrate is and what it is used for 2. Before you are given Dobutamine Concentrate 3. How to use Dobutamine Concentrate 4. Possible side effects 5. Storing Dobutamine Concentrate 6. Further information What Dobutamine Concentrate is and what it is used for

Dobutamine Concentrate belongs to a group of medicines known as inotropes, which make your heart beat more strongly. It is used:

in open heart surgery to treat heart disease to treat heart failure in shock as an alternative to exercise for stress testing the heart. Before you are given Dobutamine Concentrate You should NOT be given Dobutamine Concentrate if you: Are sensitive or allergic to Dobutamine Concentrate, sodium metabisulphite or any of the other ingredients in this injection. suffer from high blood pressure due to a tumour near the kidney (Phaeocromocytoma). Please tell your doctor or nurse before being given the injection if you: have recently had a heart attack are asthmatic have unstable angina have heart disease have high blood pressure have any condition that would make exercise dangerous for you. Using other medicines:

Please tell your doctor or nurse if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. This is especially important with the following medicines as they may interact with your Dobutamine Concentrate:

beta blockers (medicines used to relieve certain heart conditions, anxiety and migraine). anaesthetics. entacapone (a medicine to treat Parkinson’s Disease). Pregnancy or breast feeding:

Please tell your doctor or nurse before being given this injection if you are pregnant or breast feeding. The doctor will then decide if the injection is suitable for you.

Driving and using machines:

You should not drive or use machinery if you are affected by the administration of Dobutamine Concentrate.

How to use Dobutamine Concentrate

Your nurse or doctor will give you the injection.

Your doctor will decide the correct dosage for you and how and when the injection will be given. Dobutamine Concentrate is not normally given to children.

Since the injection will be given to you by a doctor or nurse, it is unlikely that you will be given too much. If you think you have been given too much, feel sick, are sick, feel anxious, feel palpitations, have a headache, feel short of breath or have chest pain you must tell the person giving you the injection.

Possible side effects

Like all medicines, Dobutamine Concentrate can cause side effects, although not everybody gets them.

Intravenous infusions may cause inflammation of the vein and damage to the skin at the injection site. The surrounding skin may feel warm and tender and redness may be present.

Death due to rupture of the heart muscle has occurred very rarely after giving dobutamine to assess the response of the heart to stress in patients with a recent heart attack. Your doctor will examine your heart before giving you Dobutamine Concentrate to decide if you are suitable to receive the drug.

The following side-effects have been reported: Hypersensitivity reactions involving rash and difficulty breathing including life threatening asthmatic episodes Changes in the levels of certain chemicals in the blood. Increased heart rate, palpitations, chest pain and changes to the rhythm of your heart. Changes to your blood pressure including both an increase and a decrease. difficulty in breathing (your breathing may stop) asthma headache nausea (feeling sick) Sudden, involuntary twitching of a muscle or group of muscles.

If you think this injection is causing you any problems, or you are at all worried, talk to your doctor, nurse or pharmacist.

Storing Dobutamine Concentrate

Your injection will be stored at less than 21°C and protected from light. The nurse or doctor will check that the injection is not past its expiry date before giving you the injection.

Further information What Dobutamine Concentrate contains:

This injection contains the active ingredient dobutamine hydrochloride. Each 1 ml contains dobutamine hydrochloride equivalent to 12.5 mg dobutamine in a sterile solution for injection.

This injection contains the following inactive ingredients: sodium metabisulphite, sodium hydroxide, hydrochloric acid, sterile water for injections and carbon dioxide.

What Dobutamine Concentrate looks like and contents of the pack:

Dobutamine Concentrate is supplied in 20 ml clear glass ampoules, in cartons containing one, five or ten ampoules. Not all sizes may be marketed.

The marketing authorisation number of this medicine is: PL 01502/0054

Marketing Authorisation Holder: hameln pharmaceuticals ltd Gloucester United Kingdom Manufacturer: hameln pharmaceuticals gmbh Langes Feld 13 31789 Hameln Germany

For any information about this medicine, please contact the Marketing Authorisation Holder

This leaflet was last approved 12.08.2008

43821/20/09

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Maalox Concentrate

Pronunciation: a-LOO-min-uhm/mag-NEE-zee-uhm
Generic Name: Aluminum/Magnesium
Brand Name: Examples include Alamag and Maalox
Maalox Concentrate is used for:

Treating acid indigestion, heartburn, and sour stomach. It may also be used for other conditions as determined by your doctor.

Maalox Concentrate is an antacid. It works by neutralizing acid in the stomach.

Do NOT use Maalox Concentrate if: you are allergic to any ingredient in Maalox Concentrate you are also taking citrate salts (found in some calcium supplements, antacids, and laxatives)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Maalox Concentrate:

Some medical conditions may interact with Maalox Concentrate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have Alzheimer disease, appendicitis, diarrhea, a stomach blockage, kidney problems, or an ileostomy if you have recently had stomach bleeding

Some MEDICINES MAY INTERACT with Maalox Concentrate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Cation exchange resins (eg, sodium polystyrene sulfonate) and citrate salts (found in some calcium supplements, antacids, and laxatives) because they may increase the actions and the risk of Maalox Concentrate's side effects Anticoagulants (eg, warfarin), quinidine, or sulfonylureas (eg, glyburide) because their actions and the risk of their side effects may be increased Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), beta-blockers (eg, propranolol), bisphosphonates (eg, risedronate), cephalosporins (eg, cephalexin), corticosteroids (eg, hydrocortisone), cyclosporine, delavirdine, digoxin, imidazoles (eg, ketoconazole), mycophenolate, penicillamine, quinolones (eg, ciprofloxacin), tetracyclines (eg, doxycycline), or thyroid hormones (eg, levothyroxine) because their effectiveness may be decreased by Maalox Concentrate, especially when taken at the same time as Maalox Concentrate

This may not be a complete list of all interactions that may occur. Ask your health care provider if Maalox Concentrate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Maalox Concentrate:

Use Maalox Concentrate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Maalox Concentrate by mouth with or without food. Shake well before each use. Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose. Do not use Maalox Concentrate within 2 hours before or after taking a beta-blocker (eg, propranolol), bisphosphonate (eg, risedronate), cephalosporin (eg, cephalexin), corticosteroid (eg, hydrocortisone), delavirdine, digoxin, imidazole (eg, ketoconazole), penicillamine, or sulfonylurea (eg, glyburide) because their effectiveness may be decreased by Maalox Concentrate. If you miss a dose of Maalox Concentrate and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Maalox Concentrate.

Important safety information: Do NOT take more than the recommended dose or take the maximum dose for longer than 2 weeks without checking with your doctor. If your symptoms do not get better within 2 weeks or if they get worse, or if you experience black, tarry stools or vomit that looks like coffee grounds, check with your doctor. Maalox Concentrate has aluminum and magnesium in it. Before you begin taking any new prescription or over-the-counter medicine, read the ingredients to see has aluminum or magnesium in it too. If it does or if you are not sure, check with your doctor or pharmacist. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Maalox Concentrate while you are pregnant. If you are or will be breast-feeding while you use Maalox Concentrate, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Maalox Concentrate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); loss of appetite; muscle weakness; nausea; slow reflexes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Maalox Concentrate:

Store Maalox Concentrate between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Maalox Concentrate out of the reach of children and away from pets.

General information: If you have any questions about Maalox Concentrate, please talk with your doctor, pharmacist, or other health care provider. Maalox Concentrate is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Maalox Concentrate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Maalox resources Maalox Use in Pregnancy & BreastfeedingMaalox Drug InteractionsMaalox Support Group0 Reviews for Maalox - Add your own review/rating Compare Maalox with other medications Duodenal UlcerErosive EsophagitisGERDIndigestionStress Ulcer ProphylaxisZollinger-Ellison Syndrome

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Alamag Concentrate

Pronunciation: a-LOO-min-uhm/mag-NEE-zee-uhm
Generic Name: Aluminum/Magnesium
Brand Name: Examples include Alamag and Maalox
Alamag Concentrate is used for:

Treating acid indigestion, heartburn, and sour stomach. It may also be used for other conditions as determined by your doctor.

Alamag Concentrate is an antacid. It works by neutralizing acid in the stomach.

Do NOT use Alamag Concentrate if: you are allergic to any ingredient in Alamag Concentrate you are also taking citrate salts (found in some calcium supplements, antacids, and laxatives)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Alamag Concentrate:

Some medical conditions may interact with Alamag Concentrate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have Alzheimer disease, appendicitis, diarrhea, a stomach blockage, kidney problems, or an ileostomy if you have recently had stomach bleeding

Some MEDICINES MAY INTERACT with Alamag Concentrate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Cation exchange resins (eg, sodium polystyrene sulfonate) and citrate salts (found in some calcium supplements, antacids, and laxatives) because they may increase the actions and the risk of Alamag Concentrate's side effects Anticoagulants (eg, warfarin), quinidine, or sulfonylureas (eg, glyburide) because their actions and the risk of their side effects may be increased Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), beta-blockers (eg, propranolol), bisphosphonates (eg, risedronate), cephalosporins (eg, cephalexin), corticosteroids (eg, hydrocortisone), cyclosporine, delavirdine, digoxin, imidazoles (eg, ketoconazole), mycophenolate, penicillamine, quinolones (eg, ciprofloxacin), tetracyclines (eg, doxycycline), or thyroid hormones (eg, levothyroxine) because their effectiveness may be decreased by Alamag Concentrate, especially when taken at the same time as Alamag Concentrate

This may not be a complete list of all interactions that may occur. Ask your health care provider if Alamag Concentrate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Alamag Concentrate:

Use Alamag Concentrate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Alamag Concentrate by mouth with or without food. Shake well before each use. Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose. Do not use Alamag Concentrate within 2 hours before or after taking a beta-blocker (eg, propranolol), bisphosphonate (eg, risedronate), cephalosporin (eg, cephalexin), corticosteroid (eg, hydrocortisone), delavirdine, digoxin, imidazole (eg, ketoconazole), penicillamine, or sulfonylurea (eg, glyburide) because their effectiveness may be decreased by Alamag Concentrate. If you miss a dose of Alamag Concentrate and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Alamag Concentrate.

Important safety information: Do NOT take more than the recommended dose or take the maximum dose for longer than 2 weeks without checking with your doctor. If your symptoms do not get better within 2 weeks or if they get worse, or if you experience black, tarry stools or vomit that looks like coffee grounds, check with your doctor. Alamag Concentrate has aluminum and magnesium in it. Before you begin taking any new prescription or over-the-counter medicine, read the ingredients to see has aluminum or magnesium in it too. If it does or if you are not sure, check with your doctor or pharmacist. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Alamag Concentrate while you are pregnant. If you are or will be breast-feeding while you use Alamag Concentrate, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Alamag Concentrate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); loss of appetite; muscle weakness; nausea; slow reflexes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Alamag side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Alamag Concentrate:

Store Alamag Concentrate between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Alamag Concentrate out of the reach of children and away from pets.

General information: If you have any questions about Alamag Concentrate, please talk with your doctor, pharmacist, or other health care provider. Alamag Concentrate is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Alamag Concentrate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Alamag resources Alamag Side Effects (in more detail)Alamag Use in Pregnancy & BreastfeedingAlamag Drug InteractionsAlamag Support Group0 Reviews for Alamag - Add your own review/rating Compare Alamag with other medications Duodenal UlcerErosive EsophagitisGERDIndigestionStress Ulcer ProphylaxisZollinger-Ellison Syndrome

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Osteopenia Medications

Drugs associated with Osteopenia

The following drugs and medications are in some way related to, or used in the treatment of Osteopenia. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Drug List: Cal-Gest Calcarb Calci-Mix Calci-Chew Calcium-Concentrate Calcium-Liquid-Softgel Calcium-Oyster-Shell Caltrate Nephro-Calci Os-Cal-500 Oysco-500 Oyst-Cal-500 Oyster-Cal Oyster-Calcium Oyster-Shell Tums-Kids-Chewable-Tablets

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Sterile Potassium Chloride Concentrate 15% (hameln)

Read all of this leaflet carefully before you start taking this medicine. Keep this leaflet. You may need to read it again. If you have further questions, please ask your doctor or your pharmacist. This medicine has been prescribed for you personally and you should not pass it on to others. It may harm them, even if their symptoms are the same as yours. In this leaflet: 1. What your medicine is and what it is used for 2. Before you receive it 3. How it is administered 4. Possible side effects 5. Storing your injection 6. Use by date Sterile Potassium Chloride Concentrate 15%

Each ml contains 0.15 g potassium chloride in a sterile solution for injection. The other ingredients are hydrochloric acid and water for injections.

Holder of the Marketing Authorisation: hameln pharmaceuticals ltd Gloucester United Kingdom Manufacturer: hameln Pharmaceuticals gmbh Langes Feld 13 31789 Hameln Germany What potassium chloride is and what it is used for

Potassium chloride occurs naturally in your body.

It is used to replace the loss of potassium from your body, if this cannot be achieved when given by mouth or in the diet.

The injection is supplied in clear glass ampoules containing 10 ml.

10 ampoules are supplied in each carton.

Before the injection is given to you

Please tell your doctor, nurse or pharmacist before being given the injection if you:

suffer from impaired kidney function suffer from Addison's disease (a disease characterised by a reduced secretion of hormones from a gland situated near the kidneys) are very dehydrated suffer from heat cramps suffer from disturbances in the salt content of your blood are pregnant or breast-feeding

Please inform your doctor, nurse or pharmacist if you are taking or have recently taken any other medicines, even those not prescribed, especially diuretics (water tablets) as these may interfere with this injection.

How the injection is given to you

Your doctor, nurse or pharmacist will give you the injection.

Sterile Potassium Chloride Concentrate 15% may be given by an intravenous injection (into a vein).

In emergencies, it may be necessary to give the injection without your knowledge.

Your doctor will decide on the correct dosage for you and when or how the injection will be given.

The injection must be diluted at least 50 times before it is given to you.

Possible side effects

Like all medicines, potassium chloride can have side effects.

Potassium chloride may cause the following side effects:

pain at the site of injection inflammation of the vein into which the solution is being injected raised blood levels of potassium

If you experience these or any other side effects not mentioned in this leaflet, please inform your doctor, nurse or pharmacist

Storing your injection

Your injection will be stored under 25°C, protected from light and out of the reach and sight of children.

Use by date

The doctor, nurse or pharmacist will check that the injection is not past its expiry date before giving you the injection.

This leaflet was last updated on March 25th 2004.

PL01502/0007R

43856/19/04

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Chlorpromazine Concentrate

Pronunciation: klor-PROE-ma-zeen
Generic Name: Chlorpromazine
Brand Name: Generic only. No brands available.

Chlorpromazine Concentrate is an antipsychotic. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Chlorpromazine Concentrate is not approved to treat mental problems caused by dementia. Discuss any questions or concerns with your doctor.

Chlorpromazine Concentrate is used for:

Treating certain mental or mood disorders (eg, schizophrenia), the manic phase of manic-depressive disorder, anxiety and restlessness before surgery, the blood disease porphyria, severe behavioral and conduct disorders in children, nausea and vomiting, and severe hiccups. It is also used with other medicines to treat symptoms associated with tetanus. It may also be used for other conditions as determined by your doctor.

Chlorpromazine Concentrate is a phenothiazine. Exactly how it works is not known.

Do NOT use Chlorpromazine Concentrate if: you are allergic to any ingredient in Chlorpromazine Concentrate or to other phenothiazines (eg, thioridazine) you have severe drowsiness you have recently taken large amounts of alcohol or medicines that may cause drowsiness, such as barbiturates (eg, phenobarbital) or narcotic pain medicines (eg, codeine) you are taking certain antiarrhythmic medicines (eg, amiodarone, dofetilide, dronedarone, quinidine, sotalol), cisapride, pergolide, pimozide, quetiapine, or ziprasidone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Chlorpromazine Concentrate:

Some medical conditions may interact with Chlorpromazine Concentrate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of heart problems, low blood pressure, blood problems, bone marrow problems, low white blood cell count, diabetes, liver problems (eg, cirrhosis), kidney problems, neuroleptic malignant syndrome (NMS), an enlarged prostate gland, seizures or epilepsy, or an adrenal gland tumor (pheochromocytoma) if you have asthma, lung infection, or other lung problems (eg, emphysema); increased pressure in the eyes; glaucoma; or if you are at risk for glaucoma if you have Alzheimer disease, dementia, Parkinson disease, or Reye syndrome if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary, brain), or if you are at risk of breast cancer if you are regularly exposed to extreme heat or organophosphate insecticides if you have a history of alcohol abuse or if you consume more than 3 alcoholic drinks per day

Some MEDICINES MAY INTERACT with Chlorpromazine Concentrate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Lithium because the risk of a severe and sometimes permanent nervous system problem (encephalopathic syndrome) characterized by weakness, lethargy, fever, tremor, confusion, or uncontrolled muscle movements may be increased Certain antiarrhythmic medicines (eg, amiodarone, dofetilide, dronedarone, quinidine , sotalol), cisapride, pergolide, pimozide, quetiapine, or ziprasidone because the risk of side effects, such as racing heartbeat, dizziness, fainting, and life-threatening irregular heartbeat leading to unconsciousness, may be increased by Chlorpromazine Concentrate Many prescription and nonprescription medicines (eg, used for allergies, blood clotting problems, cancer, infections, inflammation, aches and pains, heart problems, high blood pressure, high cholesterol, mental or mood problems, nausea or vomiting, Parkinson disease, seizures, stomach problems), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, gingko, St. John's wort) may interact with Chlorpromazine Concentrate, increasing the risk of side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Chlorpromazine Concentrate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Chlorpromazine Concentrate:

Use Chlorpromazine Concentrate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Chlorpromazine Concentrate by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose. Mix your dose in water or juice just before taking it. You may mix Chlorpromazine Concentrate with tomato or fruit juice, milk, simple syrup, orange syrup, carbonated beverages, coffee, tea, or water. Semisolid foods (eg, soups, puddings) may also be used. If you miss a dose of Chlorpromazine Concentrate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Chlorpromazine Concentrate.

Important safety information: Chlorpromazine Concentrate may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Chlorpromazine Concentrate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Do not drink alcohol while you are using Chlorpromazine Concentrate. Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Chlorpromazine Concentrate; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. Chlorpromazine Concentrate may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Do not become overheated in hot weather or while you are being active; heatstroke may occur. Chlorpromazine Concentrate may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Chlorpromazine Concentrate. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. Chlorpromazine Concentrate may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills. Some patients who take Chlorpromazine Concentrate may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Chlorpromazine Concentrate in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Chlorpromazine Concentrate. Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Chlorpromazine Concentrate. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms. Tell your doctor or dentist that you take Chlorpromazine Concentrate before you receive any medical or dental care, emergency care, or surgery. Chlorpromazine Concentrate may increase the amount of a certain hormone (prolactin) in your blood. Symptoms may include enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge. Contact your doctor right away if you experience any of these symptoms. Chlorpromazine Concentrate may raise or lower your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. If these symptoms occur, tell your doctor right away. Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Chlorpromazine Concentrate may cause the results of some pregnancy tests to be wrong. Check with your doctor if you have questions or concerns about your pregnancy test results. Chlorpromazine Concentrate may interfere with certain lab tests, including phenylketonuria (PKU) tests. Be sure your doctor and lab personnel know you are taking Chlorpromazine Concentrate. Lab tests, including liver function, complete blood cell counts, and eye exams, may be performed while you use Chlorpromazine Concentrate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Use Chlorpromazine Concentrate with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness, light-headedness (especially upon standing), rapid heartbeat, breathing problems, urinary retention, and constipation. Chlorpromazine Concentrate should not be used in CHILDREN younger than 6 months old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Chlorpromazine Concentrate while you are pregnant. Using Chlorpromazine Concentrate during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. Chlorpromazine Concentrate is found in breast milk. Do not breast-feed while taking Chlorpromazine Concentrate.

If you suddenly stop taking Chlorpromazine Concentrate, you may experience WITHDRAWAL symptoms, including nausea, vomiting, dizziness, and tremors.

Possible side effects of Chlorpromazine Concentrate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Agitation; constipation; dizziness; drowsiness; dry mouth; enlarged pupils; jitteriness; nausea; stuffy nose.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in menstrual period; changes in sexual ability; confusion; dark urine; difficulty swallowing; drooling; fainting; fast or irregular heartbeat; fever, chills, or sore throat; involuntary movements or spasms of the arms and legs, tongue, face, mouth, or jaw; mask-like face; muscle restlessness; prolonged or painful erection; restlessness; seizures; severe constipation; severe or persistent dizziness; shuffling walk; sleeplessness; stiff or rigid muscles; stomach pain; sweating; tremor; trouble urinating; unusual bruising or bleeding; unusual eye movements or inability to move your eyes; unusual mood or mental changes, including lack of response to your surroundings; unusual tiredness or weakness; unusually pale skin; vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Chlorpromazine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; fainting; involuntary movements or muscle spasms; irregular heartbeat; light-headedness; loss of consciousness; restlessness; seizures; severe drowsiness or dizziness; tremors; twitching.

Proper storage of Chlorpromazine Concentrate:

Store Chlorpromazine Concentrate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Chlorpromazine Concentrate out of the reach of children and away from pets.

General information: If you have any questions about Chlorpromazine Concentrate, please talk with your doctor, pharmacist, or other health care provider. Chlorpromazine Concentrate is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. If using Chlorpromazine Concentrate for an extended period of time, obtain refills before your supply runs out. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Chlorpromazine Concentrate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Chlorpromazine resources Chlorpromazine Side Effects (in more detail) Chlorpromazine Use in Pregnancy & Breastfeeding Drug Images Chlorpromazine Drug Interactions Chlorpromazine Support Group 8 Reviews for Chlorpromazine - Add your own review/rating Compare Chlorpromazine with other medications Hiccups Light Sedation Mania Nausea/Vomiting Opiate Withdrawal Porphyria Psychosis Schizophrenia Tetanus

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Seizure Prevention (Seizure Prophylaxis) Medications

Drugs associated with Seizure Prevention

The following drugs and medications are in some way related to, or used in the treatment of Seizure Prevention. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Drug List: Depacon Depakene Diamox Diamox-Sequels-Sustained-Release-Capsules Diastat-Gel Diastat-Acudial-Gel Diastat-Pediatric Diazepam-Intensol-Concentrate Epsom-Salt Klonopin Klonopin-Wafer-Orally-Disintegrating-Tablets Lamictal Lamictal-Cd Lamictal-Odt-Orally-Disintegrating-Tablets Lamictal-Xr-Extended-Release-Tablets Mesantoin Paradione Peganone Sabril Stavzor Sulfamag Topamax Topamax-Sprinkle Topiragen Tranxene Tranxene-Sd-Sustained-Release-Tablets Tranxene-T-Tab Tridione Valium Valrelease

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Methadose Concentrate

Pronunciation: METH-a-done
Generic Name: Methadone
Brand Name: Methadose

Methadose Concentrate may cause severe and sometimes fatal heart and breathing problems. These problems may occur some time after you take a dose. Tell your doctor right away if you develop any new or worsening symptoms such as slowed or shallow breathing or irregular heartbeat. Your doctor will perform heart and lung function tests to check for side effects while you take Methadose Concentrate. Keep all doctor and laboratory appointments. Talk with your doctor and be sure you understand the risks and benefits of using Methadose Concentrate.

Do not take more than the recommended dose or take Methadose Concentrate more often than prescribed. This can lead to overdose and possible death.

Methadose Concentrate is used for:

Treating a narcotic addiction as part of a treatment program. It may also be used for other conditions as determined by your doctor.

Methadose Concentrate is a narcotic analgesic. It works by acting on opiate pain receptors in the brain and on smooth muscle to provide pain relief.

Do NOT use Methadose Concentrate if: you are allergic to any ingredient in Methadose Concentrate you have slowed breathing or severe asthma, or if you are having an asthma attack you have a stomach or bowel blockage or certain severe bowel problems (eg, paralytic ileus) you have diarrhea caused by food poisoning or antibiotic use you are taking sodium oxybate (GHB) if you have taken a monamine oxidase inhibitor type B (MAOI-B) (eg, rasagiline, selegiline) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Methadose Concentrate:

Some medical conditions may interact with Methadose Concentrate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have lung or breathing problems (eg, asthma), chronic obstructive pulmonary disease (COPD), sleep apnea, stomach or bowel problems (eg, bowel inflammation), stomach pain or constipation, liver or kidney problems, thyroid problems, or Addison disease if you have an abnormal curvature of the spine; narrowing of the urethra, trouble urinating, or an enlarged prostate; low blood volume, blood pressure, or blood oxygen levels; low potassium or magnesium blood levels; increased pressure, tumors, or lesions in your head; a recent head injury; or seizures if you have a history of heart problems (eg, enlarged heart) or irregular heartbeat if you or a family member have a history of mental or mood problems (eg, anxiety, depression), suicidal thoughts or attempts, or alcohol or substance abuse if you are elderly, very ill, or very overweight, or if you have recently had stomach or intestine surgery

Some MEDICINES MAY INTERACT with Methadose Concentrate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Barbiturate anesthetics (eg, thiopental), benzodiazepines (eg, midazolam), cimetidine, MAOI-B (eg, rasagiline, selegiline), other narcotic analgesics (eg, morphine), phenothiazines (eg, promethazine), or sodium oxybate (GHB) because side effects such as sedation and slowed breathing may occur Antiarrhythmics (eg, amiodarone, dofetilide, flecainide, propafenone), antipsychotics (eg, haloperidol, paliperidone, ziprasidone), calcium channel blockers (eg, nifedipine), certain antiemetics (eg, dolasetron, droperidol), chloroquine, cisapride, diuretics (eg, furosemide), H1 antagonists (eg, astemizole), kinase inhibitors (eg, lapatinib, nilotinib), lithium, macrolide antibiotics (eg, clarithromycin), phenothiazines (eg, chlorpromazine), quinolones (eg, ciprofloxacin), streptogramins (eg, quinupristin), tacrolimus, or tricyclic antidepressants (eg, desipramine) because the risk of QT prolongation may be increased Azole antifungals (eg, fluconazole, ketoconazole, voriconazole) or certain selective serotonin reuptake inhibitors (SSRIs) (eg, fluvoxamine, sertraline) because they may increase the risk of Methadose Concentrate's side effects Abacavir, carbamazepine, efavirenz, HIV protease inhibitors (eg, amprenavir, lopinavir, nelfinavir, ritonavir), narcotic agonists/antagonists (eg, butorphanol, nalbuphine, pentazocine), narcotic antagonists (eg, naloxone, naltrexone), nevirapine, phenobarbital, phenytoin, rifampin, or St. John's wort because they may decrease Methadose Concentrate's effectiveness Zidovudine because the risk of its side effects may be increased by Methadose Concentrate Nucleoside reverse transcriptase inhibitors (NRTIs) (eg, abacavir, didanosine, stavudine) because their effectiveness may be decreased by Methadose Concentrate

This may not be a complete list of all interactions that may occur. Ask your health care provider if Methadose Concentrate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Methadose Concentrate:

Use Methadose Concentrate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Methadose Concentrate by mouth with or without food. Methadose Concentrate is for oral use only and must not be injected. Methadose Concentrate must be administered under close medical supervision. Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose. Methadose Concentrate must be mixed with water or other liquid before you use it. Follow your doctor's instructions on how to mix Methadose Concentrate. Take Methadose Concentrate on a regular schedule to get the most benefit from it. If Methadose Concentrate is no longer needed, dispose of it as soon as possible. Ask your doctor or pharmacist how to dispose of Methadose Concentrate properly. Always keep Methadose Concentrate in a secure place to protect from theft. If you miss a dose of Methadose Concentrate and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss your doses of Methadose Concentrate for more than 2 days, contact your doctor before you start taking Methadose Concentrate again.

Ask your health care provider any questions you may have about how to use Methadose Concentrate.

Important safety information: Methadose Concentrate may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Methadose Concentrate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Methadose Concentrate; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. Methadose Concentrate may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Breathing problems may occur some time after you take a dose of Methadose Concentrate. Tell your doctor or seek medical care immediately if you notice trouble breathing (eg, slowed or shallow breathing) while you take Methadose Concentrate. Methadose Concentrate may cause constipation. Constipation may be avoided by using a stool softener or fiber laxative. The risk of Methadose Concentrate becoming habit-forming may be greater if you take it in high doses or for a long time. Do NOT take more than the recommended dose or use Methadose Concentrate for longer than prescribed without talking with your doctor. Tell your doctor or dentist that you take Methadose Concentrate before you receive any medical or dental care, emergency care, or surgery. Lab tests, including liver function, lung function, and heart function, may be performed while you use Methadose Concentrate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Use Methadose Concentrate with caution in the ELDERLY; they may be more sensitive to its effects. Methadose Concentrate should not be used in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: Methadose Concentrate may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Methadose Concentrate while you are pregnant. Methadose Concentrate is found in breast milk. If you are or will be breast-feeding while you use Methadose Concentrate, check with your doctor. Discuss any possible risks to your baby.

When used for long periods of time or at high doses, Methadose Concentrate may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Methadose Concentrate stops working well. Do not take more than prescribed.

Some people who use Methadose Concentrate for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.

If you stop taking Methadose Concentrate suddenly, you may have WITHDRAWAL symptoms. These may include convulsions, tremor, stomach and muscle cramps, vomiting, and sweating. Do not stop therapy suddenly or change the dosage without asking your doctor. Discuss overuse with your doctor or pharmacist.

Possible side effects of Methadose Concentrate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth; headache; increased sweating; itching; lightheadedness; nausea; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; decreased sexual desire or ability; excessive drowsiness; fainting; fast, slow, or irregular heartbeat; hallucinations; loss of appetite; menstrual changes; mental or mood changes (eg, agitation, disorientation, exaggerated sense of well-being); seizures; severe or persistent dizziness or lightheadedness; shortness of breath; slow or shallow breathing; swelling of the arms, feet, or legs; trouble sleeping; trouble urinating; unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Methadose side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include cold and clammy skin; coma; fainting; fast, slow, or irregular heartbeat; muscle weakness; pinpoint pupils; severe dizziness, drowsiness, or lightheadedness; slow, shallow, or difficult breathing.

Proper storage of Methadose Concentrate:

Store Methadose Concentrate at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Methadose Concentrate out of the reach of children and away from pets.

General information: If you have any questions about Methadose Concentrate, please talk with your doctor, pharmacist, or other health care provider. Methadose Concentrate is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Methadose Concentrate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Methadose resources Methadose Side Effects (in more detail) Methadose Use in Pregnancy & Breastfeeding Drug Images Methadose Drug Interactions Methadose Support Group 21 Reviews for Methadose - Add your own review/rating Compare Methadose with other medications Opiate Withdrawal Pain

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Prednisone Concentrate

Pronunciation: PRED-ni-sone
Generic Name: Prednisone
Brand Name: Generics only. No brands available.
Prednisone Concentrate is used for:

Treating severe allergies, arthritis, asthma, multiple sclerosis, and skin conditions. It may also be used for other conditions as determined by your doctor.

Prednisone Concentrate is a corticosteroid. It works by decreasing or preventing tissues from responding to inflammation. It also modifies the body's response to certain immune stimulation.

Do NOT use Prednisone Concentrate if: you are allergic to any ingredient in Prednisone Concentrate you have a systemic fungal infection you are currently taking mifepristone or disulfiram

Contact your doctor or health care provider right away if any of these apply to you.

Before using Prednisone Concentrate:

Some medical conditions may interact with Prednisone Concentrate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you are scheduled for a vaccination with a live virus vaccine (eg, smallpox) if you have an underactive thyroid, liver or kidney problems, diabetes, or ulcerative colitis if you have heart problems, esophagitis, gastritis, stomach obstruction or perforation, or an ulcer if you have a history of mental problems, such as depression if you have a herpes infection in your eye or any other type of infection (bacterial, fungal, or viral); have or recently had tuberculosis (TB) or tested positive for TB, measles, or chickenpox

Some MEDICINES MAY INTERACT with Prednisone Concentrate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), or rifampin because the effectiveness of Prednisone Concentrate may be decreased Clarithromycin, azole antifungals (eg, ketoconazole), steroidal contraceptives (eg, desogestrel), or troleandomycin because side effects, such as weakness, confusion, muscle aches, joint pain, or low blood sugar, may occur Methotrexate or ritodrine because the actions and side effects of these medicines may be increased Hydantoins (eg, phenytoin), mifepristone, or live vaccines because the effectiveness of these medicines may be decreased Anticoagulants (eg, warfarin) or aspirin because the actions and side effects of these medicines may be increased or decreased Certain cephalosporins (eg, cefotetan), disulfiram, fluorouracil, furazolidone, metronidazole and derivatives (eg, tinidazole), or sulfonylureas (eg, glipizide) because risk of side effects, such as flushing, headache, fast or irregular heartbeat, nausea, or vomiting, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prednisone Concentrate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Prednisone Concentrate:

Use Prednisone Concentrate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Prednisone Concentrate by mouth with food. Use the dropper that comes with Prednisone Concentrate to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose. If you miss a dose of Prednisone Concentrate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prednisone Concentrate.

Important safety information: Patients on long-term steroid therapy should carry an ID card at all times that says they are taking Prednisone Concentrate. Prednisone Concentrate makes you more susceptible to illnesses, especially if you take it for an extended period of time. Prevent infection by avoiding contact with people who have colds or other infections. If you are exposed to chickenpox, measles, or TB while taking Prednisone Concentrate or within 12 months after stopping Prednisone Concentrate, call your doctor. Report any injuries or signs of an infection (fever, sore throat, pain during urination, or muscle aches) that occur during treatment and within 12 months after stopping Prednisone Concentrate. Your dose may need to be adjusted or you may need to start taking Prednisone Concentrate again. Tell your doctor or dentist that you take Prednisone Concentrate before you receive any medical or dental care, emergency care, or surgery. Long-term use may cause cataracts, glaucoma, and eye infections. Prednisone Concentrate may cause an elevation in blood pressure, salt and water retention, and increased potassium loss. You may need to restrict the use of salt and take a calcium supplement. Prednisone Concentrate can cause calcium loss and promote the development of osteoporosis. Take adequate calcium and vitamin D supplements. If you are taking Prednisone Concentrate for a long period of time, do not suddenly stop taking it without checking with your doctor. Do not receive a live vaccine, especially smallpox, while you are taking Prednisone Concentrate. Talk with your doctor before you receive any vaccine. Diabetes patients - Prednisone Concentrate may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Lab tests may be performed while you use Prednisone Concentrate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Infants and CHILDREN on long-term therapy must be closely monitored by a health care provider. Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they take Prednisone Concentrate. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prednisone Concentrate while you are pregnant. Prednisone Concentrate is found in breast milk. If you are or will be breast-feeding while you use Prednisone Concentrate, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Prednisone Concentrate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Difficulty sleeping; feeling of a whirling motion; increased appetite; increased sweating; indigestion; mood changes; nervousness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); appetite loss; black, tarry stools; changes in menstrual periods; convulsions; depression; diarrhea; dizziness; exaggerated sense of well-being; fever; general body discomfort; headache; increased pressure in the eye; joint or muscle pain; mood swings; muscle weakness; personality changes; prolonged sore throat, cold, or fever; puffing of the face; severe nausea or vomiting; swelling of feet or legs; unusual weight gain; vomiting material that looks like coffee grounds; weakness; weight loss.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Prednisone side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Prednisone Concentrate:

Store Prednisone Concentrate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prednisone Concentrate out of the reach of children and away from pets.

General information: If you have any questions about Prednisone Concentrate, please talk with your doctor, pharmacist, or other health care provider. Prednisone Concentrate is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Prednisone Concentrate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Prednisone resources Prednisone Side Effects (in more detail) Prednisone Use in Pregnancy & Breastfeeding Drug Images Prednisone Drug Interactions Prednisone Support Group 86 Reviews for Prednisone - Add your own review/rating Compare Prednisone with other medications Acute Lymphocytic Leukemia Adrenocortical Insufficiency Adrenogenital Syndrome Allergic Reactions Ankylosing Spondylitis Aspiration Pneumonia Asthma Atopic Dermatitis Autoimmune Hemolytic Anemia Berylliosis Bullous Pemphigoid Bursitis Chorioretinitis Cluster Headaches Cogan's Syndrome Conjunctivitis, Allergic Corneal Ulcer Dermatitis Herpetiformis Dermatomyositis Eczema Epicondylitis, Tennis Elbow Erythroblastopenia Fibromyalgia Gouty Arthritis Graft-versus-host disease Hay Fever Herpes Zoster Herpes Zoster Iridocyclitis Hypercalcemia of Malignancy Idiopathic Thrombocytopenic Purpura Immunosuppression Inflammatory Bowel Disease Inflammatory Conditions Iridocyclitis Iritis Juvenile Rheumatoid Arthritis Keratitis Leukemia Lichen Planus Lichen Sclerosus Loeffler's Syndrome Lymphoma Multiple Sclerosis Mycosis Fungoides Nephrotic Syndrome Neurosarcoidosis Osteoarthritis Pemphigoid Pemphigus Pharyngitis Polymyositis/Dermatomyositis Psoriasis Psoriatic Arthritis Rheumatoid Arthritis Sarcoidosis Seborrheic Dermatitis Sinusitis Skin Rash Synovitis Systemic Lupus Erythematosus Systemic Sclerosis Thrombocytopenia Toxic Epidermal Necrolysis Tuberculosis, Extrapulmonary Tuberculous Meningitis Ulcerative Colitis Uveitis, Posterior

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Mellaril-S

Generic Name: thioridazine (THYE oh RID a zeen)
Brand Names:

What is Mellaril-S (thioridazine)?

Thioridazine is an anti-psychotic medication in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain.

Thioridazine is used to treat psychotic disorders such as schizophrenia.

Thioridazine is usually given after other medications have been tried without successful treatment of schizophrenia.

Thioridazine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Mellaril-S (thioridazine)? Stop using this medication and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects. Thioridazine is not for use in psychotic conditions related to dementia. Thioridazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use thioridazine if you have brain damage, bone marrow depression, severe heart disease, a heart rhythm disorder, a history of "Long QT syndrome," or if you are also using large amounts of alcohol or medicines that make you sleepy.

Do not take thioridazine together with large amounts of alcohol or medicines that make you sleepy, or with medications that can affect heart rhythm. There are many medicines that should not be taken together with thioridazine because they may cause serious medical problems. Tell your doctor about all other medications you use.

Before you take thioridazine, tell your doctor if you have heart disease, high blood pressure, a heart rhythm disorder, low levels of calcium or potassium in your blood, past or present breast cancer, liver or kidney disease, severe asthma or breathing problems, a history of seizures, Parkinson's disease, adrenal gland tumor, enlarged prostate or urination problems, glaucoma, or if you have ever had a serious side effect while using thioridazine or a similar medication.

What should I discuss with my healthcare provider before taking Mellaril-S (thioridazine)? Thioridazine is not for use in psychotic conditions related to dementia. Thioridazine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not use thioridazine if you are allergic to it, or if you have brain damage, bone marrow depression, severe heart disease, a heart rhythm disorder, a history of "Long QT syndrome," or if you are also using large amounts of alcohol or medicines that make you sleepy.

There are many medicines that should not be taken together with thioridazine because they may cause serious medical problems. Tell your doctor about all other medications you take, including:

antibiotics;

antidepressants;

blood pressure medications;

medications to treat or prevent malaria;

cancer medications;

certain HIV/AIDS medications;

migraine headache medicine;

heart rhythm medications;

medicine to prevent or treat nausea and vomiting;

certain narcotic pain medicines; and

other anti-psychotic medicines.

To make sure you can safely take thioridazine, tell your doctor if you have any of these other conditions:

heart disease, high blood pressure, or a heart rhythm disorder;

low levels of potassium in your blood (hypokalemia);

past or present breast cancer;

liver or kidney disease;

severe asthma, emphysema, or other breathing problem;

a history of seizures;

Parkinson's disease;

adrenal gland tumor (pheochromocytoma);

enlarged prostate or urination problems;

low levels of calcium in your blood (hypocalcemia);

glaucoma; or

if you have ever had a serious side effect while using thioridazine or another phenothiazine.

It is not known whether thioridazine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking thioridazine, do not stop taking it without your doctor's advice. Thioridazine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take Mellaril-S (thioridazine)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

To be sure this medication is not causing harmful effects, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG). This machine measures electrical activity of the heart. Visit your doctor regularly.

Store thioridazine at room temperature away from moisture, heat, and light. What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include stomach cramps, extreme dizziness, dry skin, decreased urination, uncontrollable muscle movements, confusion, agitation, feeling hot or cold, fast or pounding heartbeat, fainting, slow heart rate, weak or shallow breathing, and seizure (convulsions).

What should I avoid while taking Mellaril-S (thioridazine)? Thioridazine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Drinking alcohol can increase certain side effects of thioridazine. Avoid exposure to sunlight or tanning beds. Thioridazine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Mellaril-S (thioridazine) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using thioridazine and call your doctor at once if you have a serious side effect such as:

fast or pounding heartbeat;

twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;

tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking;

feeling restless, jittery, or agitated;

very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, feeling like you might pass out;

seizure (convulsions);

decreased night vision, tunnel vision, watery eyes, increased sensitivity to light;

pale skin, easy bruising or bleeding, sore throat, flu symptoms;

urinating less than usual or not at all;

nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes);

joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or

slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious side effects may include:

dizziness, drowsiness, anxiety;

dry mouth, stuffy nose, constipation;

blurred vision, headache;

breast swelling or discharge;

changes in your menstrual periods;

weight gain, swelling in your hands or feet;

impotence, trouble having an orgasm;

increased or decreased interest in sex;

sleep problems (insomnia), strange dreams; or

mild itching or skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Mellaril-S (thioridazine)? Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by thioridazine. Tell your doctor if you regularly use any of these medicines, or any other anti-psychotic medications.

atropine (Atreza, Sal-Tropine);

lithium (Eskalith, Lithobid);

an antibiotic;

birth control pills or hormone replacement estrogens;

a blood thinner such as warfarin (Coumadin);

certain asthma medications or bronchodilators;

incontinence medications;

insulin or diabetes medications you take by mouth;

medication for nausea, vomiting, or motion sickness;

medications used for general anesthesia;

numbing medicine such as lidocaine or Novocain;

medicines used to prevent organ transplant rejection;

a stimulant or ADHD medication;

ulcer or irritable bowel medications; or

medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma).

This list is not complete and there are many other drugs that can cause serious or life-threatening medical problems if you take them together with thioridazine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. More Mellaril-S resources Mellaril-S Side Effects (in more detail) Mellaril-S Use in Pregnancy & Breastfeeding Mellaril-S Drug Interactions Mellaril-S Support Group 0 Reviews for Mellaril-S - Add your own review/rating Thioridazine Prescribing Information (FDA) Thioridazine MedFacts Consumer Leaflet (Wolters Kluwer) Compare Mellaril-S with other medications Schizophrenia Where can I get more information? Your pharmacist can provide more information about thioridazine.

See also: Mellaril-S side effects (in more detail)

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Adrenergic bronchodilators

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Adrenergic bronchodilators (specifically beta2-adrenoreceptor agonists) dilate the bronchi by a direct action on the beta2-adrenoreceptors on the bronchial smooth muscle and relax the muscle.

There are two categories of beta2-adrenoreceptor agonists used in asthma. The short acting adrenergic bronchodilators are used on an as needed basis to control symptoms of asthma. The longer acting bronchodilators are used regularly, twice daily, as adjunct therapy in patients whose asthma is poorly controlled by inhaled corticosteroids.

See also

Medical conditions associated with adrenergic bronchodilators:

Adams-Stokes SyndromeAllergic ReactionsAsthmaAsthma, acuteAsthma, MaintenanceAsystoleAV Heart BlockBronchitisBronchospasm During AnesthesiaBronchospasm ProphylaxisCardiac ArrhythmiaCOPDCOPD, AcuteCOPD, MaintenanceElectromechanical DissociationPremature LaborShock Drug List:Epipen-Auto-InjectorIsuprelIsuprel-MistometerForadilSereventXopenex-Hfa-AerosolXopenexBrovanaPrimatene-Mist-AerosolAlupentBricanylMaxairVolmaxXopenex-ConcentrateProventil-Hfa-AerosolBrethineProventilVentolin-Hfa-AerosolMaxair-AutohalerProair-Hfa-AerosolPerforomistVentolinVospire-Er-Extended-Release-TabletsAccuneb-SolutionAdrenaclick-Auto-InjectorAdrenalinAdrenalin-ChlorideAiret-SolutionArcaptaAsthmahaler-AerosolBrethaireBronkometerBronkosolEpipen-2-PakEpipen-Auto-InjectorEpipen-Jr-Auto-InjectorEpipen-Jr-2-PakEpipen-Jr-Auto-InjectorMedihaler-EpiMedihaler-IsoMetaprelTornalateTwinject-Auto-InjectorTwinject-Auto-InjectorTwinject-Auto-Injector-Two-Pack

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Sterile Potassium Chloride Concentrate 20% (hameln)

1. Name Of The Medicinal Product

Sterile Potassium Chloride Concentrate 20%.

2. Qualitative And Quantitative Composition

20% of Potassium Chloride in 5ml.

3. Pharmaceutical Form

Sterile Injection.

4. Clinical Particulars 4.1 Therapeutic Indications

Sterile Potassium Chloride Concentrate 20% is used as a source of the potassium cation for the treatment or prevention of potassium depletion in patients for whom dietary measures or oral medication are inadequate. Potassium salts may also be used cautiously in those taking digoxin where potassium depletion may cause arrhythmias. Sterile Potassium Chloride Concentrate 20% must be administered by slow I.V, as a dilute solution.

4.2 Posology And Method Of Administration

Adults (including elderly) and Children:

Sterile Potassium Chloride Concentrate 20% must be diluted by adding to a large volume of intravenous fluid before use. For example, 10mls diluted with not less than 700mls 0.9% Sodium Chloride Intravenous Infusion BP, or other suitable diluent, and mixed well.

Dosage depends on the serum ionogram value and the acid-base state. A potassium deficiency is calculated according to the formula:

MMOL Potassium = KG BW x 0.2 x 2 x (4.5 – actual serum potassium (MMOL)).

(The extracellular volume is calculated from the body weight in kg x 0.2).

The maximum dosage is 20 MMOL potassium per hour.

It is recommended not to exceed 2-3 MMOL potassium per kg body weight in 24 hours.

4.3 Contraindications

Hyperkalaemia, hyperchloraemia, impaired renal function with oliguria, anuria or azotaemia, Addison's disease, acute dehydration and heat cramps.

4.4 Special Warnings And Precautions For Use

Sterile Potassium Chloride Concentrate 20% must not be injected undiluted.

Plasma potassium concentration must be measured at regular intervals to avoid the development of hyperkalaemia, especially in patients with renal impairment.

ECG monitoring facilities should be available.

Initial potassium replacement therapy should not involve glucose infusions, because glucose may cause a further decrease in the plasma potassium concentration.

Potassium supplements should be administered with caution in patients with cardiac disease and in patients who are receiving potassium sparing diuretics or other medications which may increase plasma potassium levels.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Potassium sparing diuretics:

Potassium supplements should not be administered with potassium- sparing diuretics (such as amiloride, spironolactone and triamterene), particularly in patients with impaired renal function. Any patients on this combination require close monitoring in order to diagnose a potential hyperkalaemic condition as soon as possible.

Angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists:

Patients taking ACE-inhibitors or angiotensin II receptor antagonists, especially those with impaired renal function, should be closely monitored, as the potassium sparing effect in combination with potassium infusion may result in hyperkalaemia.

Ciclosporin:

Concurrent use of ciclosporin may increase the risk of hyperkalaemia.

Glucose Infusion:

Concomitant use of glucose infusions in hypokalaemic patients may cause a further decrease in plasma potassium concentrations.

4.6 Pregnancy And Lactation

Sterile Potassium Chloride Concentrate 20%, may be used during pregnancy and lactation under the supervision of the prescribing physician.

4.7 Effects On Ability To Drive And Use Machines

Not known.

4.8 Undesirable Effects

Pain at the injection site and phlebitis may occur during IV administration of solutions containing 30 MMOL potassium or more per litre.

Hyperkalaemia is the most common and serious hazard of potassium therapy.

4.9 Overdose

Clinical signs and symptoms of potassium overdosage include: Paraesthesia of the extremities, listlessness, mental confusion, weakness or heaviness of the legs, flaccid paralysis, cold skin, grey pallor, peripheral vascular collapse, fall in blood pressure, cardiac arrhythmias and heart block. Extremely high plasma potassium concentrations (8-11 MMOL/litre) may cause death from cardiac depression, arrhythmias or arrest.

Cardiac arrhythmias or a serum concentration above 6.5 MMOL/litre, require immediate attention and may be treated by intravenous injection over 1-5 minutes of 10 – 20 ml of 10% Calcium Gluconate Injection B.P. with E.C.G. monitoring. Serum concentrations may be reduced by infusion of 300 – 500 mls per hour of 10%-25% glucose solutions containing up to 10 units of insulin for each 20 g of glucose, or by the infusion of sodium bicarbonate solution.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Potassium is the major cation of intracellular fluid and is essential for maintenance of acid-base balance, isotonicity and the electrodynamic characteristics of the cell. Potassium chloride is used as a source of the potassium cation for treatment or prevention of potassium depletion in patients in whom dietary measures are inadequate. Potassium chloride may also be used cautiously to abolish arrhythmias or cardiac glycoside toxicity precipitated by a loss of potassium.

5.2 Pharmacokinetic Properties

Potassium chloride is generally readily absorbed from the gastro-intestinal tract. Potassium is excreted mainly by the kidneys; it is secreted in the distal tubules which are also the site of sodium-potassium exchange. The capacity of the kidneys to conserve potassium is poor and urinary excretion of potassium continues even when there is severe depletion. Tubular secretion of potassium is influenced by several factors, including chloride ion concentration, hydrogen ion exchange, acid-base equilibrium and adrenal hormones. Some potassium is excreted in the faeces and small amounts may also be excreted in saliva, sweat, bile and pancreatic juice.

5.3 Preclinical Safety Data

No further information other than that which is included in the Summary of Product Characteristics.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Water for Injections Ph. Eur.

6.2 Incompatibilities

The compatibility of the large volume IV fluid intended for dilution should be checked before use.

6.3 Shelf Life

36 Months.

6.4 Special Precautions For Storage

Protect from light and store at less than 25°C.

6.5 Nature And Contents Of Container

5 and 10ml clear glass ampoules, hermetically sealed under flame at the gauging point. The ampoules are packed in cartons to contain 10 ampoules.

6.6 Special Precautions For Disposal And Other Handling

Use as directed by a physician.

ADMINISTRATIVE DATA 7. Marketing Authorisation Holder

hameln pharmaceuticals ltd

Gloucester

UK

8. Marketing Authorisation Number(S)

PL 01502/0015R

9. Date Of First Authorisation/Renewal Of The Authorisation

30th August 2001

10. Date Of Revision Of The Text

30/12/2008

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ADHD (Attention Deficit Hyperactivity Disorder) Medications

Definition of ADHD: An inability to control behaviour due to difficulty in processing neural stimuli. More...

Drugs associated with ADHD

The following drugs and medications are in some way related to, or used in the treatment of ADHD. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

See sub-topics

Topics under ADHD Oppositional Defiant Disorder (1 drug) Learn more about ADHD (Attention Deficit Hyperactivity Disorder)

Medical Encyclopedia:

Attention deficit hyperactivity disorder (ADHD)

Drugs.com Health Center:

Mental Health Disorders
Drug List: 5-Htp Adderall Adderall-Xr-Extended-Release-Capsules Aminomine Animi-3 Animi-3-With-Vitamin-D Concerta Cylert Daytrana Desoxyn Desoxyn-Gradumet Dexedrine Dextrostat Divista Eldepryl Epa-Fish-Oil Fish_Oil Fish-Oil-Ultra Focalin Focalin-Xr-Extended-Release-Capsules Icar-Prenatal-Essential-Omega-3 Intuniv Kapvay Liquadd-Solution Lovaza Marine-Lipid-Concentrate Maxepa Maxitears-Dry-Eye-Formula Maxivision-Omega-3-Formula Metadate-Cd-Controlled-Release-Capsules Metadate-Er Methylin Methylin-Er-Controlled-Release-Tablets Mi-Omega Mi-Omega-Nf Norpramin Omacor Omega-500 Pristiq Procentra-Solution Proepa Ritalin Ritalin-La-Extended-Release-Capsules Ritalin-Sr-Controlled-Release-Tablets Sea-Omega Sea-Omega-30 Sea-Omega-70 Strattera Theratears-Nutrition Theromega Tofranil Tofranil-Pm Vyvanse Zelapar

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Isosorbide

In the US, Isosorbide (isosorbide mononitrate systemic) is a member of the drug class miscellaneous uncategorized agents.

US matches:

Isosorbide Isosorbide Dinitrate Isosorbide Dinitrate Extended-Release Isosorbide Dinitrate/Hydralazine Isosorbide Mononitrate Isosorbide Mononitrate Sustained-Release Tablets Isosorbide dinitrate Oral, Sublingual Isosorbide Mononitrate Extended Release Isosorbide Dinitrate/Hydralazine Hydrochloride

UK matches:

Isosorbide Dinitrate Tablets 10mg, 20mgIsosorbide Mononitrate Tablets 10mg, 20mg, 40mg (Actavis UK Ltd)Isosorbide Dinitrate Injection Concentrate BP 1mg/ml (SPC)Isosorbide Dinitrate Tablets BP 10mg (SPC)Isosorbide Dinitrate Tablets BP 20mg (SPC)Isosorbide mononitrate 20mg tablets (SPC)Isosorbide Mononitrate 40mg (SPC)Isosorbide Mononitrate Tablets 40mg (SPC)Ingredient matches for Isosorbide Isosorbide

Isosorbide (BAN, JAN, USAN) is known as Isosorbide in the US.

Isosorbide Mononitrate

Isosorbide Mononitrate is reported as an ingredient of Isosorbide in the following countries:

Bosnia & Herzegowina Cyprus

International Drug Name Search

Glossary

BANBritish Approved NameJANJapanese Accepted NameSPC Summary of Product Characteristics (UK)USANUnited States Adopted Name
Click for further information on drug naming conventions and International Nonproprietary Names.

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Asthma, Maintenance Medications

Drugs associated with Asthma, Maintenance

The following drugs and medications are in some way related to, or used in the treatment of Asthma, Maintenance. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Learn more about Asthma, Maintenance

Medical Encyclopedia:

Asthma Asthma - children Asthma and allergy - resources Occupational asthma
Drug List: A-Methapred-Solution Accolate Accuneb-Solution Advair Advair-Hfa-Inhaler Airet-Solution Alupent Alvesco Asmanex Brethaire Brethine Bricanyl Choledyl Choledyl-Sa Depo-Medrol-Suspension Dulera Elixophyllin-Elixir Flovent Flovent-Diskus-Powder Flovent-Hfa-Aerosol-Inhaler Flovent-Rotadisk-Powder Foradil Intal-Aerosol-Solution Intal-Inhaler-Inhalation Maxair Maxair-Autohaler Medrol Medrol-Dosepak Metaprel Methylprednisolone-Dose-Pack Perforomist Proair-Hfa-Aerosol Proventil Proventil-Hfa-Aerosol Pulmicort-Flexhaler-Powder Pulmicort-Nebuamp Pulmicort-Respules-Suspension Pulmicort Quibron-T Quibron-T-Sr Qvar-Aerosol-Solution Serevent Singulair Solu-Medrol-Solution Symbicort Theo-24-Sustained-Release-Capsules Theo-Dur Theo-Time Theocap-Sustained-Release-Capsules Theochron-Sustained-Release-Tablets Theolair-Tablets Tilade-Aerosol Tornalate Truxophyllin Uniphyl-Sustained-Release-Tablets Ventolin Ventolin-Hfa-Aerosol Volmax Vospire-Er-Extended-Release-Tablets Xolair Xopenex Xopenex-Concentrate Xopenex-Hfa-Aerosol Zyflo Zyflo-Cr-Extended-Release-Tablets

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Anxiety Medications

Definition of Anxiety:

The unpleasant emotional state consisting of psychophysiological responses to anticipation of unreal or imagined danger, ostensibly resulting from unrecognised intrapsychic conflict.

Physiological concomitants include increased heart rate, altered respiration rate, sweating, trembling, weakness and fatigue, psychological concomitants include feelings of impending danger, powerlessness, apprehension and tension.

Drugs associated with Anxiety

The following drugs and medications are in some way related to, or used in the treatment of Anxiety. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

See sub-topics

Topics under Anxiety Anxiety and Stress (10 drugs) Generalized Anxiety Disorder (8 drugs) Obsessive Compulsive Disorder (26 drugs in 2 topics) Panic Disorder (26 drugs) Performance Anxiety (1 drug) Post Traumatic Stress Disorder (10 drugs) Social Anxiety Disorder (7 drugs) Learn more about Anxiety

Medical Encyclopedia:

Generalized anxiety disorder Separation anxiety Stress and anxiety Stress versus anxiety

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Anxiety Mental Health Disorders
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Asthma, acute Medications

Drugs associated with Asthma, acute

The following drugs and medications are in some way related to, or used in the treatment of Asthma, acute. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

Learn more about Asthma, acute

Medical Encyclopedia:

Asthma Asthma - children Asthma and allergy - resources Occupational asthma
Drug List: A-Hydrocort A-Methapred-Solution Accuneb-Solution Adrenaclick-Auto-Injector Adrenalin Adrenalin-Chloride Airet-Solution Alupent Asthmahaler-Aerosol Baycadron Brethaire Brethine Bricanyl Bubbli-Pred Cortef De-Sone-La-Injection Decadron Depo-Medrol-Suspension Dexacen-4-Injection Dexacort-Phosphate-In-Turbinaire Dexamethasone-Intensol Dexasone-Injection Dexasone-La-Injection Dexpak-Tablets-Dose-Pack Elixophyllin-Elixir Epipen-Auto-Injector Epipen-2-Pak Epipen-Auto-Injector Epipen-Jr-Auto-Injector Epipen-Jr-2-Pak Epipen-Jr-Auto-Injector Flo-Pred Hydeltrasol Hydrocortone Isuprel Isuprel-Mistometer Key-Pred-Sp Maxair Maxair-Autohaler Medihaler-Epi Medihaler-Iso Medrol Medrol-Dosepak Metaprel Methylprednisolone-Dose-Pack Millipred Millipred-Dp Orapred Orapred-Odt Pediapred-Liquid Phyllocontin Pred-Ject-50 Predacort-50 Predalone-50 Predate-50 Prelone-Syrup Primatene-Mist-Aerosol Proair-Hfa-Aerosol Proventil Proventil-Hfa-Aerosol Quibron-T Quibron-T-Sr Solu-Cortef-Solution Solu-Medrol-Solution Solurex-Injection Solurex-La-Injection Theo-24-Sustained-Release-Capsules Theo-Dur Theo-Time Theocap-Sustained-Release-Capsules Theochron-Sustained-Release-Tablets Theolair-Tablets Tornalate Truphylline Truxophyllin Twinject-Auto-Injector Twinject-Auto-Injector Twinject-Auto-Injector-Two-Pack Uniphyl-Sustained-Release-Tablets Ventolin Ventolin-Hfa-Aerosol Veripred-20-Solution Volmax Vospire-Er-Extended-Release-Tablets Xopenex Xopenex-Concentrate Xopenex-Hfa-Aerosol Zema-Pak-10-Day

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Maalox Plus Suspension

Maalox plus

Contents:

500 ml Suspension

Contains the equivalent of Dried Aluminium Hydroxide Gel 220 mg, Magnesium Hydroxide 195 mg and Simeticone 25 mg in each 5 ml.

Also contains: methylparaben, propylparaben, micro-crystalline cellulose, sodium carboxymethylcellulose, methylcellulose, hydroxypropylcellulose, hydrogen peroxide, citric acid, sodium saccharin, sorbitol, natural lemon concentrate, swiss creme flavour and water.

Maalox Plus is an antacid which relieves symptoms by neutralising stomach acid and has an antifoaming agent which aids removal of gas.

MA Holder: sanofi-aventis One Onslow Street Guildford Surrey GU1 4YS UK Manufactured by sanofi-aventis S.p.A. Viale Europa 11 - Origgio (VA) Italy For:

symptomatic relief of dyspepsia (indigestion), heartburn and flatulence (wind).

Do not take if you are allergic to any of the active and other ingredients, you are feeling severely debilitated or suffer from kidney disease or hypophosphataemia.

Ask your Pharmacist or Doctor before taking Maalox Plus if you are taking any other medicines or you are pregnant or breast feeding.

Maalox Plus should not be taken at the same time as other medicines, as Maalox Plus may interfere with the absorption if taken within one hour.

Directions:

adults including elderly persons: take one to two 5 ml spoonfuls 20 minutes to 1 hour after meals and at bedtime or as required.

Children: an appropriate proportion of the adult dose.

Children under 5 years old: not more than one 5ml spoonful three times a day.

If symptoms persist consult your doctor.

Contact your doctor immediately if too much is taken.

SHAKE WELL BEFORE USE.

Side Effects:

constipation or diarrhoea can occur but these effects are not common.

Tell your doctor or pharmacist if you notice any other unwanted effects.

Use by the date given on the label below.

Do not allow this product to freeze.

Remember to keep all medicines safely away from children.

Information revised: January 2007

PL5272/0020

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Myozyme 50 mg powder for concentrate for solution for infusion

Myozyme 50 mg powder for concentrate for solution for infusion

Alglucosidase alfa

Read all of this leaflet carefully before you start using this medicine. Keep this leaflet. You may need to read it again. If you have any further questions, ask your doctor or pharmacist. This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. In this leaflet: 1. What Myozyme is and what it is used for 2. Before you use Myozyme 3. How to use Myozyme 4. Possible side effects 5. How to store Myozyme 6. Further information What Myozyme Is And What It Is Used For

Myozyme is used to treat patients who have a confirmed diagnosis of Pompe disease.

People with Pompe disease have low levels of an enzyme called ?-glucosidase. This enzyme helps the body control levels of glycogen (a type of carbohydrate). Glycogen provides the body with energy, but in Pompe disease the levels can get too high.

Myozyme is an artificial enzyme called alglucosidase alfa – this can replace the natural enzyme which is lacking in Pompe disease.

In patients with late-onset Pompe disease a positive effect was observed over an 18 month period on lung function and walking ability. The evidence on the effect of Myozyme in severely affected patients with late onset Pompe disease is limited.

Before You Use Myozyme Do not use Myozyme

If you are allergic (hypersensitive) to alglucosidase alfa or any of the other ingredients of Myozyme.

Take special care with Myozyme

If you are treated with Myozyme, you may experience a reaction while you are being given the medicine or during the next 2 hours. This is known as an infusion-associated reaction and can sometimes be very severe. If you experience a reaction like this, you should tell your doctor immediately. You may need to be given additional medicines to prevent an allergic reaction (e.g. antihistamines and/or corticosteroids) or antipyretics.

Different groups of patients using Myozyme

The information in this leaflet applies to all patient groups including children, adolescents, adults and the elderly.

Using other medicines

Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Pregnancy and breast-feeding

There is no experience of the use of Myozyme in pregnant women. Myozyme should not be used during pregnancy unless clearly necessary. It is recommended to stop breast-feeding when Myozyme is used. Ask your doctor or pharmacist for advice before taking any medicine.

How To Use Myozyme Instructions for proper use

Myozyme is given through a drip into a vein (by intravenous infusion). It is supplied as a powder which will be mixed with sterile water before it is given.

Myozyme is only used under the supervision of a doctor who is knowledgeable in the treatment of Pompe disease.

The recommended dosage of Myozyme is 20 mg/kg body weight given once every 2 weeks.

If you use more Myozyme than you should

There are no cases of overdose reported.

If you forget to use Myozyme

If you have missed an infusion, please contact your doctor.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Possible Side Effects

Like all medicines, Myozyme can cause side effects, although not everybody gets them.

Side effects were mainly seen while patients were being given the medicine or shortly after (“infusion related effects”). Some of these infusion related side effects became serious. Should you experience any reaction like this, please tell your doctor immediately. You may need to be given additional medicines to prevent an allergic reaction (e.g. antihistamines and/or corticosteroids) or antipyretics.

Hives Rash Paleness Redness of the skin (Facial) flushing Increased or high blood pressure Bluish discolouration of the skin Fever or increased body temperature Chills Cough Increased breathing rate Increased or decreased heart rate Vomiting Agitation Tremor Swelling around the eyes Abnormal breathing sounds Difficulty in breathing (including shortness of breath) Headache Cold extremities (e.g. hands, feet) Tingling Pain or local reaction at the site of the drip Dizziness Irritability Itchy skin Retching Low blood pressure Bronchospasm Low level of oxygen in the blood Swelling of the face, swelling of the throat or severe combined swelling of the face, throat and tongue due to a severe allergic reaction Swelling of the arms and legs Feeling hot Increased sweating Eyes tearing Mottled skin Nausea Restlessness Wheezing Heart stopping Chest discomfort Chest pain (not in the heart) Throat tightness Diarrhoea Fatigue Muscle pain Muscle spasms

Life threatening reactions, including very severe generalised allergic reactions and anaphylactic shock, have been reported in some patients.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

How To Store Myozyme

Keep out of the reach and sight of children

Store in a refrigerator (2°C – 8°C).

Do not use after the expiry date stated on the labelling after the letters ‘EXP’.

It is recommended that Myozyme is used immediately after it has been mixed with sterile water. However it can be kept for up to 24 hours if it is kept cool (2°C – 8°C) and in the dark.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Further Information What Myozyme contains The active substance is alglucosidase alfa 50 mg. One vial contains 50 mg of alglucosidase alfa. After reconstitution, the solution contains 5 mg of alglucosidase alfa/ml and after dilution, the concentration varies from 0.5 mg to 4 mg/ml. The other ingredients are mannitol, sodium phosphate monobasic monohydrate sodium phosphate dibasic heptahydrate polysorbate 80 What Myozyme looks like and contents of the pack

Myozyme, 50 mg, is presented as a powder for concentrate for solution for infusion (in a vial- pack: sizes of 1, 10 or 25). Not all pack sizes may be marketed.

Myozyme is supplied as a white to off-white powder. After reconstitution it is a clear, colourless to pale yellow solution, which may contain particles. The reconstituted solution must be further diluted.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder

Genzyme Europe B.V. Gooimeer 10 1411 DD Naarden The Netherlands

Manufacturer

Genzyme Ltd. 37 Hollands Road Haverhill Suffolk CB9 8PU United Kingdom Genzyme Ireland Ltd. IDA Industrial Park Old Kilmeaden Road Waterford Ireland

For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder:

United Kingdom/Ireland Genzyme Therapeutics Ltd United Kingdom Tel:+44 1865 405200

This leaflet was last approved in 10/2009

Detailed information on this medicine is available on the European Medicines Agency (EMEA) web site :http://www.emea.europa.eu/. There are also links to other websites about rare diseases and treatments.

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Myozyme 50 mg powder for concentrate for solution for infusion

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